ID   GALT_LACCA              Reviewed;         486 AA.
AC   O84904;
DT   26-JUL-2002, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1998, sequence version 1.
DT   25-MAY-2022, entry version 75.
DE   RecName: Full=Galactose-1-phosphate uridylyltransferase {ECO:0000255|HAMAP-Rule:MF_00571};
DE            Short=Gal-1-P uridylyltransferase {ECO:0000255|HAMAP-Rule:MF_00571};
DE            EC=2.7.7.12 {ECO:0000255|HAMAP-Rule:MF_00571};
DE   AltName: Full=UDP-glucose--hexose-1-phosphate uridylyltransferase {ECO:0000255|HAMAP-Rule:MF_00571};
GN   Name=galT {ECO:0000255|HAMAP-Rule:MF_00571};
OS   Lactobacillus casei.
OC   Bacteria; Firmicutes; Bacilli; Lactobacillales; Lactobacillaceae;
OC   Lacticaseibacillus.
OX   NCBI_TaxID=1582;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=64H;
RX   PubMed=9603808; DOI=10.1128/aem.64.6.2013-2019.1998;
RA   Bettenbrock K., Alpert C.-A.;
RT   "The gal genes for the Leloir pathway of Lactobacillus casei 64H.";
RL   Appl. Environ. Microbiol. 64:2013-2019(1998).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=alpha-D-galactose 1-phosphate + UDP-alpha-D-glucose = alpha-D-
CC         glucose 1-phosphate + UDP-alpha-D-galactose; Xref=Rhea:RHEA:13989,
CC         ChEBI:CHEBI:58336, ChEBI:CHEBI:58601, ChEBI:CHEBI:58885,
CC         ChEBI:CHEBI:66914; EC=2.7.7.12; Evidence={ECO:0000255|HAMAP-
CC         Rule:MF_00571};
CC   -!- PATHWAY: Carbohydrate metabolism; galactose metabolism.
CC       {ECO:0000255|HAMAP-Rule:MF_00571}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_00571}.
CC   -!- SIMILARITY: Belongs to the galactose-1-phosphate uridylyltransferase
CC       type 2 family. {ECO:0000255|HAMAP-Rule:MF_00571}.
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DR   EMBL; AF005933; AAC19330.1; -; Genomic_DNA.
DR   AlphaFoldDB; O84904; -.
DR   STRING; 1582.AAW28_10635; -.
DR   eggNOG; COG4468; Bacteria.
DR   UniPathway; UPA00214; -.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0008108; F:UDP-glucose:hexose-1-phosphate uridylyltransferase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0006012; P:galactose metabolic process; IEA:UniProtKB-UniRule.
DR   HAMAP; MF_00571; GalP_UDP_trans; 1.
DR   InterPro; IPR000766; GalP_uridyl_Trfase_II.
DR   InterPro; IPR023425; GalP_uridyl_Trfase_II_CS.
DR   InterPro; IPR005850; GalP_Utransf_C.
DR   InterPro; IPR005849; GalP_Utransf_N.
DR   PANTHER; PTHR39191; PTHR39191; 1.
DR   Pfam; PF02744; GalP_UDP_tr_C; 1.
DR   Pfam; PF01087; GalP_UDP_transf; 1.
DR   PIRSF; PIRSF006005; GalT_BS; 1.
DR   TIGRFAMs; TIGR01239; galT_2; 1.
DR   PROSITE; PS01163; GAL_P_UDP_TRANSF_II; 1.
PE   3: Inferred from homology;
KW   Carbohydrate metabolism; Cytoplasm; Galactose metabolism;
KW   Nucleotidyltransferase; Transferase.
FT   CHAIN           1..486
FT                   /note="Galactose-1-phosphate uridylyltransferase"
FT                   /id="PRO_0000169906"
SQ   SEQUENCE   486 AA;  54162 MW;  91A8EDE4F449B035 CRC64;
     MTAISNHVGT IVKLNPDYTQ MDAVYLTNKL LNLIGDAALD LPGDADPLTN LDLMVKAAQE
     NGKIPDSQAA RQILEAQLMD LATPTPSRIN QLFWDKYQAG PRVATDWFFA LSRANNYIQT
     RAIAKNVVFP AKTEYGDLEI TINLSKPEKD PKDIAAAAHA AQSGYPACAL CLQTEGYAGR
     TDFAARTNHR IIRFLLGGKT WGFQYSPYAY FNEHAIFLDA IHEPMVIDQS TFSNLLSIVS
     MFPTYFVGSN ADLPIVGGSM LTHEHYQGGR HTFPMAKAPI ETQVEISGHP HVFAGIVKWP
     MSVIRLVSAD SDELINAAEH VRQVWNQYTD ETVDVRAFVD GKPHHTVTPI ARRVGSEFQL
     DLVLRDNQTS AEHPDGIFHP HQDVQHIKKE NIGLIEVMGR AILPARLKSE LAEVQKYLLG
     EANTMKPMHK TWADQLKAKY DWTPENVEAQ MQAAVGRVFA RVLEDAGVFK RDEVGQKAFA
     RFCRAL