ID   GALT_STRT2              Reviewed;         493 AA.
AC   Q5M3K1;
DT   30-AUG-2005, integrated into UniProtKB/Swiss-Prot.
DT   30-AUG-2005, sequence version 2.
DT   25-MAY-2022, entry version 87.
DE   RecName: Full=Galactose-1-phosphate uridylyltransferase {ECO:0000255|HAMAP-Rule:MF_00571};
DE            Short=Gal-1-P uridylyltransferase {ECO:0000255|HAMAP-Rule:MF_00571};
DE            EC=2.7.7.12 {ECO:0000255|HAMAP-Rule:MF_00571};
DE   AltName: Full=UDP-glucose--hexose-1-phosphate uridylyltransferase {ECO:0000255|HAMAP-Rule:MF_00571};
GN   Name=galT {ECO:0000255|HAMAP-Rule:MF_00571}; OrderedLocusNames=stu1401;
OS   Streptococcus thermophilus (strain ATCC BAA-250 / LMG 18311).
OC   Bacteria; Firmicutes; Bacilli; Lactobacillales; Streptococcaceae;
OC   Streptococcus.
OX   NCBI_TaxID=264199;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC BAA-250 / LMG 18311;
RX   PubMed=15543133; DOI=10.1038/nbt1034;
RA   Bolotin A., Quinquis B., Renault P., Sorokin A., Ehrlich S.D.,
RA   Kulakauskas S., Lapidus A., Goltsman E., Mazur M., Pusch G.D., Fonstein M.,
RA   Overbeek R., Kyprides N., Purnelle B., Prozzi D., Ngui K., Masuy D.,
RA   Hancy F., Burteau S., Boutry M., Delcour J., Goffeau A., Hols P.;
RT   "Complete sequence and comparative genome analysis of the dairy bacterium
RT   Streptococcus thermophilus.";
RL   Nat. Biotechnol. 22:1554-1558(2004).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=alpha-D-galactose 1-phosphate + UDP-alpha-D-glucose = alpha-D-
CC         glucose 1-phosphate + UDP-alpha-D-galactose; Xref=Rhea:RHEA:13989,
CC         ChEBI:CHEBI:58336, ChEBI:CHEBI:58601, ChEBI:CHEBI:58885,
CC         ChEBI:CHEBI:66914; EC=2.7.7.12; Evidence={ECO:0000255|HAMAP-
CC         Rule:MF_00571};
CC   -!- PATHWAY: Carbohydrate metabolism; galactose metabolism.
CC       {ECO:0000255|HAMAP-Rule:MF_00571}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_00571}.
CC   -!- SIMILARITY: Belongs to the galactose-1-phosphate uridylyltransferase
CC       type 2 family. {ECO:0000255|HAMAP-Rule:MF_00571}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAV61015.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR   EMBL; CP000023; AAV61015.1; ALT_INIT; Genomic_DNA.
DR   RefSeq; WP_041828385.1; NC_006448.1.
DR   AlphaFoldDB; Q5M3K1; -.
DR   STRING; 264199.stu1401; -.
DR   EnsemblBacteria; AAV61015; AAV61015; stu1401.
DR   KEGG; stl:stu1401; -.
DR   eggNOG; COG4468; Bacteria.
DR   HOGENOM; CLU_047799_0_0_9; -.
DR   UniPathway; UPA00214; -.
DR   Proteomes; UP000001170; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0008108; F:UDP-glucose:hexose-1-phosphate uridylyltransferase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0006012; P:galactose metabolic process; IEA:UniProtKB-UniRule.
DR   HAMAP; MF_00571; GalP_UDP_trans; 1.
DR   InterPro; IPR000766; GalP_uridyl_Trfase_II.
DR   InterPro; IPR023425; GalP_uridyl_Trfase_II_CS.
DR   InterPro; IPR005850; GalP_Utransf_C.
DR   InterPro; IPR005849; GalP_Utransf_N.
DR   PANTHER; PTHR39191; PTHR39191; 1.
DR   Pfam; PF02744; GalP_UDP_tr_C; 1.
DR   Pfam; PF01087; GalP_UDP_transf; 1.
DR   PIRSF; PIRSF006005; GalT_BS; 1.
DR   TIGRFAMs; TIGR01239; galT_2; 1.
DR   PROSITE; PS01163; GAL_P_UDP_TRANSF_II; 1.
PE   3: Inferred from homology;
KW   Carbohydrate metabolism; Cytoplasm; Galactose metabolism;
KW   Nucleotidyltransferase; Reference proteome; Transferase.
FT   CHAIN           1..493
FT                   /note="Galactose-1-phosphate uridylyltransferase"
FT                   /id="PRO_0000169921"
SQ   SEQUENCE   493 AA;  55500 MW;  C32D5DF3F2BA6BBC CRC64;
     MAENLVNTFV TQVIENSDYE ELDRIYLTNK VFTLVGEGVA DVETDSSELI DLKDQLLQAG
     VKAGSVGELN EEQDIIGAQL MDLITPRPSV VNRNFWDTYK SNPEQAIADF YAQSKRNDYV
     KVKAIAQNIA YKAPTKYGDL EITINLSKPE KDPKAIAAAK NAVASDYPKC QLCMENEGYL
     GRINHPARSN HRVVRFQMED KEWGFQYSPY AYFNEHSIFF YGKHEPMHIS PLTFGRLLTI
     VEAFPGYFAG SNADLPIVGG SILTHEHYQG GRHTFPMEVA GIKEKVSFDG YSDVEAGIVN
     WPMSVLRLRS EDKERLIALA TKILNCWRGY SDEKAGVLAE SDGQPHHTIT PIARRKDGKF
     ELDLVLRDNQ TSEEYPDGIY HPHKDVQHIK KENIGLIEVM GLAILPPRLK TELKDVEDYL
     LGQGNQVAPI HQEWADELKA QNPNITAEEV TEVVRQSVAD IFARVLEDAG VYKTNNEGLD
     QFKAFVDFVN LAD