ID   GALT_LIGS1              Reviewed;         495 AA.
AC   Q1WUZ2;
DT   15-JAN-2008, integrated into UniProtKB/Swiss-Prot.
DT   02-MAY-2006, sequence version 1.
DT   25-MAY-2022, entry version 77.
DE   RecName: Full=Galactose-1-phosphate uridylyltransferase {ECO:0000255|HAMAP-Rule:MF_00571};
DE            Short=Gal-1-P uridylyltransferase {ECO:0000255|HAMAP-Rule:MF_00571};
DE            EC=2.7.7.12 {ECO:0000255|HAMAP-Rule:MF_00571};
DE   AltName: Full=UDP-glucose--hexose-1-phosphate uridylyltransferase {ECO:0000255|HAMAP-Rule:MF_00571};
GN   Name=galT {ECO:0000255|HAMAP-Rule:MF_00571}; OrderedLocusNames=LSL_0383;
OS   Ligilactobacillus salivarius (strain UCC118) (Lactobacillus salivarius).
OC   Bacteria; Firmicutes; Bacilli; Lactobacillales; Lactobacillaceae;
OC   Ligilactobacillus.
OX   NCBI_TaxID=362948;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=UCC118;
RX   PubMed=16617113; DOI=10.1073/pnas.0511060103;
RA   Claesson M.J., Li Y., Leahy S., Canchaya C., van Pijkeren J.P.,
RA   Cerdeno-Tarraga A.M., Parkhill J., Flynn S., O'Sullivan G.C., Collins J.K.,
RA   Higgins D., Shanahan F., Fitzgerald G.F., van Sinderen D., O'Toole P.W.;
RT   "Multireplicon genome architecture of Lactobacillus salivarius.";
RL   Proc. Natl. Acad. Sci. U.S.A. 103:6718-6723(2006).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=alpha-D-galactose 1-phosphate + UDP-alpha-D-glucose = alpha-D-
CC         glucose 1-phosphate + UDP-alpha-D-galactose; Xref=Rhea:RHEA:13989,
CC         ChEBI:CHEBI:58336, ChEBI:CHEBI:58601, ChEBI:CHEBI:58885,
CC         ChEBI:CHEBI:66914; EC=2.7.7.12; Evidence={ECO:0000255|HAMAP-
CC         Rule:MF_00571};
CC   -!- PATHWAY: Carbohydrate metabolism; galactose metabolism.
CC       {ECO:0000255|HAMAP-Rule:MF_00571}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_00571}.
CC   -!- SIMILARITY: Belongs to the galactose-1-phosphate uridylyltransferase
CC       type 2 family. {ECO:0000255|HAMAP-Rule:MF_00571}.
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DR   EMBL; CP000233; ABD99193.1; -; Genomic_DNA.
DR   RefSeq; WP_011475726.1; NC_007929.1.
DR   RefSeq; YP_535276.1; NC_007929.1.
DR   AlphaFoldDB; Q1WUZ2; -.
DR   STRING; 362948.LSL_0383; -.
DR   EnsemblBacteria; ABD99193; ABD99193; LSL_0383.
DR   KEGG; lsl:LSL_0383; -.
DR   PATRIC; fig|362948.14.peg.460; -.
DR   HOGENOM; CLU_047799_0_0_9; -.
DR   OMA; IVDWPMS; -.
DR   UniPathway; UPA00214; -.
DR   Proteomes; UP000006559; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0008108; F:UDP-glucose:hexose-1-phosphate uridylyltransferase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0006012; P:galactose metabolic process; IEA:UniProtKB-UniRule.
DR   HAMAP; MF_00571; GalP_UDP_trans; 1.
DR   InterPro; IPR000766; GalP_uridyl_Trfase_II.
DR   InterPro; IPR023425; GalP_uridyl_Trfase_II_CS.
DR   InterPro; IPR005850; GalP_Utransf_C.
DR   InterPro; IPR005849; GalP_Utransf_N.
DR   PANTHER; PTHR39191; PTHR39191; 1.
DR   Pfam; PF02744; GalP_UDP_tr_C; 1.
DR   Pfam; PF01087; GalP_UDP_transf; 1.
DR   PIRSF; PIRSF006005; GalT_BS; 1.
DR   TIGRFAMs; TIGR01239; galT_2; 1.
DR   PROSITE; PS01163; GAL_P_UDP_TRANSF_II; 1.
PE   3: Inferred from homology;
KW   Carbohydrate metabolism; Cytoplasm; Galactose metabolism;
KW   Nucleotidyltransferase; Reference proteome; Transferase.
FT   CHAIN           1..495
FT                   /note="Galactose-1-phosphate uridylyltransferase"
FT                   /id="PRO_1000025025"
SQ   SEQUENCE   495 AA;  57093 MW;  4C22552BF607AF0C CRC64;
     MDDKLLLDTF IKQVIEQENY TELDRNYLYN RILNLVGEGV EKLTTTKNEI IDLKNELVEY
     AVQHGKVGET LNEQDCLGAE LMNFITPLPS KVNQDFWQTY QQKSPEEAIQ NFYDLSKRND
     YIKTKAIAKN IYFPVETSYG QLEITINLSK PEKDPKQIAL AKKMKASGYP LCQLCMENEG
     YQGRINYPAR ANHRIIRFDL DDKQWGFQYS PYAYFNEHCI FLDTIHEPME ITKQTFNNLL
     GIIEQFPGYF VGSNADLPIV GGSILTHEHY QGGRHTFAME KAPIETELKF AGYEDIQAGI
     VKWPMSVIRL RGNSKEDLVD LADKILKTWR GYSDEEVSVL AESNGEKHHT ITPIARKRDG
     QLELDLVLRD NQTSEQYPDG IYHPHPDVQH IKKENIGLIE VMGLAILPPR LKGELQEVEK
     YLLGQENKME EYHQVWADDI KQKYSDISQE NVGTIIQQEL GRVFARVLED AGVYKHDETG
     RMAFKRFVEE VGIVD