ID   GALT_LACPL              Reviewed;         487 AA.
AC   Q88SF0; F9UUE6;
DT   06-JUN-2003, integrated into UniProtKB/Swiss-Prot.
DT   06-JUN-2003, sequence version 1.
DT   03-AUG-2022, entry version 94.
DE   RecName: Full=Galactose-1-phosphate uridylyltransferase {ECO:0000255|HAMAP-Rule:MF_00571};
DE            Short=Gal-1-P uridylyltransferase {ECO:0000255|HAMAP-Rule:MF_00571};
DE            EC=2.7.7.12 {ECO:0000255|HAMAP-Rule:MF_00571};
DE   AltName: Full=UDP-glucose--hexose-1-phosphate uridylyltransferase {ECO:0000255|HAMAP-Rule:MF_00571};
GN   Name=galT {ECO:0000255|HAMAP-Rule:MF_00571}; OrderedLocusNames=lp_3480;
OS   Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)
OS   (Lactobacillus plantarum).
OC   Bacteria; Firmicutes; Bacilli; Lactobacillales; Lactobacillaceae;
OC   Lactiplantibacillus.
OX   NCBI_TaxID=220668;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC BAA-793 / NCIMB 8826 / WCFS1;
RX   PubMed=12566566; DOI=10.1073/pnas.0337704100;
RA   Kleerebezem M., Boekhorst J., van Kranenburg R., Molenaar D., Kuipers O.P.,
RA   Leer R., Tarchini R., Peters S.A., Sandbrink H.M., Fiers M.W.E.J.,
RA   Stiekema W., Klein Lankhorst R.M., Bron P.A., Hoffer S.M.,
RA   Nierop Groot M.N., Kerkhoven R., De Vries M., Ursing B., De Vos W.M.,
RA   Siezen R.J.;
RT   "Complete genome sequence of Lactobacillus plantarum WCFS1.";
RL   Proc. Natl. Acad. Sci. U.S.A. 100:1990-1995(2003).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], AND GENOME REANNOTATION.
RC   STRAIN=ATCC BAA-793 / NCIMB 8826 / WCFS1;
RX   PubMed=22156394; DOI=10.1128/jb.06275-11;
RA   Siezen R.J., Francke C., Renckens B., Boekhorst J., Wels M.,
RA   Kleerebezem M., van Hijum S.A.;
RT   "Complete resequencing and reannotation of the Lactobacillus plantarum
RT   WCFS1 genome.";
RL   J. Bacteriol. 194:195-196(2012).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=alpha-D-galactose 1-phosphate + UDP-alpha-D-glucose = alpha-D-
CC         glucose 1-phosphate + UDP-alpha-D-galactose; Xref=Rhea:RHEA:13989,
CC         ChEBI:CHEBI:58336, ChEBI:CHEBI:58601, ChEBI:CHEBI:58885,
CC         ChEBI:CHEBI:66914; EC=2.7.7.12; Evidence={ECO:0000255|HAMAP-
CC         Rule:MF_00571};
CC   -!- PATHWAY: Carbohydrate metabolism; galactose metabolism.
CC       {ECO:0000255|HAMAP-Rule:MF_00571}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_00571}.
CC   -!- SIMILARITY: Belongs to the galactose-1-phosphate uridylyltransferase
CC       type 2 family. {ECO:0000255|HAMAP-Rule:MF_00571}.
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DR   EMBL; AL935263; CCC80448.1; -; Genomic_DNA.
DR   RefSeq; WP_011102180.1; NC_004567.2.
DR   RefSeq; YP_004890962.1; NC_004567.2.
DR   AlphaFoldDB; Q88SF0; -.
DR   STRING; 220668.lp_3480; -.
DR   PRIDE; Q88SF0; -.
DR   EnsemblBacteria; CCC80448; CCC80448; lp_3480.
DR   KEGG; lpl:lp_3480; -.
DR   PATRIC; fig|220668.9.peg.2896; -.
DR   eggNOG; COG4468; Bacteria.
DR   HOGENOM; CLU_047799_0_0_9; -.
DR   OMA; IVDWPMS; -.
DR   PhylomeDB; Q88SF0; -.
DR   BioCyc; LPLA220668:G1GW0-2936-MON; -.
DR   UniPathway; UPA00214; -.
DR   Proteomes; UP000000432; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0008108; F:UDP-glucose:hexose-1-phosphate uridylyltransferase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0006012; P:galactose metabolic process; IEA:UniProtKB-UniRule.
DR   HAMAP; MF_00571; GalP_UDP_trans; 1.
DR   InterPro; IPR000766; GalP_uridyl_Trfase_II.
DR   InterPro; IPR023425; GalP_uridyl_Trfase_II_CS.
DR   InterPro; IPR005850; GalP_Utransf_C.
DR   InterPro; IPR005849; GalP_Utransf_N.
DR   PANTHER; PTHR39191; PTHR39191; 1.
DR   Pfam; PF02744; GalP_UDP_tr_C; 1.
DR   Pfam; PF01087; GalP_UDP_transf; 1.
DR   PIRSF; PIRSF006005; GalT_BS; 1.
DR   TIGRFAMs; TIGR01239; galT_2; 1.
DR   PROSITE; PS01163; GAL_P_UDP_TRANSF_II; 1.
PE   3: Inferred from homology;
KW   Carbohydrate metabolism; Cytoplasm; Galactose metabolism;
KW   Nucleotidyltransferase; Reference proteome; Transferase.
FT   CHAIN           1..487
FT                   /note="Galactose-1-phosphate uridylyltransferase"
FT                   /id="PRO_0000169910"
SQ   SEQUENCE   487 AA;  54243 MW;  70748FD7C6277E8B CRC64;
     MTSLDQFVTA VIASPSQYTE LDRIYVHNRV LGLVGEGDPI AASDDQLTSL TDALVKTAIQ
     NGKIEATQSD EDILADQLMD LVTPLPSVLN QRFWDKYQVS PQTATDYFFN LSKANDYIKT
     RAIAKNVVFP AKTPFGDLEI TINLSKPEKD PKAIAAARNQ PQDGYPLCQL CMQNEGYLGR
     LGYPARSNHR IIRLTLGGNT WGFQYSPYAY FNEHSIFLDQ EHRPMVINRQ TFTNLLEIVQ
     QFPHYFVGSN ADLPIVGGSM LSHEHYQGGR HEFPMMKAPI ARTIDLGIAG VKAGIVKWPM
     STIRLTSQDL VALTDAAVKI HETWKNYSDE SVDVRAYTDG TRHHTTTPIA RKVGDDYVLD
     IVLRDNQTSA EFPDGIFHPH QDVQHIKKEN IGLIEVMGRA ILPARLKTEL AEVGKYLLDQ
     PNQMVAMHQA WAAQLKATNT ITADNVTTVI DTAVGNVFAR VLADAGVFKW DDAGEAAFDR
     FVAAMHD