ID   GALT1_STRR6             Reviewed;         491 AA.
AC   Q8DNL8;
DT   30-APR-2003, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2003, sequence version 1.
DT   25-MAY-2022, entry version 98.
DE   RecName: Full=Galactose-1-phosphate uridylyltransferase 1;
DE            Short=Gal-1-P uridylyltransferase 1;
DE            EC=2.7.7.12;
DE   AltName: Full=UDP-glucose--hexose-1-phosphate uridylyltransferase 1;
GN   Name=galT1; OrderedLocusNames=spr1648;
OS   Streptococcus pneumoniae (strain ATCC BAA-255 / R6).
OC   Bacteria; Firmicutes; Bacilli; Lactobacillales; Streptococcaceae;
OC   Streptococcus.
OX   NCBI_TaxID=171101;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC BAA-255 / R6;
RX   PubMed=11544234; DOI=10.1128/jb.183.19.5709-5717.2001;
RA   Hoskins J., Alborn W.E. Jr., Arnold J., Blaszczak L.C., Burgett S.,
RA   DeHoff B.S., Estrem S.T., Fritz L., Fu D.-J., Fuller W., Geringer C.,
RA   Gilmour R., Glass J.S., Khoja H., Kraft A.R., Lagace R.E., LeBlanc D.J.,
RA   Lee L.N., Lefkowitz E.J., Lu J., Matsushima P., McAhren S.M., McHenney M.,
RA   McLeaster K., Mundy C.W., Nicas T.I., Norris F.H., O'Gara M., Peery R.B.,
RA   Robertson G.T., Rockey P., Sun P.-M., Winkler M.E., Yang Y.,
RA   Young-Bellido M., Zhao G., Zook C.A., Baltz R.H., Jaskunas S.R.,
RA   Rosteck P.R. Jr., Skatrud P.L., Glass J.I.;
RT   "Genome of the bacterium Streptococcus pneumoniae strain R6.";
RL   J. Bacteriol. 183:5709-5717(2001).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=alpha-D-galactose 1-phosphate + UDP-alpha-D-glucose = alpha-D-
CC         glucose 1-phosphate + UDP-alpha-D-galactose; Xref=Rhea:RHEA:13989,
CC         ChEBI:CHEBI:58336, ChEBI:CHEBI:58601, ChEBI:CHEBI:58885,
CC         ChEBI:CHEBI:66914; EC=2.7.7.12;
CC   -!- PATHWAY: Carbohydrate metabolism; galactose metabolism.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the galactose-1-phosphate uridylyltransferase
CC       type 2 family. {ECO:0000305}.
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DR   EMBL; AE007317; AAL00451.1; -; Genomic_DNA.
DR   PIR; F98077; F98077.
DR   RefSeq; NP_359240.1; NC_003098.1.
DR   RefSeq; WP_000848802.1; NC_003098.1.
DR   AlphaFoldDB; Q8DNL8; -.
DR   STRING; 171101.spr1648; -.
DR   EnsemblBacteria; AAL00451; AAL00451; spr1648.
DR   GeneID; 60233824; -.
DR   KEGG; spr:spr1648; -.
DR   PATRIC; fig|171101.6.peg.1777; -.
DR   eggNOG; COG4468; Bacteria.
DR   HOGENOM; CLU_047799_0_0_9; -.
DR   OMA; YEKHVPM; -.
DR   UniPathway; UPA00214; -.
DR   Proteomes; UP000000586; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0008108; F:UDP-glucose:hexose-1-phosphate uridylyltransferase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0006012; P:galactose metabolic process; IEA:UniProtKB-UniRule.
DR   HAMAP; MF_00571; GalP_UDP_trans; 1.
DR   InterPro; IPR000766; GalP_uridyl_Trfase_II.
DR   InterPro; IPR023425; GalP_uridyl_Trfase_II_CS.
DR   InterPro; IPR005850; GalP_Utransf_C.
DR   InterPro; IPR005849; GalP_Utransf_N.
DR   PANTHER; PTHR39191; PTHR39191; 1.
DR   Pfam; PF02744; GalP_UDP_tr_C; 1.
DR   Pfam; PF01087; GalP_UDP_transf; 1.
DR   PIRSF; PIRSF006005; GalT_BS; 1.
DR   TIGRFAMs; TIGR01239; galT_2; 1.
DR   PROSITE; PS01163; GAL_P_UDP_TRANSF_II; 1.
PE   3: Inferred from homology;
KW   Carbohydrate metabolism; Cytoplasm; Galactose metabolism;
KW   Nucleotidyltransferase; Reference proteome; Transferase.
FT   CHAIN           1..491
FT                   /note="Galactose-1-phosphate uridylyltransferase 1"
FT                   /id="PRO_0000169916"
SQ   SEQUENCE   491 AA;  56448 MW;  A67A027CDA34F56A CRC64;
     MKTIIDNFVD RVIEYGMYNE IDKIYVKNRV LALIGEEGTD RISDENDLKQ IKDYLVEIAL
     KNGKIKDLIE EKECLGAELM NFIVPLPSRL NDIFWSSYDI SPQEAVEEFY KLSKDSDYIK
     TSAIAKNIEF RASTKYGELE ITINLSKPEK DPKTIAAEKL VKATNYPKCL LCMENEGYQG
     RINYPARSNH RIIRLKLGDE VWGFQYSPYL YFNEHAIFLN SQHVPMAITS KTFEQLLEIV
     DILPGYFAGS NSDLPISGGS ILSHNHYQGG KHIFPMEKAK FESEFRFKDF EDVNAGIVKW
     PMSVIRLQSE NKNRLLDLAT KILNKWREYS DLEVDIIAMT EDVPHHTVTP IARKVDGRYE
     LDIVLRDNHT TEQYPDGVFH PHQDVQHIKK ENIGLIEVMG LAILPPRLKP ELEEVGKYLL
     GEDNAIADYH LEWADQLKEK YPRINKEEVN SVVQHEAGQV FARVLEDAGV YKNTPSGHEA
     FMRFVKSVGI N