ID   GALT_STRSL              Reviewed;         493 AA.
AC   Q8VS92;
DT   26-JUL-2002, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2002, sequence version 1.
DT   25-MAY-2022, entry version 72.
DE   RecName: Full=Galactose-1-phosphate uridylyltransferase {ECO:0000255|HAMAP-Rule:MF_00571};
DE            Short=Gal-1-P uridylyltransferase {ECO:0000255|HAMAP-Rule:MF_00571};
DE            EC=2.7.7.12 {ECO:0000255|HAMAP-Rule:MF_00571};
DE   AltName: Full=UDP-glucose--hexose-1-phosphate uridylyltransferase {ECO:0000255|HAMAP-Rule:MF_00571};
GN   Name=galT {ECO:0000255|HAMAP-Rule:MF_00571};
OS   Streptococcus salivarius.
OC   Bacteria; Firmicutes; Bacilli; Lactobacillales; Streptococcaceae;
OC   Streptococcus.
OX   NCBI_TaxID=1304;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=ATCC 25975;
RX   PubMed=11790749; DOI=10.1128/jb.184.3.785-793.2002;
RA   Vaillancourt K., Moineau S., Frenette M., Lessard C., Vadeboncoeur C.;
RT   "Galactose and lactose genes from the galactose-positive bacterium
RT   Streptococcus salivarius and the phylogenetically related galactose-
RT   negative bacterium Streptococcus thermophilus: organization, sequence,
RT   transcription, and activity of the gal gene products.";
RL   J. Bacteriol. 184:785-793(2002).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=alpha-D-galactose 1-phosphate + UDP-alpha-D-glucose = alpha-D-
CC         glucose 1-phosphate + UDP-alpha-D-galactose; Xref=Rhea:RHEA:13989,
CC         ChEBI:CHEBI:58336, ChEBI:CHEBI:58601, ChEBI:CHEBI:58885,
CC         ChEBI:CHEBI:66914; EC=2.7.7.12; Evidence={ECO:0000255|HAMAP-
CC         Rule:MF_00571};
CC   -!- PATHWAY: Carbohydrate metabolism; galactose metabolism.
CC       {ECO:0000255|HAMAP-Rule:MF_00571}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_00571}.
CC   -!- SIMILARITY: Belongs to the galactose-1-phosphate uridylyltransferase
CC       type 2 family. {ECO:0000255|HAMAP-Rule:MF_00571}.
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DR   EMBL; AF389474; AAL67290.1; -; Genomic_DNA.
DR   RefSeq; WP_045772299.1; NZ_WMYH01000005.1.
DR   AlphaFoldDB; Q8VS92; -.
DR   STRING; 1304.HMPREF3219_0201406; -.
DR   PRIDE; Q8VS92; -.
DR   UniPathway; UPA00214; -.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0008108; F:UDP-glucose:hexose-1-phosphate uridylyltransferase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0006012; P:galactose metabolic process; IEA:UniProtKB-UniRule.
DR   HAMAP; MF_00571; GalP_UDP_trans; 1.
DR   InterPro; IPR000766; GalP_uridyl_Trfase_II.
DR   InterPro; IPR023425; GalP_uridyl_Trfase_II_CS.
DR   InterPro; IPR005850; GalP_Utransf_C.
DR   InterPro; IPR005849; GalP_Utransf_N.
DR   PANTHER; PTHR39191; PTHR39191; 1.
DR   Pfam; PF02744; GalP_UDP_tr_C; 1.
DR   Pfam; PF01087; GalP_UDP_transf; 1.
DR   PIRSF; PIRSF006005; GalT_BS; 1.
DR   TIGRFAMs; TIGR01239; galT_2; 1.
DR   PROSITE; PS01163; GAL_P_UDP_TRANSF_II; 1.
PE   3: Inferred from homology;
KW   Carbohydrate metabolism; Cytoplasm; Galactose metabolism;
KW   Nucleotidyltransferase; Transferase.
FT   CHAIN           1..493
FT                   /note="Galactose-1-phosphate uridylyltransferase"
FT                   /id="PRO_0000169918"
SQ   SEQUENCE   493 AA;  55254 MW;  83E851BD094EEEFC CRC64;
     MAENLVNAFV TLVIENSDYE ELDRIYLTNK VFALVGEGVA DVETESSELI DLKDQLLQAG
     VKAGSVGELN EEQDIIGAQL MDLITPSPSA VNRNFWDTYK SNPEQAIADF YVQSKRNDYV
     KVKAIAQNIA YKAPTKYGDL EITINLSKPE KDPKAIAAAK NAVASDYPKC QLCMENEGYL
     GRINHPARSN HRVIRFQMEG NDWGFQYSPY AYFNEHSIFF YGKHEPMHIS PLTFGRLLSI
     VEAFPGYFAG SNADLPIVGG SILTHEHYQG GRHTFPMEVA GIKEKVSFDG YSDVETGIVN
     WPMSVLRLRS EDKERLIALA TKILNCWRGY SDEKAGVLAQ SDGHPHHTIT PIARRKDGKF
     ELDLVLRDNQ TSEEHPDGIY HPHKDVQHIK KENIGLIEVM GLAILPPRLK TELKDVEDYL
     LGQGNQVAPI HQEWADELKA QNPNVTAEEV TEVVRQSVAD IFARVLEDAG VYKTNSEGLD
     QFKAFVDFVN LAD