ID   GALT_CLOPE              Reviewed;         498 AA.
AC   Q8XKP8;
DT   26-JUL-2002, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2002, sequence version 1.
DT   25-MAY-2022, entry version 98.
DE   RecName: Full=Galactose-1-phosphate uridylyltransferase {ECO:0000255|HAMAP-Rule:MF_00571};
DE            Short=Gal-1-P uridylyltransferase {ECO:0000255|HAMAP-Rule:MF_00571};
DE            EC=2.7.7.12 {ECO:0000255|HAMAP-Rule:MF_00571};
DE   AltName: Full=UDP-glucose--hexose-1-phosphate uridylyltransferase {ECO:0000255|HAMAP-Rule:MF_00571};
GN   Name=galT {ECO:0000255|HAMAP-Rule:MF_00571}; OrderedLocusNames=CPE1346;
OS   Clostridium perfringens (strain 13 / Type A).
OC   Bacteria; Firmicutes; Clostridia; Eubacteriales; Clostridiaceae;
OC   Clostridium.
OX   NCBI_TaxID=195102;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=13 / Type A;
RX   PubMed=11792842; DOI=10.1073/pnas.022493799;
RA   Shimizu T., Ohtani K., Hirakawa H., Ohshima K., Yamashita A., Shiba T.,
RA   Ogasawara N., Hattori M., Kuhara S., Hayashi H.;
RT   "Complete genome sequence of Clostridium perfringens, an anaerobic flesh-
RT   eater.";
RL   Proc. Natl. Acad. Sci. U.S.A. 99:996-1001(2002).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=alpha-D-galactose 1-phosphate + UDP-alpha-D-glucose = alpha-D-
CC         glucose 1-phosphate + UDP-alpha-D-galactose; Xref=Rhea:RHEA:13989,
CC         ChEBI:CHEBI:58336, ChEBI:CHEBI:58601, ChEBI:CHEBI:58885,
CC         ChEBI:CHEBI:66914; EC=2.7.7.12; Evidence={ECO:0000255|HAMAP-
CC         Rule:MF_00571};
CC   -!- PATHWAY: Carbohydrate metabolism; galactose metabolism.
CC       {ECO:0000255|HAMAP-Rule:MF_00571}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_00571}.
CC   -!- SIMILARITY: Belongs to the galactose-1-phosphate uridylyltransferase
CC       type 2 family. {ECO:0000255|HAMAP-Rule:MF_00571}.
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DR   EMBL; BA000016; BAB81052.1; -; Genomic_DNA.
DR   RefSeq; WP_011010402.1; NC_003366.1.
DR   AlphaFoldDB; Q8XKP8; -.
DR   STRING; 195102.gene:10490609; -.
DR   EnsemblBacteria; BAB81052; BAB81052; BAB81052.
DR   KEGG; cpe:CPE1346; -.
DR   HOGENOM; CLU_047799_0_0_9; -.
DR   OMA; IVDWPMS; -.
DR   UniPathway; UPA00214; -.
DR   Proteomes; UP000000818; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0008108; F:UDP-glucose:hexose-1-phosphate uridylyltransferase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0006012; P:galactose metabolic process; IEA:UniProtKB-UniRule.
DR   HAMAP; MF_00571; GalP_UDP_trans; 1.
DR   InterPro; IPR000766; GalP_uridyl_Trfase_II.
DR   InterPro; IPR023425; GalP_uridyl_Trfase_II_CS.
DR   InterPro; IPR005850; GalP_Utransf_C.
DR   InterPro; IPR005849; GalP_Utransf_N.
DR   PANTHER; PTHR39191; PTHR39191; 1.
DR   Pfam; PF02744; GalP_UDP_tr_C; 1.
DR   Pfam; PF01087; GalP_UDP_transf; 1.
DR   PIRSF; PIRSF006005; GalT_BS; 1.
DR   TIGRFAMs; TIGR01239; galT_2; 1.
DR   PROSITE; PS01163; GAL_P_UDP_TRANSF_II; 1.
PE   3: Inferred from homology;
KW   Carbohydrate metabolism; Cytoplasm; Galactose metabolism;
KW   Nucleotidyltransferase; Reference proteome; Transferase.
FT   CHAIN           1..498
FT                   /note="Galactose-1-phosphate uridylyltransferase"
FT                   /id="PRO_0000169903"
SQ   SEQUENCE   498 AA;  57928 MW;  C99AD9BC69C78E11 CRC64;
     MYNLNALIDR LIEISINNNL IEDMDTVYTR NRLLSLFNEN SYTPCEEKLT LSFHETLNEL
     INIAIEKKII ENALYSKDIF SSDIMNIFLP TPSLINKEFY KRYAISPKES TDYFYSLSKS
     SNYIRTDRIA KNINFKAPSK YGTMDITINL SKPEKDPKEI ALARNSVKSN YPKCLLCIEN
     EGYEGTVTHP DRANHRMIRL DLNDRTWMLQ YSPYLYYNEH CIILSEDHVP MKIDISTFKN
     LLSFVDKFPH YFTGSNADLP IVGGSILSHE HYQGGNHRFP MNDAKKLFDF SIEGFEDVEC
     EAIKWPISTI RLRGENIDSL VLASDLILKK WRDYSDETLD ILAYSNSEMH NTITPMVRKE
     DGKFVVDLSL RNNRTSKEHP LGIFHPHEEV HHIKKENIGL IEVMGLAVLP GRLLKELEKI
     KEYLRDEISL DNIEEYHRPW ALELKKKFDY LKSSTDLNDF VNKELSNKFV SVLEHCGVFK
     LNEEGLEGFK RFTNSLNS