ID   GALT_LACLA              Reviewed;         493 AA.
AC   Q9CE63; O87522;
DT   23-JAN-2002, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-2001, sequence version 1.
DT   25-MAY-2022, entry version 110.
DE   RecName: Full=Galactose-1-phosphate uridylyltransferase;
DE            Short=Gal-1-P uridylyltransferase;
DE            EC=2.7.7.12;
DE   AltName: Full=UDP-glucose--hexose-1-phosphate uridylyltransferase;
GN   Name=galT; OrderedLocusNames=LL1982; ORFNames=L0027;
OS   Lactococcus lactis subsp. lactis (strain IL1403) (Streptococcus lactis).
OC   Bacteria; Firmicutes; Bacilli; Lactobacillales; Streptococcaceae;
OC   Lactococcus.
OX   NCBI_TaxID=272623;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=NCDO 2054;
RX   PubMed=9733693; DOI=10.1128/jb.180.18.4893-4902.1998;
RA   Vaughan E.E., Pridmore R.D., Mollet B.;
RT   "Transcriptional regulation and evolution of lactose genes in the
RT   galactose-lactose operon of Lactococcus lactis NCDO2054.";
RL   J. Bacteriol. 180:4893-4902(1998).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=ATCC 7962;
RA   Lee J.M., Chung D.K., Park J.H., Lee W.K., Chang H.C., Kim J.H., Lee H.J.;
RT   "The organization of genes involved in metabolism of gal/lac of Lactococcus
RT   lactis.";
RL   Submitted (FEB-1999) to the EMBL/GenBank/DDBJ databases.
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=IL1403;
RX   PubMed=11337471; DOI=10.1101/gr.gr-1697r;
RA   Bolotin A., Wincker P., Mauger S., Jaillon O., Malarme K., Weissenbach J.,
RA   Ehrlich S.D., Sorokin A.;
RT   "The complete genome sequence of the lactic acid bacterium Lactococcus
RT   lactis ssp. lactis IL1403.";
RL   Genome Res. 11:731-753(2001).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=alpha-D-galactose 1-phosphate + UDP-alpha-D-glucose = alpha-D-
CC         glucose 1-phosphate + UDP-alpha-D-galactose; Xref=Rhea:RHEA:13989,
CC         ChEBI:CHEBI:58336, ChEBI:CHEBI:58601, ChEBI:CHEBI:58885,
CC         ChEBI:CHEBI:66914; EC=2.7.7.12;
CC   -!- PATHWAY: Carbohydrate metabolism; galactose metabolism.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the galactose-1-phosphate uridylyltransferase
CC       type 2 family. {ECO:0000305}.
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DR   EMBL; AF082008; AAC63018.1; -; Genomic_DNA.
DR   EMBL; U60828; AAD11511.1; -; Genomic_DNA.
DR   EMBL; AE005176; AAK06080.1; -; Genomic_DNA.
DR   PIR; F86872; F86872.
DR   RefSeq; NP_268139.1; NC_002662.1.
DR   RefSeq; WP_010906248.1; NC_002662.1.
DR   AlphaFoldDB; Q9CE63; -.
DR   STRING; 272623.L0027; -.
DR   PaxDb; Q9CE63; -.
DR   EnsemblBacteria; AAK06080; AAK06080; L0027.
DR   KEGG; lla:L0027; -.
DR   PATRIC; fig|272623.7.peg.2135; -.
DR   eggNOG; COG4468; Bacteria.
DR   HOGENOM; CLU_047799_0_0_9; -.
DR   OMA; IVDWPMS; -.
DR   UniPathway; UPA00214; -.
DR   Proteomes; UP000002196; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0008108; F:UDP-glucose:hexose-1-phosphate uridylyltransferase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0006012; P:galactose metabolic process; IEA:UniProtKB-UniRule.
DR   HAMAP; MF_00571; GalP_UDP_trans; 1.
DR   InterPro; IPR000766; GalP_uridyl_Trfase_II.
DR   InterPro; IPR023425; GalP_uridyl_Trfase_II_CS.
DR   InterPro; IPR005850; GalP_Utransf_C.
DR   InterPro; IPR005849; GalP_Utransf_N.
DR   PANTHER; PTHR39191; PTHR39191; 1.
DR   Pfam; PF02744; GalP_UDP_tr_C; 1.
DR   Pfam; PF01087; GalP_UDP_transf; 1.
DR   PIRSF; PIRSF006005; GalT_BS; 1.
DR   TIGRFAMs; TIGR01239; galT_2; 1.
DR   PROSITE; PS01163; GAL_P_UDP_TRANSF_II; 1.
PE   3: Inferred from homology;
KW   Carbohydrate metabolism; Cytoplasm; Galactose metabolism;
KW   Nucleotidyltransferase; Reference proteome; Transferase.
FT   CHAIN           1..493
FT                   /note="Galactose-1-phosphate uridylyltransferase"
FT                   /id="PRO_0000169908"
FT   VARIANT         95
FT                   /note="Q -> H (in strain: ATCC 7962 and NCDO 2054)"
FT   VARIANT         128
FT                   /note="T -> A (in strain: ATCC 7962 and NCDO 2054)"
FT   VARIANT         435
FT                   /note="K -> R (in strain: ATCC 7962 and NCDO 2054)"
SQ   SEQUENCE   493 AA;  56555 MW;  5CED96D1B89E48C2 CRC64;
     MSIYQSIQDF ISLALQNGTI EPLDELYHRN QLLHFLGLND WAEVDKEAHE KDSLILMDQL
     LAIANENNVI EKGQDEFYEA ALMNFITPRP SKINQDFWEK YKTSPDAATQ YFYELAQQVN
     QVKTRDITRN IAFSHLTKYG KLEITINLSK PEKDPKAIAA AKLVKASSYP ACQLCLENEG
     FYGIGNKPAR SNHRIIQVSI NGEDWGFQYS PYAYFNEHSI LLNAKHQPME INKRAFDNLL
     GFLDQFPDYM IGSNADLPIV GGSILTHDHY QAGRYEFPMA KAELREEIKL QQFPEVSCGI
     VNWPMSVLRL SSKNQVELSK AADELLKKWQ VYSDESLQIK AKSADGKLHH TITPIARIRE
     GKYELDLVLR DNNTSEIYPD GIFHPHPALH HIKKENIGLI EVMGLAILPA RLKTELLEVE
     KYLLNQENEM SEIHKPWAEE LKETEYFSKE TVHETVQEAV GEVFEQVLKD AGVFKDNEVG
     QKGFYEFINF VNN