ID   GALT_BUTFI              Reviewed;         389 AA.
AC   P45981;
DT   01-NOV-1995, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1995, sequence version 1.
DT   25-MAY-2022, entry version 70.
DE   RecName: Full=Galactose-1-phosphate uridylyltransferase;
DE            Short=Gal-1-P uridylyltransferase;
DE            EC=2.7.7.12;
DE   AltName: Full=UDP-glucose--hexose-1-phosphate uridylyltransferase;
DE   Flags: Fragment;
GN   Name=galT;
OS   Butyrivibrio fibrisolvens.
OC   Bacteria; Firmicutes; Clostridia; Eubacteriales; Lachnospiraceae;
OC   Butyrivibrio.
OX   NCBI_TaxID=831;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=1905520; DOI=10.1128/aem.57.4.1227-1234.1991;
RA   Utt E.A., Eddy C.K., Keshav K.F., Ingram L.O.;
RT   "Sequencing and expression of the Butyrivibrio fibrisolvens xylB gene
RT   encoding a novel bifunctional protein with beta-D-xylosidase and alpha-L-
RT   arabinofuranosidase activities.";
RL   Appl. Environ. Microbiol. 57:1227-1234(1991).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=alpha-D-galactose 1-phosphate + UDP-alpha-D-glucose = alpha-D-
CC         glucose 1-phosphate + UDP-alpha-D-galactose; Xref=Rhea:RHEA:13989,
CC         ChEBI:CHEBI:58336, ChEBI:CHEBI:58601, ChEBI:CHEBI:58885,
CC         ChEBI:CHEBI:66914; EC=2.7.7.12;
CC   -!- PATHWAY: Carbohydrate metabolism; galactose metabolism.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the galactose-1-phosphate uridylyltransferase
CC       type 2 family. {ECO:0000305}.
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DR   EMBL; M55537; AAA63611.1; -; Genomic_DNA.
DR   PIR; C49776; C49776.
DR   AlphaFoldDB; P45981; -.
DR   UniPathway; UPA00214; -.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0008108; F:UDP-glucose:hexose-1-phosphate uridylyltransferase activity; IEA:UniProtKB-EC.
DR   GO; GO:0006012; P:galactose metabolic process; IEA:UniProtKB-UniPathway.
DR   HAMAP; MF_00571; GalP_UDP_trans; 1.
DR   InterPro; IPR000766; GalP_uridyl_Trfase_II.
DR   InterPro; IPR023425; GalP_uridyl_Trfase_II_CS.
DR   InterPro; IPR005850; GalP_Utransf_C.
DR   InterPro; IPR005849; GalP_Utransf_N.
DR   PANTHER; PTHR39191; PTHR39191; 1.
DR   Pfam; PF02744; GalP_UDP_tr_C; 1.
DR   Pfam; PF01087; GalP_UDP_transf; 1.
DR   PROSITE; PS01163; GAL_P_UDP_TRANSF_II; 1.
PE   3: Inferred from homology;
KW   Carbohydrate metabolism; Cytoplasm; Galactose metabolism;
KW   Nucleotidyltransferase; Transferase.
FT   CHAIN           1..>389
FT                   /note="Galactose-1-phosphate uridylyltransferase"
FT                   /id="PRO_0000169901"
FT   NON_TER         389
SQ   SEQUENCE   389 AA;  45002 MW;  9CB1B6B7CFA55C22 CRC64;
     MLQESIKKLV QYGIDMGLTP ECERIYTTNL LLECMKEDEY IDPDCDLSNI ILEDVLKELL
     DEAVNRGIIE DSVTHRDLFD TKLMNQLCPR PKQVIDDFNR IYDNHGPIAA TDYFYKLSKA
     SDYIRTYRVK KDLKWTCDTE YGTLDITINL SKPEKDPKAI AAAKNAKQST YPKCQLCMEN
     EGYAGRINHP ARENHRIIPI TINNSNWGFQ YSPYVYYNEH CIVFNGEHTP MKIERATFVK
     LFDFIKLFPH YFLGSNADLP IVGGSILSHD HFQGGHYTFA MEKAPIIQEF TVKGYEDVKA
     GIVKWPLSVI RLQCKDETRL IDLATNILDK WRNYTDEEAY IFAETDGEPH NTITPIARKR
     GDYFELDPLE STCRHASLAL AVVLQRRDW