ID   GALT_STAS1              Reviewed;         496 AA.
AC   Q49ZK0;
DT   15-JAN-2008, integrated into UniProtKB/Swiss-Prot.
DT   13-SEP-2005, sequence version 1.
DT   25-MAY-2022, entry version 89.
DE   RecName: Full=Galactose-1-phosphate uridylyltransferase {ECO:0000255|HAMAP-Rule:MF_00571};
DE            Short=Gal-1-P uridylyltransferase {ECO:0000255|HAMAP-Rule:MF_00571};
DE            EC=2.7.7.12 {ECO:0000255|HAMAP-Rule:MF_00571};
DE   AltName: Full=UDP-glucose--hexose-1-phosphate uridylyltransferase {ECO:0000255|HAMAP-Rule:MF_00571};
GN   Name=galT {ECO:0000255|HAMAP-Rule:MF_00571}; OrderedLocusNames=SSP0631;
OS   Staphylococcus saprophyticus subsp. saprophyticus (strain ATCC 15305 / DSM
OS   20229 / NCIMB 8711 / NCTC 7292 / S-41).
OC   Bacteria; Firmicutes; Bacilli; Bacillales; Staphylococcaceae;
OC   Staphylococcus.
OX   NCBI_TaxID=342451;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 15305 / DSM 20229 / NCIMB 8711 / NCTC 7292 / S-41;
RX   PubMed=16135568; DOI=10.1073/pnas.0502950102;
RA   Kuroda M., Yamashita A., Hirakawa H., Kumano M., Morikawa K., Higashide M.,
RA   Maruyama A., Inose Y., Matoba K., Toh H., Kuhara S., Hattori M., Ohta T.;
RT   "Whole genome sequence of Staphylococcus saprophyticus reveals the
RT   pathogenesis of uncomplicated urinary tract infection.";
RL   Proc. Natl. Acad. Sci. U.S.A. 102:13272-13277(2005).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=alpha-D-galactose 1-phosphate + UDP-alpha-D-glucose = alpha-D-
CC         glucose 1-phosphate + UDP-alpha-D-galactose; Xref=Rhea:RHEA:13989,
CC         ChEBI:CHEBI:58336, ChEBI:CHEBI:58601, ChEBI:CHEBI:58885,
CC         ChEBI:CHEBI:66914; EC=2.7.7.12; Evidence={ECO:0000255|HAMAP-
CC         Rule:MF_00571};
CC   -!- PATHWAY: Carbohydrate metabolism; galactose metabolism.
CC       {ECO:0000255|HAMAP-Rule:MF_00571}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_00571}.
CC   -!- SIMILARITY: Belongs to the galactose-1-phosphate uridylyltransferase
CC       type 2 family. {ECO:0000255|HAMAP-Rule:MF_00571}.
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DR   EMBL; AP008934; BAE17776.1; -; Genomic_DNA.
DR   RefSeq; WP_011302571.1; NZ_MTGA01000036.1.
DR   AlphaFoldDB; Q49ZK0; -.
DR   STRING; 342451.SSP0631; -.
DR   EnsemblBacteria; BAE17776; BAE17776; SSP0631.
DR   KEGG; ssp:SSP0631; -.
DR   PATRIC; fig|342451.11.peg.634; -.
DR   eggNOG; COG4468; Bacteria.
DR   HOGENOM; CLU_047799_0_0_9; -.
DR   OMA; IVDWPMS; -.
DR   OrthoDB; 801432at2; -.
DR   UniPathway; UPA00214; -.
DR   Proteomes; UP000006371; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0008108; F:UDP-glucose:hexose-1-phosphate uridylyltransferase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0006012; P:galactose metabolic process; IEA:UniProtKB-UniRule.
DR   HAMAP; MF_00571; GalP_UDP_trans; 1.
DR   InterPro; IPR000766; GalP_uridyl_Trfase_II.
DR   InterPro; IPR005850; GalP_Utransf_C.
DR   InterPro; IPR005849; GalP_Utransf_N.
DR   PANTHER; PTHR39191; PTHR39191; 1.
DR   Pfam; PF02744; GalP_UDP_tr_C; 1.
DR   Pfam; PF01087; GalP_UDP_transf; 1.
DR   PIRSF; PIRSF006005; GalT_BS; 1.
DR   TIGRFAMs; TIGR01239; galT_2; 1.
PE   3: Inferred from homology;
KW   Carbohydrate metabolism; Cytoplasm; Galactose metabolism;
KW   Nucleotidyltransferase; Reference proteome; Transferase.
FT   CHAIN           1..496
FT                   /note="Galactose-1-phosphate uridylyltransferase"
FT                   /id="PRO_1000025027"
SQ   SEQUENCE   496 AA;  57233 MW;  AF39FBA1ABDB80D3 CRC64;
     MLLNQQLVQQ FVTQAIAFGD YEQEDNIYIQ NQLLRILNAI GIDVDNESPL NQDATANAIA
     QYWIEQAVNE NYLEDALYKK EIVEAQILDL ITPRPSVINR NFVEAYKKSP ETATNYFYEI
     TKRNHYVKED AIANNINYEV ETEYGDIEIT INLSKPEKDA KQIAKAKAEP AKHYPKCALC
     IENEGYQGSV TQAARTNHRI IRLKLDGKSW GFQYSPYAYF PEHSIVLSEH HVPMEINKQT
     FVNLLAFIEQ FPHYFIGSNA DIPLVGGSIL SHNHYQAGKH VFPMDNAAEI ERFTMNQFSS
     VTASTLNWPM SVIRLKSENR DELINAATYV MNTWNQYSDE TIDVRAFSKD GERHHTVTPI
     ARYRQSQYEL DIVLRDNQTS EVFPDGIFHP HEDVQHIKKE NIGLIEVMGT AILPGRLKEE
     LQQVKTYLVG DNQFDLGIHQ QWAENMKRTY DINKQNVDDI VDKEVGYKFK RVLEDAGVFK
     NTDTGRQAFK RFIKHL