ID   GALT2_STRR6             Reviewed;         493 AA.
AC   Q8DNK8;
DT   30-APR-2003, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2003, sequence version 1.
DT   25-MAY-2022, entry version 97.
DE   RecName: Full=Galactose-1-phosphate uridylyltransferase 2;
DE            Short=Gal-1-P uridylyltransferase 2;
DE            EC=2.7.7.12;
DE   AltName: Full=UDP-glucose--hexose-1-phosphate uridylyltransferase 2;
GN   Name=galT2; OrderedLocusNames=spr1667;
OS   Streptococcus pneumoniae (strain ATCC BAA-255 / R6).
OC   Bacteria; Firmicutes; Bacilli; Lactobacillales; Streptococcaceae;
OC   Streptococcus.
OX   NCBI_TaxID=171101;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC BAA-255 / R6;
RX   PubMed=11544234; DOI=10.1128/jb.183.19.5709-5717.2001;
RA   Hoskins J., Alborn W.E. Jr., Arnold J., Blaszczak L.C., Burgett S.,
RA   DeHoff B.S., Estrem S.T., Fritz L., Fu D.-J., Fuller W., Geringer C.,
RA   Gilmour R., Glass J.S., Khoja H., Kraft A.R., Lagace R.E., LeBlanc D.J.,
RA   Lee L.N., Lefkowitz E.J., Lu J., Matsushima P., McAhren S.M., McHenney M.,
RA   McLeaster K., Mundy C.W., Nicas T.I., Norris F.H., O'Gara M., Peery R.B.,
RA   Robertson G.T., Rockey P., Sun P.-M., Winkler M.E., Yang Y.,
RA   Young-Bellido M., Zhao G., Zook C.A., Baltz R.H., Jaskunas S.R.,
RA   Rosteck P.R. Jr., Skatrud P.L., Glass J.I.;
RT   "Genome of the bacterium Streptococcus pneumoniae strain R6.";
RL   J. Bacteriol. 183:5709-5717(2001).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=alpha-D-galactose 1-phosphate + UDP-alpha-D-glucose = alpha-D-
CC         glucose 1-phosphate + UDP-alpha-D-galactose; Xref=Rhea:RHEA:13989,
CC         ChEBI:CHEBI:58336, ChEBI:CHEBI:58601, ChEBI:CHEBI:58885,
CC         ChEBI:CHEBI:66914; EC=2.7.7.12;
CC   -!- PATHWAY: Carbohydrate metabolism; galactose metabolism.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the galactose-1-phosphate uridylyltransferase
CC       type 2 family. {ECO:0000305}.
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DR   EMBL; AE007317; AAL00470.1; -; Genomic_DNA.
DR   PIR; A98080; A98080.
DR   RefSeq; NP_359259.1; NC_003098.1.
DR   RefSeq; WP_000177009.1; NC_003098.1.
DR   AlphaFoldDB; Q8DNK8; -.
DR   STRING; 171101.spr1667; -.
DR   EnsemblBacteria; AAL00470; AAL00470; spr1667.
DR   GeneID; 60233734; -.
DR   KEGG; spr:spr1667; -.
DR   PATRIC; fig|171101.6.peg.1801; -.
DR   eggNOG; COG4468; Bacteria.
DR   HOGENOM; CLU_047799_0_0_9; -.
DR   OMA; IVDWPMS; -.
DR   UniPathway; UPA00214; -.
DR   Proteomes; UP000000586; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0008108; F:UDP-glucose:hexose-1-phosphate uridylyltransferase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0006012; P:galactose metabolic process; IEA:UniProtKB-UniRule.
DR   HAMAP; MF_00571; GalP_UDP_trans; 1.
DR   InterPro; IPR000766; GalP_uridyl_Trfase_II.
DR   InterPro; IPR023425; GalP_uridyl_Trfase_II_CS.
DR   InterPro; IPR005850; GalP_Utransf_C.
DR   InterPro; IPR005849; GalP_Utransf_N.
DR   PANTHER; PTHR39191; PTHR39191; 1.
DR   Pfam; PF02744; GalP_UDP_tr_C; 1.
DR   Pfam; PF01087; GalP_UDP_transf; 1.
DR   PIRSF; PIRSF006005; GalT_BS; 1.
DR   TIGRFAMs; TIGR01239; galT_2; 1.
DR   PROSITE; PS01163; GAL_P_UDP_TRANSF_II; 1.
PE   3: Inferred from homology;
KW   Carbohydrate metabolism; Cytoplasm; Galactose metabolism;
KW   Nucleotidyltransferase; Reference proteome; Transferase.
FT   CHAIN           1..493
FT                   /note="Galactose-1-phosphate uridylyltransferase 2"
FT                   /id="PRO_0000169917"
SQ   SEQUENCE   493 AA;  56252 MW;  D9E074E4536A5938 CRC64;
     MTLVDKFVTH VISESSFEEM DRIYLTNRVL SRVGEGVLEV ETNLDKLIDL KDQLVEETVR
     LETIEDSQTA REILGTELMD LVTPCPSQVN RDFWEAYAYS PEQAIEDFYQ LSQKNDYIKL
     KAIAKNIAYR VPSDYGELEI TINLSKPEKD PKEIAVAKLV QASNYPQCQL CLENEGYHGR
     VNHPARSNHR IIRFEMVGQE WGFQYSPYAY FNEHCIFLDG QHRPMAISRQ SFERLLAIVE
     QFPGYFAGSN ADLPIVGGSI LTHDHYQGGR HVFPMELAPL QKTFRFAGFE QVKAGIIKWP
     MSVLRLTSDS KEDLINLADK IFQEWRQYSD SSVQILAETD GTPHHTITPI ARKRDGQFEL
     DLVLRDNQTS AEHPDGIYHP HKDVQHIKKE NIGLIEVMGL AILPPRLKEE VEQVASYLVG
     EAVTVADYHQ EWADQLKSQH PDLTDKEKAL AIVKDSVGAI FVRVLEDAGV YKQTEQGQTA
     FMRFVEQVGI LLD