ID   GALT_STRMU              Reviewed;         491 AA.
AC   P96994;
DT   01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT   28-NOV-2002, sequence version 2.
DT   03-AUG-2022, entry version 128.
DE   RecName: Full=Galactose-1-phosphate uridylyltransferase;
DE            Short=Gal-1-P uridylyltransferase;
DE            EC=2.7.7.12;
DE   AltName: Full=UDP-glucose--hexose-1-phosphate uridylyltransferase;
GN   Name=galT; OrderedLocusNames=SMU_887;
OS   Streptococcus mutans serotype c (strain ATCC 700610 / UA159).
OC   Bacteria; Firmicutes; Bacilli; Lactobacillales; Streptococcaceae;
OC   Streptococcus.
OX   NCBI_TaxID=210007;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=Ingbritt;
RX   PubMed=8973358; DOI=10.1016/s0378-1119(96)00434-9;
RA   Ajdic D., Sutcliffe I.C., Russell R.R.B., Ferretti J.J.;
RT   "Organization and nucleotide sequence of the Streptococcus mutans galactose
RT   operon.";
RL   Gene 180:137-144(1996).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 700610 / UA159;
RX   PubMed=12397186; DOI=10.1073/pnas.172501299;
RA   Ajdic D.J., McShan W.M., McLaughlin R.E., Savic G., Chang J., Carson M.B.,
RA   Primeaux C., Tian R., Kenton S., Jia H.G., Lin S.P., Qian Y., Li S.,
RA   Zhu H., Najar F.Z., Lai H., White J., Roe B.A., Ferretti J.J.;
RT   "Genome sequence of Streptococcus mutans UA159, a cariogenic dental
RT   pathogen.";
RL   Proc. Natl. Acad. Sci. U.S.A. 99:14434-14439(2002).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=alpha-D-galactose 1-phosphate + UDP-alpha-D-glucose = alpha-D-
CC         glucose 1-phosphate + UDP-alpha-D-galactose; Xref=Rhea:RHEA:13989,
CC         ChEBI:CHEBI:58336, ChEBI:CHEBI:58601, ChEBI:CHEBI:58885,
CC         ChEBI:CHEBI:66914; EC=2.7.7.12;
CC   -!- PATHWAY: Carbohydrate metabolism; galactose metabolism.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the galactose-1-phosphate uridylyltransferase
CC       type 2 family. {ECO:0000305}.
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DR   EMBL; U21942; AAB49737.1; -; Genomic_DNA.
DR   EMBL; AE014133; AAN58601.1; -; Genomic_DNA.
DR   PIR; JC5312; JC5312.
DR   RefSeq; NP_721295.1; NC_004350.2.
DR   RefSeq; WP_002352255.1; NC_004350.2.
DR   AlphaFoldDB; P96994; -.
DR   STRING; 210007.SMU_887; -.
DR   PRIDE; P96994; -.
DR   EnsemblBacteria; AAN58601; AAN58601; SMU_887.
DR   KEGG; smu:SMU_887; -.
DR   PATRIC; fig|210007.7.peg.794; -.
DR   eggNOG; COG4468; Bacteria.
DR   HOGENOM; CLU_047799_0_0_9; -.
DR   OMA; IVDWPMS; -.
DR   PhylomeDB; P96994; -.
DR   UniPathway; UPA00214; -.
DR   Proteomes; UP000002512; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0008108; F:UDP-glucose:hexose-1-phosphate uridylyltransferase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0006012; P:galactose metabolic process; IEA:UniProtKB-UniRule.
DR   HAMAP; MF_00571; GalP_UDP_trans; 1.
DR   InterPro; IPR000766; GalP_uridyl_Trfase_II.
DR   InterPro; IPR023425; GalP_uridyl_Trfase_II_CS.
DR   InterPro; IPR005850; GalP_Utransf_C.
DR   InterPro; IPR005849; GalP_Utransf_N.
DR   PANTHER; PTHR39191; PTHR39191; 1.
DR   Pfam; PF02744; GalP_UDP_tr_C; 1.
DR   Pfam; PF01087; GalP_UDP_transf; 1.
DR   PIRSF; PIRSF006005; GalT_BS; 1.
DR   TIGRFAMs; TIGR01239; galT_2; 1.
DR   PROSITE; PS01163; GAL_P_UDP_TRANSF_II; 1.
PE   3: Inferred from homology;
KW   Carbohydrate metabolism; Cytoplasm; Galactose metabolism;
KW   Nucleotidyltransferase; Reference proteome; Transferase.
FT   CHAIN           1..491
FT                   /note="Galactose-1-phosphate uridylyltransferase"
FT                   /id="PRO_0000169913"
FT   CONFLICT        27
FT                   /note="S -> R (in Ref. 1; AAB49737)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        48
FT                   /note="L -> R (in Ref. 1; AAB49737)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        98
FT                   /note="N -> Y (in Ref. 1; AAB49737)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        117
FT                   /note="N -> D (in Ref. 1; AAB49737)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        286
FT                   /note="R -> H (in Ref. 1; AAB49737)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        383
FT                   /note="I -> V (in Ref. 1; AAB49737)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        452
FT                   /note="I -> V (in Ref. 1; AAB49737)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   491 AA;  55445 MW;  25A5981BB50BF9A0 CRC64;
     MTALLDTFVS KIIENSDYAE LDATYLSNRI LALVGEDNAQ QDTNQSNLIA LKDELVDLAV
     VNGKVGDLAE EKDCLGAELM NFITPIPSQV NKAFWDTNAK SPQKAIKDFY ELSKRNNYIK
     VTAIAKNIAF TTSSVYGDID ITINLSKPEK DPKAIAAAKL AKTSNYPKCQ LCMENEGYQG
     RINYPARANH RIIRMNLGDE KWGFQYSPYA YFNEHCIFLN TEHVPMVISQ NTFRQLLDIV
     DIFPGYFAGS NSDLPIVGGS ILSHNHYQGG RHIFPMEIAE LDSVFRFKDF PDVTAGIVKW
     PMSVIRLRGA NKYSLVELAE IIRLAWRNYS DDTMNILAFT GDTPHHTVTP IARKRDGQFE
     LDIVLRDNHT TAEYPDGVYH PHIDVQHIKK ENIGLIEVMG LAILPPRLKK ELAEVEKYVL
     NQYNEMADYH KDWADAIKAS HPETSSETVS EIVKQAVGRT FVRVLEDAGV YKRNRQGQAA
     FMRFVESIGV K