ID   GALT_STRTR              Reviewed;         493 AA.
AC   Q9ZB09; Q8VS86;
DT   01-DEC-2000, integrated into UniProtKB/Swiss-Prot.
DT   01-MAY-1999, sequence version 1.
DT   25-MAY-2022, entry version 88.
DE   RecName: Full=Galactose-1-phosphate uridylyltransferase;
DE            Short=Gal-1-P uridylyltransferase;
DE            EC=2.7.7.12;
DE   AltName: Full=UDP-glucose--hexose-1-phosphate uridylyltransferase;
GN   Name=galT;
OS   Streptococcus thermophilus.
OC   Bacteria; Firmicutes; Bacilli; Lactobacillales; Streptococcaceae;
OC   Streptococcus.
OX   NCBI_TaxID=1308;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=CNRZ 302;
RX   PubMed=11157930; DOI=10.1128/jb.183.4.1184-1194.2001;
RA   Vaughan E.E., van den Bogaard P.T.C., Catzeddu P., Kuipers O.P.,
RA   de Vos W.M.;
RT   "Activation of silent gal genes in the lac-gal regulon of Streptococcus
RT   thermophilus.";
RL   J. Bacteriol. 183:1184-1194(2001).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=SMQ-301;
RX   PubMed=11790749; DOI=10.1128/jb.184.3.785-793.2002;
RA   Vaillancourt K., Moineau S., Frenette M., Lessard C., Vadeboncoeur C.;
RT   "Galactose and lactose genes from the galactose-positive bacterium
RT   Streptococcus salivarius and the phylogenetically related galactose-
RT   negative bacterium Streptococcus thermophilus: organization, sequence,
RT   transcription, and activity of the gal gene products.";
RL   J. Bacteriol. 184:785-793(2002).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=alpha-D-galactose 1-phosphate + UDP-alpha-D-glucose = alpha-D-
CC         glucose 1-phosphate + UDP-alpha-D-galactose; Xref=Rhea:RHEA:13989,
CC         ChEBI:CHEBI:58336, ChEBI:CHEBI:58601, ChEBI:CHEBI:58885,
CC         ChEBI:CHEBI:66914; EC=2.7.7.12;
CC   -!- PATHWAY: Carbohydrate metabolism; galactose metabolism.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the galactose-1-phosphate uridylyltransferase
CC       type 2 family. {ECO:0000305}.
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DR   EMBL; U61402; AAD00094.1; -; Genomic_DNA.
DR   EMBL; AF389475; AAL67297.1; -; Genomic_DNA.
DR   RefSeq; WP_041827434.1; NZ_VBTK01000009.1.
DR   AlphaFoldDB; Q9ZB09; -.
DR   STRING; 322159.STER_1370; -.
DR   PRIDE; Q9ZB09; -.
DR   eggNOG; COG4468; Bacteria.
DR   UniPathway; UPA00214; -.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0008108; F:UDP-glucose:hexose-1-phosphate uridylyltransferase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0006012; P:galactose metabolic process; IEA:UniProtKB-UniRule.
DR   HAMAP; MF_00571; GalP_UDP_trans; 1.
DR   InterPro; IPR000766; GalP_uridyl_Trfase_II.
DR   InterPro; IPR023425; GalP_uridyl_Trfase_II_CS.
DR   InterPro; IPR005850; GalP_Utransf_C.
DR   InterPro; IPR005849; GalP_Utransf_N.
DR   PANTHER; PTHR39191; PTHR39191; 1.
DR   Pfam; PF02744; GalP_UDP_tr_C; 1.
DR   Pfam; PF01087; GalP_UDP_transf; 1.
DR   PIRSF; PIRSF006005; GalT_BS; 1.
DR   TIGRFAMs; TIGR01239; galT_2; 1.
DR   PROSITE; PS01163; GAL_P_UDP_TRANSF_II; 1.
PE   3: Inferred from homology;
KW   Carbohydrate metabolism; Cytoplasm; Galactose metabolism;
KW   Nucleotidyltransferase; Transferase.
FT   CHAIN           1..493
FT                   /note="Galactose-1-phosphate uridylyltransferase"
FT                   /id="PRO_0000169919"
FT   VARIANT         42
FT                   /note="I -> V (in strain: SMQ-301)"
FT   VARIANT         70
FT                   /note="K -> N (in strain: SMQ-301)"
FT   VARIANT         107
FT                   /note="I -> T (in strain: SMQ-301)"
FT   VARIANT         243
FT                   /note="V -> A (in strain: SMQ-301)"
FT   VARIANT         480
FT                   /note="A -> D (in strain: SMQ-301)"
SQ   SEQUENCE   493 AA;  55413 MW;  203F5449A40A5FEF CRC64;
     MAENLVNTFV TQVIENSDYE ELDRIYLTNK VFTLVGEGVA DIETDSSELI DLKDQLLQAG
     VKAGSVGELK EEQDIIGAQL MDLITPRPSV VNRNFWDTYK SNPEQAIADF YAQSKRNDYV
     KVKAIAQNIA YKAPTKYGDL EITINLSKPE KDPKAIAAAK NAVASDYPKC QLCMENEGYL
     GRINHPARSN HRVVRFQMED KEWGFQYSPY AYFNEHSIFF YGKHEPMHIS PLTFGRLLTI
     VEVFPGYFAG SNADLPIVGG SILTHEHYQG GRHTFPMEVA GIKEKVSFDG YSDVEAGIVN
     WPMSVLRLRS EDKGRLIALA TKILNCWRGY SDEKAGVLAE SDGQPHHTIT PIARRKDGKF
     ELDLVLRDNQ TSEEYPDGIY HPHKDVQHIK KENIGLIEVM GLAILPPRLK TELKDVEDYL
     LGQGNQVAPI HQEWADELKA QNPNITAEEV TEVVRQSVAD IFARVLEDAG VYKTNSEGLA
     QFKAFVDFVN LAD