ID   GALT1_STRPN             Reviewed;         491 AA.
AC   Q97P15;
DT   26-JUL-2002, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-2001, sequence version 1.
DT   03-AUG-2022, entry version 108.
DE   RecName: Full=Galactose-1-phosphate uridylyltransferase 1;
DE            Short=Gal-1-P uridylyltransferase 1;
DE            EC=2.7.7.12;
DE   AltName: Full=UDP-glucose--hexose-1-phosphate uridylyltransferase 1;
GN   Name=galT1; OrderedLocusNames=SP_1829;
OS   Streptococcus pneumoniae serotype 4 (strain ATCC BAA-334 / TIGR4).
OC   Bacteria; Firmicutes; Bacilli; Lactobacillales; Streptococcaceae;
OC   Streptococcus.
OX   NCBI_TaxID=170187;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC BAA-334 / TIGR4;
RX   PubMed=11463916; DOI=10.1126/science.1061217;
RA   Tettelin H., Nelson K.E., Paulsen I.T., Eisen J.A., Read T.D.,
RA   Peterson S.N., Heidelberg J.F., DeBoy R.T., Haft D.H., Dodson R.J.,
RA   Durkin A.S., Gwinn M.L., Kolonay J.F., Nelson W.C., Peterson J.D.,
RA   Umayam L.A., White O., Salzberg S.L., Lewis M.R., Radune D.,
RA   Holtzapple E.K., Khouri H.M., Wolf A.M., Utterback T.R., Hansen C.L.,
RA   McDonald L.A., Feldblyum T.V., Angiuoli S.V., Dickinson T., Hickey E.K.,
RA   Holt I.E., Loftus B.J., Yang F., Smith H.O., Venter J.C., Dougherty B.A.,
RA   Morrison D.A., Hollingshead S.K., Fraser C.M.;
RT   "Complete genome sequence of a virulent isolate of Streptococcus
RT   pneumoniae.";
RL   Science 293:498-506(2001).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=alpha-D-galactose 1-phosphate + UDP-alpha-D-glucose = alpha-D-
CC         glucose 1-phosphate + UDP-alpha-D-galactose; Xref=Rhea:RHEA:13989,
CC         ChEBI:CHEBI:58336, ChEBI:CHEBI:58601, ChEBI:CHEBI:58885,
CC         ChEBI:CHEBI:66914; EC=2.7.7.12;
CC   -!- PATHWAY: Carbohydrate metabolism; galactose metabolism.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the galactose-1-phosphate uridylyltransferase
CC       type 2 family. {ECO:0000305}.
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DR   EMBL; AE005672; AAK75902.1; -; Genomic_DNA.
DR   PIR; E95213; E95213.
DR   RefSeq; WP_000848795.1; NZ_AKVY01000001.1.
DR   AlphaFoldDB; Q97P15; -.
DR   STRING; 170187.SP_1829; -.
DR   EnsemblBacteria; AAK75902; AAK75902; SP_1829.
DR   KEGG; spn:SP_1829; -.
DR   eggNOG; COG4468; Bacteria.
DR   OMA; YEKHVPM; -.
DR   PhylomeDB; Q97P15; -.
DR   BioCyc; SPNE170187:G1FZB-1859-MON; -.
DR   UniPathway; UPA00214; -.
DR   Proteomes; UP000000585; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0008108; F:UDP-glucose:hexose-1-phosphate uridylyltransferase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0006012; P:galactose metabolic process; IEA:UniProtKB-UniRule.
DR   HAMAP; MF_00571; GalP_UDP_trans; 1.
DR   InterPro; IPR000766; GalP_uridyl_Trfase_II.
DR   InterPro; IPR023425; GalP_uridyl_Trfase_II_CS.
DR   InterPro; IPR005850; GalP_Utransf_C.
DR   InterPro; IPR005849; GalP_Utransf_N.
DR   PANTHER; PTHR39191; PTHR39191; 1.
DR   Pfam; PF02744; GalP_UDP_tr_C; 1.
DR   Pfam; PF01087; GalP_UDP_transf; 1.
DR   PIRSF; PIRSF006005; GalT_BS; 1.
DR   TIGRFAMs; TIGR01239; galT_2; 1.
DR   PROSITE; PS01163; GAL_P_UDP_TRANSF_II; 1.
PE   3: Inferred from homology;
KW   Carbohydrate metabolism; Cytoplasm; Galactose metabolism;
KW   Nucleotidyltransferase; Transferase.
FT   CHAIN           1..491
FT                   /note="Galactose-1-phosphate uridylyltransferase 1"
FT                   /id="PRO_0000169914"
SQ   SEQUENCE   491 AA;  56381 MW;  A11F78D61F4D4B09 CRC64;
     MKTIIDNFVD RVIEYGMYNE IDKIYVKNRV LALIGEEGID RISDENDLKQ IKDYLVEIAL
     KNGKIKDLIE EKECLGAELM NFIVPLPSRL NDIFWSSYDI SPQEAVEEFY KLSKDSDYIK
     TSAIAKNIEF RASTKYGELE ITINLSKPEK DPKTIAAEKL VKATNYPKCL LCMENEGYQG
     RINYPARSNH RIIRLKLGDE VWGFQYSPYS YFNEHAIFLN SQHVPMAITS KTFEQLLEIV
     DILPGYFAGS NSDLPISGGS ILSHNHYQGG KHIFPMEKAK FESEFCFKDF EDVNAGIVKW
     PMSVIRLQSE NKNRLLDLAT KILNKWREYS DLEVDIIAMT EDVPHHTVTP IARKVDGRYE
     LDIVLRDNHT TEQYPDGVFH PHQDVQHIKK ENIGLIEVMG LAILPPRLKP ELEEVGKYLL
     GEDNAIADYH LEWADQLKEK YPRINKEEVN SVVQHEAGQV FARVLEDAGV YKNTPSGHEA
     FMRFVKSVGI N