ID   GALT_STACT              Reviewed;         498 AA.
AC   Q9RGR9; B9DLZ4;
DT   26-JUL-2002, integrated into UniProtKB/Swiss-Prot.
DT   01-MAY-2000, sequence version 1.
DT   03-AUG-2022, entry version 109.
DE   RecName: Full=Galactose-1-phosphate uridylyltransferase {ECO:0000255|HAMAP-Rule:MF_00571};
DE            Short=Gal-1-P uridylyltransferase {ECO:0000255|HAMAP-Rule:MF_00571};
DE            EC=2.7.7.12 {ECO:0000255|HAMAP-Rule:MF_00571};
DE   AltName: Full=UDP-glucose--hexose-1-phosphate uridylyltransferase {ECO:0000255|HAMAP-Rule:MF_00571};
GN   Name=galT {ECO:0000255|HAMAP-Rule:MF_00571}; OrderedLocusNames=Sca_1769;
OS   Staphylococcus carnosus (strain TM300).
OC   Bacteria; Firmicutes; Bacilli; Bacillales; Staphylococcaceae;
OC   Staphylococcus.
OX   NCBI_TaxID=396513;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RA   Krismer B., Goetz F.;
RT   "Organization and nucleotide sequence of the Staphylococcus carnosus
RT   galactose operon.";
RL   Submitted (NOV-1998) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=TM300;
RX   PubMed=19060169; DOI=10.1128/aem.01982-08;
RA   Rosenstein R., Nerz C., Biswas L., Resch A., Raddatz G., Schuster S.C.,
RA   Goetz F.;
RT   "Genome analysis of the meat starter culture bacterium Staphylococcus
RT   carnosus TM300.";
RL   Appl. Environ. Microbiol. 75:811-822(2009).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=alpha-D-galactose 1-phosphate + UDP-alpha-D-glucose = alpha-D-
CC         glucose 1-phosphate + UDP-alpha-D-galactose; Xref=Rhea:RHEA:13989,
CC         ChEBI:CHEBI:58336, ChEBI:CHEBI:58601, ChEBI:CHEBI:58885,
CC         ChEBI:CHEBI:66914; EC=2.7.7.12; Evidence={ECO:0000255|HAMAP-
CC         Rule:MF_00571};
CC   -!- PATHWAY: Carbohydrate metabolism; galactose metabolism.
CC       {ECO:0000255|HAMAP-Rule:MF_00571}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_00571}.
CC   -!- SIMILARITY: Belongs to the galactose-1-phosphate uridylyltransferase
CC       type 2 family. {ECO:0000255|HAMAP-Rule:MF_00571}.
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DR   EMBL; AF109295; AAF25550.1; -; Genomic_DNA.
DR   EMBL; AM295250; CAL28674.1; -; Genomic_DNA.
DR   RefSeq; WP_015901010.1; NC_012121.1.
DR   AlphaFoldDB; Q9RGR9; -.
DR   STRING; 396513.SCA_1769; -.
DR   GeneID; 60544514; -.
DR   KEGG; sca:SCA_1769; -.
DR   eggNOG; COG4468; Bacteria.
DR   HOGENOM; CLU_047799_0_0_9; -.
DR   OMA; IVDWPMS; -.
DR   OrthoDB; 801432at2; -.
DR   BioCyc; SCAR396513:SCA_RS09000-MON; -.
DR   UniPathway; UPA00214; -.
DR   Proteomes; UP000000444; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0008108; F:UDP-glucose:hexose-1-phosphate uridylyltransferase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0006012; P:galactose metabolic process; IEA:UniProtKB-UniRule.
DR   HAMAP; MF_00571; GalP_UDP_trans; 1.
DR   InterPro; IPR000766; GalP_uridyl_Trfase_II.
DR   InterPro; IPR023425; GalP_uridyl_Trfase_II_CS.
DR   InterPro; IPR005850; GalP_Utransf_C.
DR   InterPro; IPR005849; GalP_Utransf_N.
DR   PANTHER; PTHR39191; PTHR39191; 1.
DR   Pfam; PF02744; GalP_UDP_tr_C; 1.
DR   Pfam; PF01087; GalP_UDP_transf; 1.
DR   PIRSF; PIRSF006005; GalT_BS; 1.
DR   TIGRFAMs; TIGR01239; galT_2; 1.
DR   PROSITE; PS01163; GAL_P_UDP_TRANSF_II; 1.
PE   3: Inferred from homology;
KW   Carbohydrate metabolism; Cytoplasm; Galactose metabolism;
KW   Nucleotidyltransferase; Transferase.
FT   CHAIN           1..498
FT                   /note="Galactose-1-phosphate uridylyltransferase"
FT                   /id="PRO_0000169912"
SQ   SEQUENCE   498 AA;  58017 MW;  78A68AD51BC62866 CRC64;
     MNLNRQYVNR FIDDAIQYGD YEREDNYYLQ NLILEITKAE SIDETKNNNG LVNPTSNEIA
     QFWIQQMLNN GLLEDVVYQK EIVETKLLDL ITPKPSTINR EFWKRYESHP EKATGYFYQI
     CKRNHYVKED AIAKNIHYYT ETEYGDLEIT INLSKPEKDA KEIAKAREAK QSSYPANALC
     MENEGFVGSV TQAARRNHRI VRLNLNHQPW GFQFSPYAYF PEHSIVLSEA HEPMKIEKQT
     FSNLLQFVQK FPHYFAGSNA DLPIVGGSIL SHNHYQTGRH TFPMDHAPEM KQFKMEQFPD
     VQAAILKWPM SVIRLKGEDL DEMTEAADHI FETWKSYTDE KLDIRAYSQD GTRHHTVTPI
     ARFNQTTSEY ELDLVLRDNQ TSTQYPDGIF HPHNDVHHIK KENIGLIEVM GTAILPGRLK
     KELLEVERYV LGDINAEPGS HKKWADKMKE KYNFNNENAK NIIHQEVGRI FKRVLEDSGV
     FKQSTEGQKG FEKFIQTL