ID   GALT_LACHE              Reviewed;         488 AA.
AC   Q00054;
DT   01-DEC-1992, integrated into UniProtKB/Swiss-Prot.
DT   01-DEC-1992, sequence version 1.
DT   25-MAY-2022, entry version 88.
DE   RecName: Full=Galactose-1-phosphate uridylyltransferase;
DE            Short=Gal-1-P uridylyltransferase;
DE            EC=2.7.7.12;
DE   AltName: Full=UDP-glucose--hexose-1-phosphate uridylyltransferase;
GN   Name=galT;
OS   Lactobacillus helveticus (Lactobacillus suntoryeus).
OC   Bacteria; Firmicutes; Bacilli; Lactobacillales; Lactobacillaceae;
OC   Lactobacillus.
OX   NCBI_TaxID=1587;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=ATCC 15009 / DSM 20075 / BCRC 12936 / JCM 1120 / NBRC 15019 / NCIMB
RC   11971 / NRRL B-4526 / Lh12;
RX   PubMed=2066342; DOI=10.1128/jb.173.14.4464-4473.1991;
RA   Mollet B., Pilloud N.;
RT   "Galactose utilization in Lactobacillus helveticus: isolation and
RT   characterization of the galactokinase (galK) and galactose-1-phosphate
RT   uridyl transferase (galT) genes.";
RL   J. Bacteriol. 173:4464-4473(1991).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=alpha-D-galactose 1-phosphate + UDP-alpha-D-glucose = alpha-D-
CC         glucose 1-phosphate + UDP-alpha-D-galactose; Xref=Rhea:RHEA:13989,
CC         ChEBI:CHEBI:58336, ChEBI:CHEBI:58601, ChEBI:CHEBI:58885,
CC         ChEBI:CHEBI:66914; EC=2.7.7.12;
CC   -!- PATHWAY: Carbohydrate metabolism; galactose metabolism.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the galactose-1-phosphate uridylyltransferase
CC       type 2 family. {ECO:0000305}.
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DR   EMBL; X57248; CAA40526.1; -; Genomic_DNA.
DR   PIR; B47032; B47032.
DR   RefSeq; WP_003627706.1; NZ_WCHE01000033.1.
DR   AlphaFoldDB; Q00054; -.
DR   STRING; 326425.lhe_1409; -.
DR   GeneID; 66452627; -.
DR   PATRIC; fig|1587.23.peg.1835; -.
DR   eggNOG; COG4468; Bacteria.
DR   UniPathway; UPA00214; -.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0008108; F:UDP-glucose:hexose-1-phosphate uridylyltransferase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0006012; P:galactose metabolic process; IEA:UniProtKB-UniRule.
DR   HAMAP; MF_00571; GalP_UDP_trans; 1.
DR   InterPro; IPR000766; GalP_uridyl_Trfase_II.
DR   InterPro; IPR023425; GalP_uridyl_Trfase_II_CS.
DR   InterPro; IPR005850; GalP_Utransf_C.
DR   InterPro; IPR005849; GalP_Utransf_N.
DR   PANTHER; PTHR39191; PTHR39191; 1.
DR   Pfam; PF02744; GalP_UDP_tr_C; 1.
DR   Pfam; PF01087; GalP_UDP_transf; 1.
DR   PIRSF; PIRSF006005; GalT_BS; 1.
DR   PROSITE; PS01163; GAL_P_UDP_TRANSF_II; 1.
PE   3: Inferred from homology;
KW   Carbohydrate metabolism; Cytoplasm; Galactose metabolism;
KW   Nucleotidyltransferase; Transferase.
FT   CHAIN           1..488
FT                   /note="Galactose-1-phosphate uridylyltransferase"
FT                   /id="PRO_0000169907"
SQ   SEQUENCE   488 AA;  55607 MW;  A4117D88D0A9C0A5 CRC64;
     MKIIEKFADE VINSGAYEPL DRVYVINKIR ALVGDHDEEE ENDQPAAKQL VDLAVKNEKI
     PDDITSREVL NDQLYDLATP TPSKTNSIFW QKMQKSSEEN TDWFYKLCED NNYVKKEAIA
     KNVVFSGTSS KGHSLEITIN LSKPEKDPKA IAAAAHATGK KYPQCALCLE NEGYLGGYGK
     NARSNLRIIR MNIAGRPWGF QYSPYAYFNE HCIFLDQKHI PMVINQQTLI NLVEIEKIFP
     HYFVGSNADL PIVGGSMLAH EHYQGGRHTF PMMKAGIKKN IMFDSYPKVV AGIVDWPMSD
     LRLTSDNSLD LIDLGSKIIK FWDNYSDTAR DIKAYEGETR HHTVTPIMHR EGKNFVLDLV
     LRDNNTSEKY PLGIFHPHKQ LWHIKKENIG LIEVMGRAIL PGRLKSELEE VKKYWLGEDN
     KMAASHKEWA DQVKAENEIS LDNVDQVMEQ SLVEVFEQVL QDAGVFKNNA DGEEGWDKFI
     TALTKEIK