ID   GALT_FUSNN              Reviewed;         509 AA.
AC   Q8RHC9;
DT   26-JUL-2002, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-2002, sequence version 1.
DT   03-AUG-2022, entry version 99.
DE   RecName: Full=Galactose-1-phosphate uridylyltransferase {ECO:0000255|HAMAP-Rule:MF_00571};
DE            Short=Gal-1-P uridylyltransferase {ECO:0000255|HAMAP-Rule:MF_00571};
DE            EC=2.7.7.12 {ECO:0000255|HAMAP-Rule:MF_00571};
DE   AltName: Full=UDP-glucose--hexose-1-phosphate uridylyltransferase {ECO:0000255|HAMAP-Rule:MF_00571};
GN   Name=galT {ECO:0000255|HAMAP-Rule:MF_00571}; OrderedLocusNames=FN2108;
OS   Fusobacterium nucleatum subsp. nucleatum (strain ATCC 25586 / DSM 15643 /
OS   BCRC 10681 / CIP 101130 / JCM 8532 / KCTC 2640 / LMG 13131 / VPI 4355).
OC   Bacteria; Fusobacteria; Fusobacteriales; Fusobacteriaceae; Fusobacterium.
OX   NCBI_TaxID=190304;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 25586 / DSM 15643 / BCRC 10681 / CIP 101130 / JCM 8532 / KCTC
RC   2640 / LMG 13131 / VPI 4355;
RX   PubMed=11889109; DOI=10.1128/jb.184.7.2005-2018.2002;
RA   Kapatral V., Anderson I., Ivanova N., Reznik G., Los T., Lykidis A.,
RA   Bhattacharyya A., Bartman A., Gardner W., Grechkin G., Zhu L., Vasieva O.,
RA   Chu L., Kogan Y., Chaga O., Goltsman E., Bernal A., Larsen N., D'Souza M.,
RA   Walunas T., Pusch G., Haselkorn R., Fonstein M., Kyrpides N.C.,
RA   Overbeek R.;
RT   "Genome sequence and analysis of the oral bacterium Fusobacterium nucleatum
RT   strain ATCC 25586.";
RL   J. Bacteriol. 184:2005-2018(2002).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=alpha-D-galactose 1-phosphate + UDP-alpha-D-glucose = alpha-D-
CC         glucose 1-phosphate + UDP-alpha-D-galactose; Xref=Rhea:RHEA:13989,
CC         ChEBI:CHEBI:58336, ChEBI:CHEBI:58601, ChEBI:CHEBI:58885,
CC         ChEBI:CHEBI:66914; EC=2.7.7.12; Evidence={ECO:0000255|HAMAP-
CC         Rule:MF_00571};
CC   -!- PATHWAY: Carbohydrate metabolism; galactose metabolism.
CC       {ECO:0000255|HAMAP-Rule:MF_00571}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_00571}.
CC   -!- SIMILARITY: Belongs to the galactose-1-phosphate uridylyltransferase
CC       type 2 family. {ECO:0000255|HAMAP-Rule:MF_00571}.
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DR   EMBL; AE009951; AAL94192.1; -; Genomic_DNA.
DR   RefSeq; NP_602893.1; NC_003454.1.
DR   AlphaFoldDB; Q8RHC9; -.
DR   STRING; 190304.FN2108; -.
DR   EnsemblBacteria; AAL94192; AAL94192; FN2108.
DR   KEGG; fnu:FN2108; -.
DR   PATRIC; fig|190304.8.peg.570; -.
DR   eggNOG; COG4468; Bacteria.
DR   HOGENOM; CLU_047799_0_0_0; -.
DR   InParanoid; Q8RHC9; -.
DR   OMA; IVDWPMS; -.
DR   BioCyc; FNUC190304:G1FZS-593-MON; -.
DR   UniPathway; UPA00214; -.
DR   Proteomes; UP000002521; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0008108; F:UDP-glucose:hexose-1-phosphate uridylyltransferase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0006012; P:galactose metabolic process; IEA:UniProtKB-UniRule.
DR   HAMAP; MF_00571; GalP_UDP_trans; 1.
DR   InterPro; IPR000766; GalP_uridyl_Trfase_II.
DR   InterPro; IPR023425; GalP_uridyl_Trfase_II_CS.
DR   InterPro; IPR005850; GalP_Utransf_C.
DR   InterPro; IPR005849; GalP_Utransf_N.
DR   PANTHER; PTHR39191; PTHR39191; 1.
DR   Pfam; PF02744; GalP_UDP_tr_C; 1.
DR   Pfam; PF01087; GalP_UDP_transf; 1.
DR   PIRSF; PIRSF006005; GalT_BS; 1.
DR   PROSITE; PS01163; GAL_P_UDP_TRANSF_II; 1.
PE   3: Inferred from homology;
KW   Carbohydrate metabolism; Cytoplasm; Galactose metabolism;
KW   Nucleotidyltransferase; Reference proteome; Transferase.
FT   CHAIN           1..509
FT                   /note="Galactose-1-phosphate uridylyltransferase"
FT                   /id="PRO_0000169905"
SQ   SEQUENCE   509 AA;  59679 MW;  80D270579047FEA1 CRC64;
     MEICSLINRL IKYALKNSLI TEDDVMFVRN ELMALLHLKD WQDVKENCQI PEYPQEILDK
     ICDYAVEQKI IEDGVTDRDI FDTEIMGKFT AFPREIIETF KELSQQNIKL ATDFFYNFSK
     KTNYIRTERI EKNLYWKSLT EYGDLEITIN LSKPEKDPKE IERQKNMPQV NYPKCLLCYE
     NVGFAGTLTH PARQNHRVIP LTLDNERWYF QYSPYVYYNE HAIIFCSEHR EMKINRDTFS
     RTLDFINQFP HYFIGSNADL PIVGGSILSH DHYQGGNHEF PMAKSEIEKE VIFDKYPNIK
     AGIVKWPMSV LRLKSLNRKD LVDLADKTLK AWREYSDEEV GVFAYTNSTP HNTITPIARK
     RGDYFEIDLV LRNNRTDEAN PLGIFHPHSE HHNIKKENIG LIEVMGLAVL PGRLKFEMRK
     IAEYLKDEDF EKKISDDKDT AKHLTWLKAF INKYSNLKTL SVDEILENIL NVEIGLTFSR
     VLEDAGVFKR DEKGKNAFLK FINHIGGRF