ID   GALT_CALS4              Reviewed;         519 AA.
AC   Q8R8R6;
DT   26-JUL-2002, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-2002, sequence version 1.
DT   25-MAY-2022, entry version 97.
DE   RecName: Full=Galactose-1-phosphate uridylyltransferase {ECO:0000255|HAMAP-Rule:MF_00571};
DE            Short=Gal-1-P uridylyltransferase {ECO:0000255|HAMAP-Rule:MF_00571};
DE            EC=2.7.7.12 {ECO:0000255|HAMAP-Rule:MF_00571};
DE   AltName: Full=UDP-glucose--hexose-1-phosphate uridylyltransferase {ECO:0000255|HAMAP-Rule:MF_00571};
GN   Name=galT {ECO:0000255|HAMAP-Rule:MF_00571}; OrderedLocusNames=TTE1929;
OS   Caldanaerobacter subterraneus subsp. tengcongensis (strain DSM 15242 / JCM
OS   11007 / NBRC 100824 / MB4) (Thermoanaerobacter tengcongensis).
OC   Bacteria; Firmicutes; Clostridia; Thermoanaerobacterales;
OC   Thermoanaerobacteraceae; Caldanaerobacter.
OX   NCBI_TaxID=273068;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=DSM 15242 / JCM 11007 / NBRC 100824 / MB4;
RX   PubMed=11997336; DOI=10.1101/gr.219302;
RA   Bao Q., Tian Y., Li W., Xu Z., Xuan Z., Hu S., Dong W., Yang J., Chen Y.,
RA   Xue Y., Xu Y., Lai X., Huang L., Dong X., Ma Y., Ling L., Tan H., Chen R.,
RA   Wang J., Yu J., Yang H.;
RT   "A complete sequence of the T. tengcongensis genome.";
RL   Genome Res. 12:689-700(2002).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=alpha-D-galactose 1-phosphate + UDP-alpha-D-glucose = alpha-D-
CC         glucose 1-phosphate + UDP-alpha-D-galactose; Xref=Rhea:RHEA:13989,
CC         ChEBI:CHEBI:58336, ChEBI:CHEBI:58601, ChEBI:CHEBI:58885,
CC         ChEBI:CHEBI:66914; EC=2.7.7.12; Evidence={ECO:0000255|HAMAP-
CC         Rule:MF_00571};
CC   -!- PATHWAY: Carbohydrate metabolism; galactose metabolism.
CC       {ECO:0000255|HAMAP-Rule:MF_00571}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_00571}.
CC   -!- SIMILARITY: Belongs to the galactose-1-phosphate uridylyltransferase
CC       type 2 family. {ECO:0000255|HAMAP-Rule:MF_00571}.
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DR   EMBL; AE008691; AAM25108.1; -; Genomic_DNA.
DR   RefSeq; WP_009609960.1; NC_003869.1.
DR   AlphaFoldDB; Q8R8R6; -.
DR   STRING; 273068.TTE1929; -.
DR   PRIDE; Q8R8R6; -.
DR   EnsemblBacteria; AAM25108; AAM25108; TTE1929.
DR   KEGG; tte:TTE1929; -.
DR   eggNOG; COG4468; Bacteria.
DR   HOGENOM; CLU_047799_0_0_9; -.
DR   OMA; IVDWPMS; -.
DR   OrthoDB; 801432at2; -.
DR   UniPathway; UPA00214; -.
DR   Proteomes; UP000000555; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0008108; F:UDP-glucose:hexose-1-phosphate uridylyltransferase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0006012; P:galactose metabolic process; IEA:UniProtKB-UniRule.
DR   HAMAP; MF_00571; GalP_UDP_trans; 1.
DR   InterPro; IPR000766; GalP_uridyl_Trfase_II.
DR   InterPro; IPR023425; GalP_uridyl_Trfase_II_CS.
DR   InterPro; IPR005850; GalP_Utransf_C.
DR   InterPro; IPR005849; GalP_Utransf_N.
DR   PANTHER; PTHR39191; PTHR39191; 1.
DR   Pfam; PF02744; GalP_UDP_tr_C; 1.
DR   Pfam; PF01087; GalP_UDP_transf; 1.
DR   PIRSF; PIRSF006005; GalT_BS; 1.
DR   TIGRFAMs; TIGR01239; galT_2; 1.
DR   PROSITE; PS01163; GAL_P_UDP_TRANSF_II; 1.
PE   3: Inferred from homology;
KW   Carbohydrate metabolism; Cytoplasm; Galactose metabolism;
KW   Nucleotidyltransferase; Reference proteome; Transferase.
FT   CHAIN           1..519
FT                   /note="Galactose-1-phosphate uridylyltransferase"
FT                   /id="PRO_0000169922"
SQ   SEQUENCE   519 AA;  60468 MW;  0BF788A4DA08ED75 CRC64;
     MTQKDAAFHI ERLLKFALKK GLIEELDVIP SRNALMDLFK IEKPYEGEVP EEELDTPSPI
     LNKLLDYGVE IGLIEDTVTY RDLMDARIMG LLMPRESEVV RKFNEIASKD GIEKATEYFY
     ELSKASNYIR MDRTSQNLYW RTPTEYGALE ITINLSKPEK DPKEIEKAKK IPQSGYPKCL
     LCIENVGFAG NLNHPARQNL RIIPVKVAGE QWYFQYSPYV YYNEHCILLH EEHIPMKISE
     KTFVRLFDFI DQFPHYFMGS NADLPIVGGS ILVHEHFQGG RHTFPMEEAP IEEYFIHPKY
     KEVKAGILKW PMSVIRLSSK DREKLTKLSS HILNVWKGYS DESVDVLAYS EKDGKIVPHN
     TITPIARFNK EGEYEIDLVL RNNRTTDKYP YGIFHPHEEL HHIKKENIGL IEVMGLAVLP
     GRLKFELEEI RKILTGKEKF NKDMYDENHP LYKHLHWIEE LIVKYGTHCT EEEAENYIKQ
     EVGNKFLQVL LDAGVFKRDE KGKKAFEKFM ETAGFKKLS