ID   GALT_LACLM              Reviewed;         493 AA.
AC   Q9S6S3; A2RNB3;
DT   26-JUL-2002, integrated into UniProtKB/Swiss-Prot.
DT   01-MAY-2000, sequence version 1.
DT   03-AUG-2022, entry version 106.
DE   RecName: Full=Galactose-1-phosphate uridylyltransferase {ECO:0000255|HAMAP-Rule:MF_00571};
DE            Short=Gal-1-P uridylyltransferase {ECO:0000255|HAMAP-Rule:MF_00571};
DE            EC=2.7.7.12 {ECO:0000255|HAMAP-Rule:MF_00571};
DE   AltName: Full=UDP-glucose--hexose-1-phosphate uridylyltransferase {ECO:0000255|HAMAP-Rule:MF_00571};
GN   Name=galT {ECO:0000255|HAMAP-Rule:MF_00571}; OrderedLocusNames=llmg_2234;
OS   Lactococcus lactis subsp. cremoris (strain MG1363).
OC   Bacteria; Firmicutes; Bacilli; Lactobacillales; Streptococcaceae;
OC   Lactococcus; Lactococcus cremoris subsp. cremoris.
OX   NCBI_TaxID=416870;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RA   Grossiord B.P., Luesink E.J., Vaughan E.E., Kuipers O.P., De Vos W.M.;
RT   "Characterization, expression and mutations of the Lactococcus lactis
RT   galAMKTE genes involved in galactose utilization via the Leloir pathway.";
RL   Submitted (SEP-1998) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=MG1363;
RX   PubMed=17307855; DOI=10.1128/jb.01768-06;
RA   Wegmann U., O'Connell-Motherway M., Zomer A., Buist G., Shearman C.,
RA   Canchaya C., Ventura M., Goesmann A., Gasson M.J., Kuipers O.P.,
RA   van Sinderen D., Kok J.;
RT   "The complete genome sequence of the lactic acid bacterial paradigm
RT   Lactococcus lactis subsp. cremoris MG1363.";
RL   J. Bacteriol. 189:3256-3270(2007).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=alpha-D-galactose 1-phosphate + UDP-alpha-D-glucose = alpha-D-
CC         glucose 1-phosphate + UDP-alpha-D-galactose; Xref=Rhea:RHEA:13989,
CC         ChEBI:CHEBI:58336, ChEBI:CHEBI:58601, ChEBI:CHEBI:58885,
CC         ChEBI:CHEBI:66914; EC=2.7.7.12; Evidence={ECO:0000255|HAMAP-
CC         Rule:MF_00571};
CC   -!- PATHWAY: Carbohydrate metabolism; galactose metabolism.
CC       {ECO:0000255|HAMAP-Rule:MF_00571}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_00571}.
CC   -!- SIMILARITY: Belongs to the galactose-1-phosphate uridylyltransferase
CC       type 2 family. {ECO:0000255|HAMAP-Rule:MF_00571}.
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DR   EMBL; AJ011653; CAB44217.1; -; Genomic_DNA.
DR   EMBL; AM406671; CAL98801.1; -; Genomic_DNA.
DR   RefSeq; WP_011835925.1; NZ_WJVF01000009.1.
DR   AlphaFoldDB; Q9S6S3; -.
DR   STRING; 416870.llmg_2234; -.
DR   EnsemblBacteria; CAL98801; CAL98801; llmg_2234.
DR   KEGG; llm:llmg_2234; -.
DR   eggNOG; COG4468; Bacteria.
DR   HOGENOM; CLU_047799_0_0_9; -.
DR   OMA; YEKHVPM; -.
DR   PhylomeDB; Q9S6S3; -.
DR   BioCyc; LLAC416870:LLMG_RS11205-MON; -.
DR   UniPathway; UPA00214; -.
DR   Proteomes; UP000000364; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0008108; F:UDP-glucose:hexose-1-phosphate uridylyltransferase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0006012; P:galactose metabolic process; IEA:UniProtKB-UniRule.
DR   HAMAP; MF_00571; GalP_UDP_trans; 1.
DR   InterPro; IPR000766; GalP_uridyl_Trfase_II.
DR   InterPro; IPR023425; GalP_uridyl_Trfase_II_CS.
DR   InterPro; IPR005850; GalP_Utransf_C.
DR   InterPro; IPR005849; GalP_Utransf_N.
DR   PANTHER; PTHR39191; PTHR39191; 1.
DR   Pfam; PF02744; GalP_UDP_tr_C; 1.
DR   Pfam; PF01087; GalP_UDP_transf; 1.
DR   PIRSF; PIRSF006005; GalT_BS; 1.
DR   TIGRFAMs; TIGR01239; galT_2; 1.
DR   PROSITE; PS01163; GAL_P_UDP_TRANSF_II; 1.
PE   3: Inferred from homology;
KW   Carbohydrate metabolism; Cytoplasm; Galactose metabolism;
KW   Nucleotidyltransferase; Transferase.
FT   CHAIN           1..493
FT                   /note="Galactose-1-phosphate uridylyltransferase"
FT                   /id="PRO_0000169909"
SQ   SEQUENCE   493 AA;  56260 MW;  05BFA76B3F6E5022 CRC64;
     MSIYQSIQDF ISLALQNGTI EPLDELYHRN QLLHFLGLND WAEVDKEVHE TNSLILMDQL
     LAIANENNVI AKGQDEFYEA ALMNFMTPRP SKINHDFWEK YQASPDDATQ YFYELAQQVN
     QVKTRDIARN IAFSHLTKYG KLEITINLSK PEKDPKAIAA AKLVKASSYP ACQLCLENEG
     FYGLGNKPAR SNHRIIQVSI NGEDWGFQYS PYAYFNEHSI LLNAKHQPME INKRAFDNLL
     GFLDKFPNYM IGSNADLPIV GGSILTHDHY QAGRHDFPMA KAELRETIEL AHFPEVSCGI
     VNWPMSVLRL ASENQVELSK AADDFLKKWQ VYSDESLQIK AKSTDGTPHH TITPIARIRD
     GKYELDLVLR DNNTNEKYPD GIFHPHPALH HIKKENIGLI EVMGLAILPA RLGTELLEVE
     KYLLNQDNQM DEIHKAWAEQ LKNEEHFTRE TVHATVQGAV GEVFEEVLKD AGVFKDTQEG
     HEGFRKFIDF VNQ