ID   GALT_LATSS              Reviewed;         498 AA.
AC   Q93MM1; Q38XL0;
DT   26-JUL-2002, integrated into UniProtKB/Swiss-Prot.
DT   01-DEC-2001, sequence version 1.
DT   03-AUG-2022, entry version 105.
DE   RecName: Full=Galactose-1-phosphate uridylyltransferase {ECO:0000255|HAMAP-Rule:MF_00571};
DE            Short=Gal-1-P uridylyltransferase {ECO:0000255|HAMAP-Rule:MF_00571};
DE            EC=2.7.7.12 {ECO:0000255|HAMAP-Rule:MF_00571};
DE   AltName: Full=UDP-glucose--hexose-1-phosphate uridylyltransferase {ECO:0000255|HAMAP-Rule:MF_00571};
GN   Name=galT {ECO:0000255|HAMAP-Rule:MF_00571}; OrderedLocusNames=LCA_0766;
OS   Latilactobacillus sakei subsp. sakei (strain 23K) (Lactobacillus sakei
OS   subsp. sakei).
OC   Bacteria; Firmicutes; Bacilli; Lactobacillales; Lactobacillaceae;
OC   Latilactobacillus.
OX   NCBI_TaxID=314315;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=11832506; DOI=10.1099/00221287-148-2-421;
RA   Dudez A.-M., Chaillou S., Hissler L., Stentz R., Champomier-Verges M.-C.,
RA   Alpert C.-A., Zagorec M.;
RT   "Physical and genetic map of the Lactobacillus sakei 23K chromosome.";
RL   Microbiology 148:421-431(2002).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=23K;
RX   PubMed=16273110; DOI=10.1038/nbt1160;
RA   Chaillou S., Champomier-Verges M.-C., Cornet M., Crutz-Le Coq A.-M.,
RA   Dudez A.-M., Martin V., Beaufils S., Darbon-Rongere E., Bossy R., Loux V.,
RA   Zagorec M.;
RT   "The complete genome sequence of the meat-borne lactic acid bacterium
RT   Lactobacillus sakei 23K.";
RL   Nat. Biotechnol. 23:1527-1533(2005).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=alpha-D-galactose 1-phosphate + UDP-alpha-D-glucose = alpha-D-
CC         glucose 1-phosphate + UDP-alpha-D-galactose; Xref=Rhea:RHEA:13989,
CC         ChEBI:CHEBI:58336, ChEBI:CHEBI:58601, ChEBI:CHEBI:58885,
CC         ChEBI:CHEBI:66914; EC=2.7.7.12; Evidence={ECO:0000255|HAMAP-
CC         Rule:MF_00571};
CC   -!- PATHWAY: Carbohydrate metabolism; galactose metabolism.
CC       {ECO:0000255|HAMAP-Rule:MF_00571}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_00571}.
CC   -!- SIMILARITY: Belongs to the galactose-1-phosphate uridylyltransferase
CC       type 2 family. {ECO:0000255|HAMAP-Rule:MF_00571}.
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DR   EMBL; AF401040; AAK92518.1; -; Genomic_DNA.
DR   EMBL; CR936503; CAI55070.1; -; Genomic_DNA.
DR   RefSeq; WP_011374473.1; NC_007576.1.
DR   AlphaFoldDB; Q93MM1; -.
DR   STRING; 314315.LCA_0766; -.
DR   PRIDE; Q93MM1; -.
DR   EnsemblBacteria; CAI55070; CAI55070; LCA_0766.
DR   KEGG; lsa:LCA_0766; -.
DR   eggNOG; COG4468; Bacteria.
DR   HOGENOM; CLU_047799_0_0_9; -.
DR   OMA; IVDWPMS; -.
DR   OrthoDB; 801432at2; -.
DR   BioCyc; LSAK314315:LCA_RS03870-MON; -.
DR   UniPathway; UPA00214; -.
DR   Proteomes; UP000002707; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0008108; F:UDP-glucose:hexose-1-phosphate uridylyltransferase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0006012; P:galactose metabolic process; IEA:UniProtKB-UniRule.
DR   HAMAP; MF_00571; GalP_UDP_trans; 1.
DR   InterPro; IPR000766; GalP_uridyl_Trfase_II.
DR   InterPro; IPR023425; GalP_uridyl_Trfase_II_CS.
DR   InterPro; IPR005850; GalP_Utransf_C.
DR   InterPro; IPR005849; GalP_Utransf_N.
DR   PANTHER; PTHR39191; PTHR39191; 1.
DR   Pfam; PF02744; GalP_UDP_tr_C; 1.
DR   Pfam; PF01087; GalP_UDP_transf; 1.
DR   PIRSF; PIRSF006005; GalT_BS; 1.
DR   TIGRFAMs; TIGR01239; galT_2; 1.
DR   PROSITE; PS01163; GAL_P_UDP_TRANSF_II; 1.
PE   3: Inferred from homology;
KW   Carbohydrate metabolism; Cytoplasm; Galactose metabolism;
KW   Nucleotidyltransferase; Reference proteome; Transferase.
FT   CHAIN           1..498
FT                   /note="Galactose-1-phosphate uridylyltransferase"
FT                   /id="PRO_0000169911"
SQ   SEQUENCE   498 AA;  56295 MW;  065C761B38205663 CRC64;
     MQARELIQKF ITKVSTFPET TYTAEDEQYL FNVVLDLVGE GDETPVVAQE TTTLIDLKEA
     LVQLAVDHQR IQDLAAERDI LGAKLMDLVT PLPSAVNKRF WTLYEKDPEK ALAYFYELSQ
     ANDYIKVAAI AKNIAYDVPT KYGDLEITIN LSKPEKDPKQ IALAKTMKQT GYPKCQLCLE
     NEGYAGRLDF PARRNHRIVR FDLEQQTWGF QYSPYAYFNE HSIFLDGKHE PMVIDQTTFK
     NLLQIVKQFP GYFAGSNADL PIVGGSILTH EHYQGGRHDF PMAKAPISTP LQFAGYDDIQ
     AGIVEWPMSV MRLTGSDAKR IETLAADILT KWQHYSDPEV QVLAQEADGT PHHTITPIAR
     MRGDQYEIDL VLRDNQTSPE HPDGIYHPHA DVQHIKKENI GLIEVMGLAI LPPRLKSEMA
     EVEKYLCDQP NEMAAYHKTW ADQIKADHSA ITPANVTTLV QNEVGKVFMR VLEDAGVFKR
     DAKGQAAFIK FTERVNNA