GALS_SALTY
ID GALS_SALTY Reviewed; 340 AA.
AC P41030;
DT 01-FEB-1995, integrated into UniProtKB/Swiss-Prot.
DT 13-DEC-2001, sequence version 2.
DT 03-AUG-2022, entry version 128.
DE RecName: Full=HTH-type transcriptional regulator GalS;
DE AltName: Full=Mgl repressor and galactose ultrainduction factor;
GN Name=galS; OrderedLocusNames=STM2191;
OS Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720).
OC Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC Enterobacteriaceae; Salmonella.
OX NCBI_TaxID=99287;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=LT2 / SGSC1412 / ATCC 700720;
RX PubMed=11677609; DOI=10.1038/35101614;
RA McClelland M., Sanderson K.E., Spieth J., Clifton S.W., Latreille P.,
RA Courtney L., Porwollik S., Ali J., Dante M., Du F., Hou S., Layman D.,
RA Leonard S., Nguyen C., Scott K., Holmes A., Grewal N., Mulvaney E.,
RA Ryan E., Sun H., Florea L., Miller W., Stoneking T., Nhan M., Waterston R.,
RA Wilson R.K.;
RT "Complete genome sequence of Salmonella enterica serovar Typhimurium LT2.";
RL Nature 413:852-856(2001).
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 323-340.
RC STRAIN=LT2;
RX PubMed=3146019; DOI=10.1007/bf00330498;
RA Benner-Luger D., Boos W.;
RT "The mglB sequence of Salmonella typhimurium LT2; promoter analysis by gene
RT fusions and evidence for a divergently oriented gene coding for the mgl
RT repressor.";
RL Mol. Gen. Genet. 214:579-587(1988).
CC -!- FUNCTION: Repressor of the mgl operon. Binds galactose and D-fucose as
CC inducers. GalS binds to an operator DNA sequence within its own coding
CC sequence (By similarity). {ECO:0000250}.
CC -!- SUBUNIT: Homodimer. {ECO:0000250}.
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DR EMBL; AE006468; AAL21095.1; -; Genomic_DNA.
DR RefSeq; NP_461136.1; NC_003197.2.
DR RefSeq; WP_000628631.1; NC_003197.2.
DR AlphaFoldDB; P41030; -.
DR SMR; P41030; -.
DR STRING; 99287.STM2191; -.
DR PaxDb; P41030; -.
DR EnsemblBacteria; AAL21095; AAL21095; STM2191.
DR GeneID; 1253713; -.
DR KEGG; stm:STM2191; -.
DR PATRIC; fig|99287.12.peg.2318; -.
DR HOGENOM; CLU_037628_6_1_6; -.
DR OMA; RFFAEPY; -.
DR PhylomeDB; P41030; -.
DR BioCyc; SENT99287:STM2191-MON; -.
DR Proteomes; UP000001014; Chromosome.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; IBA:GO_Central.
DR GO; GO:0000976; F:transcription cis-regulatory region binding; IBA:GO_Central.
DR GO; GO:0006355; P:regulation of transcription, DNA-templated; IBA:GO_Central.
DR CDD; cd01392; HTH_LacI; 1.
DR Gene3D; 1.10.260.40; -; 1.
DR InterPro; IPR000843; HTH_LacI.
DR InterPro; IPR046335; LacI/GalR-like_sensor.
DR InterPro; IPR010982; Lambda_DNA-bd_dom_sf.
DR InterPro; IPR028082; Peripla_BP_I.
DR Pfam; PF00356; LacI; 1.
DR Pfam; PF13377; Peripla_BP_3; 1.
DR PRINTS; PR00036; HTHLACI.
DR SMART; SM00354; HTH_LACI; 1.
DR SUPFAM; SSF47413; SSF47413; 1.
DR SUPFAM; SSF53822; SSF53822; 1.
DR PROSITE; PS00356; HTH_LACI_1; 1.
DR PROSITE; PS50932; HTH_LACI_2; 1.
PE 3: Inferred from homology;
KW DNA-binding; Reference proteome; Repressor; Transcription;
KW Transcription regulation.
FT CHAIN 1..340
FT /note="HTH-type transcriptional regulator GalS"
FT /id="PRO_0000107957"
FT DOMAIN 1..56
FT /note="HTH lacI-type"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00111"
FT DNA_BIND 4..23
FT /note="H-T-H motif"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00111"
SQ SEQUENCE 340 AA; 36963 MW; 61B823CC546CE59F CRC64;
MITIRDVARQ AGVSVATVSR VLNNSALVSP DTRDAVMQAV TLLGYRPNAN AQALATQVSD
TIGVVVMDVS DAFFGALVKA VDLVAQQHQK YVLIGNSYHE AEKERHAIEV LIRQRCNALI
VHSKALTDRE LSDFMDQIPG MVLINRIVPG YAHRCVCLDN VSGARMATRM LLNNGHQRIG
YLASSHRIED DAMRREGWLH ALQEQGIAAS ESWIGTGTPD MQGGESAMVE LLGRNLQLTA
VFAYNDNMAA GALTALKDNG IAIPLHLSVI GFDDIPIARY TDPQLTTVRY PIASMAKIAT
ELALQGAAGT LDITATHCFM PTLVRRHSVA WRQNAVLITN
