ID   GALT_ALKHC              Reviewed;         508 AA.
AC   Q9KDV2; Q9RC74;
DT   01-DEC-2000, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-2000, sequence version 1.
DT   03-AUG-2022, entry version 116.
DE   RecName: Full=Galactose-1-phosphate uridylyltransferase;
DE            Short=Gal-1-P uridylyltransferase;
DE            EC=2.7.7.12;
DE   AltName: Full=UDP-glucose--hexose-1-phosphate uridylyltransferase;
GN   Name=galT; OrderedLocusNames=BH1109;
OS   Alkalihalobacillus halodurans (strain ATCC BAA-125 / DSM 18197 / FERM 7344
OS   / JCM 9153 / C-125) (Bacillus halodurans).
OC   Bacteria; Firmicutes; Bacilli; Bacillales; Bacillaceae; Alkalihalobacillus.
OX   NCBI_TaxID=272558;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC BAA-125 / DSM 18197 / FERM 7344 / JCM 9153 / C-125;
RX   PubMed=11058132; DOI=10.1093/nar/28.21.4317;
RA   Takami H., Nakasone K., Takaki Y., Maeno G., Sasaki R., Masui N., Fuji F.,
RA   Hirama C., Nakamura Y., Ogasawara N., Kuhara S., Horikoshi K.;
RT   "Complete genome sequence of the alkaliphilic bacterium Bacillus halodurans
RT   and genomic sequence comparison with Bacillus subtilis.";
RL   Nucleic Acids Res. 28:4317-4331(2000).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-450.
RC   STRAIN=ATCC BAA-125 / DSM 18197 / FERM 7344 / JCM 9153 / C-125;
RX   PubMed=10484179; DOI=10.1007/s007920050120;
RA   Takami H., Takaki Y., Nakasone K., Sakiyama T., Maeno G., Sasaki R.,
RA   Hirama C., Fuji F., Masui N.;
RT   "Genetic analysis of the chromosome of alkaliphilic Bacillus halodurans C-
RT   125.";
RL   Extremophiles 3:227-233(1999).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=alpha-D-galactose 1-phosphate + UDP-alpha-D-glucose = alpha-D-
CC         glucose 1-phosphate + UDP-alpha-D-galactose; Xref=Rhea:RHEA:13989,
CC         ChEBI:CHEBI:58336, ChEBI:CHEBI:58601, ChEBI:CHEBI:58885,
CC         ChEBI:CHEBI:66914; EC=2.7.7.12;
CC   -!- PATHWAY: Carbohydrate metabolism; galactose metabolism.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the galactose-1-phosphate uridylyltransferase
CC       type 2 family. {ECO:0000305}.
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DR   EMBL; BA000004; BAB04828.1; -; Genomic_DNA.
DR   EMBL; AB024554; BAA83925.1; -; Genomic_DNA.
DR   PIR; E83788; E83788.
DR   RefSeq; WP_010897279.1; NC_002570.2.
DR   AlphaFoldDB; Q9KDV2; -.
DR   STRING; 272558.10173724; -.
DR   EnsemblBacteria; BAB04828; BAB04828; BAB04828.
DR   KEGG; bha:BH1109; -.
DR   eggNOG; COG4468; Bacteria.
DR   HOGENOM; CLU_047799_0_0_9; -.
DR   OMA; YEKHVPM; -.
DR   OrthoDB; 801432at2; -.
DR   UniPathway; UPA00214; -.
DR   Proteomes; UP000001258; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0008108; F:UDP-glucose:hexose-1-phosphate uridylyltransferase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0006012; P:galactose metabolic process; IEA:UniProtKB-UniRule.
DR   HAMAP; MF_00571; GalP_UDP_trans; 1.
DR   InterPro; IPR000766; GalP_uridyl_Trfase_II.
DR   InterPro; IPR023425; GalP_uridyl_Trfase_II_CS.
DR   InterPro; IPR005850; GalP_Utransf_C.
DR   InterPro; IPR005849; GalP_Utransf_N.
DR   PANTHER; PTHR39191; PTHR39191; 1.
DR   Pfam; PF02744; GalP_UDP_tr_C; 1.
DR   Pfam; PF01087; GalP_UDP_transf; 1.
DR   PIRSF; PIRSF006005; GalT_BS; 1.
DR   TIGRFAMs; TIGR01239; galT_2; 1.
DR   PROSITE; PS01163; GAL_P_UDP_TRANSF_II; 1.
PE   3: Inferred from homology;
KW   Carbohydrate metabolism; Cytoplasm; Galactose metabolism;
KW   Nucleotidyltransferase; Reference proteome; Transferase.
FT   CHAIN           1..508
FT                   /note="Galactose-1-phosphate uridylyltransferase"
FT                   /id="PRO_0000169899"
SQ   SEQUENCE   508 AA;  57990 MW;  16AF6F607FCEAE2E CRC64;
     MSQSSIAIQI EALLTYALQH GLITKWDIDA SRNRVLDVLD LDELEPVEQV DVECEMPYPI
     LENILDWAAE NGRLEANTVT YRDLLDTKLM GALLGQPSET IRTFYERYEQ QGPEEATKVF
     YDFSKQVHYI RTDRIAKNEH WFSETPYGQL EITINLSKPE KDPKAIAQAK HLQASSYPKC
     LLCKENVGYR GRVNHPARQN LRVIPVELNQ EQWYMQFSPY VYYNEHAIVF SGEHVPMKIS
     TETFARLLEF TEKFPHYFIG SNADLPIVGG SILSHDHFQG GNHAFPMAKA SMEKTFSISR
     FPSVIAGIVK WPMSVVRLQG MDRSELVKAA DHVYHAWQAY GDEAADIYPF TGDTPHNTIT
     PIARRRGELF ELDLVLRNNR TSKEHPDGIF HPHQEVHHIK KENIGLIEVM GLAVLPGRLK
     EELELLAEAL LSSDPRQVIA RYEQIQKHEA WALAIKERHA HLHDSNVMDI LRDEIGKVFA
     TILAHAGVFK RTGEGAAAFD RFISTLNQ