ID   GALT2_STRPN             Reviewed;         493 AA.
AC   Q97NZ7;
DT   26-JUL-2002, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-2001, sequence version 1.
DT   03-AUG-2022, entry version 110.
DE   RecName: Full=Galactose-1-phosphate uridylyltransferase 2;
DE            Short=Gal-1-P uridylyltransferase 2;
DE            EC=2.7.7.12;
DE   AltName: Full=UDP-glucose--hexose-1-phosphate uridylyltransferase 2;
GN   Name=galT2; OrderedLocusNames=SP_1852;
OS   Streptococcus pneumoniae serotype 4 (strain ATCC BAA-334 / TIGR4).
OC   Bacteria; Firmicutes; Bacilli; Lactobacillales; Streptococcaceae;
OC   Streptococcus.
OX   NCBI_TaxID=170187;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC BAA-334 / TIGR4;
RX   PubMed=11463916; DOI=10.1126/science.1061217;
RA   Tettelin H., Nelson K.E., Paulsen I.T., Eisen J.A., Read T.D.,
RA   Peterson S.N., Heidelberg J.F., DeBoy R.T., Haft D.H., Dodson R.J.,
RA   Durkin A.S., Gwinn M.L., Kolonay J.F., Nelson W.C., Peterson J.D.,
RA   Umayam L.A., White O., Salzberg S.L., Lewis M.R., Radune D.,
RA   Holtzapple E.K., Khouri H.M., Wolf A.M., Utterback T.R., Hansen C.L.,
RA   McDonald L.A., Feldblyum T.V., Angiuoli S.V., Dickinson T., Hickey E.K.,
RA   Holt I.E., Loftus B.J., Yang F., Smith H.O., Venter J.C., Dougherty B.A.,
RA   Morrison D.A., Hollingshead S.K., Fraser C.M.;
RT   "Complete genome sequence of a virulent isolate of Streptococcus
RT   pneumoniae.";
RL   Science 293:498-506(2001).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=alpha-D-galactose 1-phosphate + UDP-alpha-D-glucose = alpha-D-
CC         glucose 1-phosphate + UDP-alpha-D-galactose; Xref=Rhea:RHEA:13989,
CC         ChEBI:CHEBI:58336, ChEBI:CHEBI:58601, ChEBI:CHEBI:58885,
CC         ChEBI:CHEBI:66914; EC=2.7.7.12;
CC   -!- PATHWAY: Carbohydrate metabolism; galactose metabolism.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the galactose-1-phosphate uridylyltransferase
CC       type 2 family. {ECO:0000305}.
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DR   EMBL; AE005672; AAK75924.1; -; Genomic_DNA.
DR   PIR; C95216; C95216.
DR   RefSeq; WP_000177062.1; NZ_AKVY01000001.1.
DR   AlphaFoldDB; Q97NZ7; -.
DR   STRING; 170187.SP_1852; -.
DR   EnsemblBacteria; AAK75924; AAK75924; SP_1852.
DR   KEGG; spn:SP_1852; -.
DR   eggNOG; COG4468; Bacteria.
DR   OMA; IVDWPMS; -.
DR   PhylomeDB; Q97NZ7; -.
DR   BioCyc; SPNE170187:G1FZB-1882-MON; -.
DR   UniPathway; UPA00214; -.
DR   Proteomes; UP000000585; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0008108; F:UDP-glucose:hexose-1-phosphate uridylyltransferase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0006012; P:galactose metabolic process; IEA:UniProtKB-UniRule.
DR   HAMAP; MF_00571; GalP_UDP_trans; 1.
DR   InterPro; IPR000766; GalP_uridyl_Trfase_II.
DR   InterPro; IPR023425; GalP_uridyl_Trfase_II_CS.
DR   InterPro; IPR005850; GalP_Utransf_C.
DR   InterPro; IPR005849; GalP_Utransf_N.
DR   PANTHER; PTHR39191; PTHR39191; 1.
DR   Pfam; PF02744; GalP_UDP_tr_C; 1.
DR   Pfam; PF01087; GalP_UDP_transf; 1.
DR   PIRSF; PIRSF006005; GalT_BS; 1.
DR   TIGRFAMs; TIGR01239; galT_2; 1.
DR   PROSITE; PS01163; GAL_P_UDP_TRANSF_II; 1.
PE   3: Inferred from homology;
KW   Carbohydrate metabolism; Cytoplasm; Galactose metabolism;
KW   Nucleotidyltransferase; Transferase.
FT   CHAIN           1..493
FT                   /note="Galactose-1-phosphate uridylyltransferase 2"
FT                   /id="PRO_0000169915"
SQ   SEQUENCE   493 AA;  56148 MW;  6EB5349B3BD7BA8A CRC64;
     MTLVNKFVTH VISESSFEEM DRIYLTNRVL ARVGEGVLEV ETNLDKLIDL KDQLVEEAVR
     LETIEDSQTA REILGAELMD LVTPCPSQVN RDFWATYAHS PEQAIEDFYQ LSQKNDYIKL
     KAIARNIAYR VPSDYGELEI TINLSKPEKD PKEIVAAKLV QASNYPQCQL CLENEGYHGR
     VNHPARSNHR IIRFEMVGQE WGFQYSPYAY FNEHCIFLDG QHRPMAISRQ SFERLLAIVD
     QFPGYFAGSN ADLPIVGGSI LTHDHYQGGR HVFPMELAPL QKAFRFAGFE QVKAGIVKWP
     MSVLRLTSDS KEDLINLADK ILQEWRQYSD PAVQILAETD RTPHHTITPI ARKRDGQFEL
     DLVLRDNQTS AEYPDGIYHP HKDVQHIKKE NIGLIEVMGL AILPPRLKEE VEQVASYLVG
     EAVTVADYHQ EWADQLKSQH PDLTDKEKAL AIVKDSVGAI FARVLEDAGV YKQTEQGQTA
     FMRFVEQVGI LLD