ID   GALT_STRZP              Reviewed;         493 AA.
AC   C1CMG3;
DT   28-JUL-2009, integrated into UniProtKB/Swiss-Prot.
DT   26-MAY-2009, sequence version 1.
DT   25-MAY-2022, entry version 61.
DE   RecName: Full=Galactose-1-phosphate uridylyltransferase {ECO:0000255|HAMAP-Rule:MF_00571};
DE            Short=Gal-1-P uridylyltransferase {ECO:0000255|HAMAP-Rule:MF_00571};
DE            EC=2.7.7.12 {ECO:0000255|HAMAP-Rule:MF_00571};
DE   AltName: Full=UDP-glucose--hexose-1-phosphate uridylyltransferase {ECO:0000255|HAMAP-Rule:MF_00571};
GN   Name=galT {ECO:0000255|HAMAP-Rule:MF_00571}; OrderedLocusNames=SPP_1852;
OS   Streptococcus pneumoniae (strain P1031).
OC   Bacteria; Firmicutes; Bacilli; Lactobacillales; Streptococcaceae;
OC   Streptococcus.
OX   NCBI_TaxID=488223;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=P1031;
RX   PubMed=21034474; DOI=10.1186/gb-2010-11-10-r107;
RA   Donati C., Hiller N.L., Tettelin H., Muzzi A., Croucher N.J.,
RA   Angiuoli S.V., Oggioni M., Dunning Hotopp J.C., Hu F.Z., Riley D.R.,
RA   Covacci A., Mitchell T.J., Bentley S.D., Kilian M., Ehrlich G.D.,
RA   Rappuoli R., Moxon E.R., Masignani V.;
RT   "Structure and dynamics of the pan-genome of Streptococcus pneumoniae and
RT   closely related species.";
RL   Genome Biol. 11:R107.1-R107.19(2010).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=alpha-D-galactose 1-phosphate + UDP-alpha-D-glucose = alpha-D-
CC         glucose 1-phosphate + UDP-alpha-D-galactose; Xref=Rhea:RHEA:13989,
CC         ChEBI:CHEBI:58336, ChEBI:CHEBI:58601, ChEBI:CHEBI:58885,
CC         ChEBI:CHEBI:66914; EC=2.7.7.12; Evidence={ECO:0000255|HAMAP-
CC         Rule:MF_00571};
CC   -!- PATHWAY: Carbohydrate metabolism; galactose metabolism.
CC       {ECO:0000255|HAMAP-Rule:MF_00571}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_00571}.
CC   -!- SIMILARITY: Belongs to the galactose-1-phosphate uridylyltransferase
CC       type 2 family. {ECO:0000255|HAMAP-Rule:MF_00571}.
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DR   EMBL; CP000920; ACO20459.1; -; Genomic_DNA.
DR   RefSeq; WP_000177001.1; NC_012467.1.
DR   AlphaFoldDB; C1CMG3; -.
DR   KEGG; spp:SPP_1852; -.
DR   HOGENOM; CLU_047799_0_0_9; -.
DR   OMA; IVDWPMS; -.
DR   UniPathway; UPA00214; -.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0008108; F:UDP-glucose:hexose-1-phosphate uridylyltransferase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0006012; P:galactose metabolic process; IEA:UniProtKB-UniRule.
DR   HAMAP; MF_00571; GalP_UDP_trans; 1.
DR   InterPro; IPR000766; GalP_uridyl_Trfase_II.
DR   InterPro; IPR023425; GalP_uridyl_Trfase_II_CS.
DR   InterPro; IPR005850; GalP_Utransf_C.
DR   InterPro; IPR005849; GalP_Utransf_N.
DR   PANTHER; PTHR39191; PTHR39191; 1.
DR   Pfam; PF02744; GalP_UDP_tr_C; 1.
DR   Pfam; PF01087; GalP_UDP_transf; 1.
DR   PIRSF; PIRSF006005; GalT_BS; 1.
DR   TIGRFAMs; TIGR01239; galT_2; 1.
DR   PROSITE; PS01163; GAL_P_UDP_TRANSF_II; 1.
PE   3: Inferred from homology;
KW   Carbohydrate metabolism; Cytoplasm; Galactose metabolism;
KW   Nucleotidyltransferase; Transferase.
FT   CHAIN           1..493
FT                   /note="Galactose-1-phosphate uridylyltransferase"
FT                   /id="PRO_1000190066"
SQ   SEQUENCE   493 AA;  56234 MW;  B9542FF224262477 CRC64;
     MTLVDKFVTH VISESSFEEM DRIYLTNRVL ARVGEGVLEV ETNLDKLIDL KDQLVEEAVR
     LETIEDSQTA REILGTELMD LVTPCPSQVN RDFWEAYAYS PEQAIEDFYQ LSRKNDYIKL
     KAIAKNIAYR VPSDYGELEI TINLSKPEKD PKEIAVAKLV QASNYPQCQL CLENEGYHGR
     VNHPARSNHR IIRFEMVGQE WGFQYSPYAY FNEHCIFLDG QHRPMAISRQ SFERLLAIVE
     QFPGYFAGSN ADLPIVGGSI LTHDHYQGGR HVFPMELAPL QKTFRFAGFE QVKAGIIKWP
     MSVLRLTSDS KEDLINLADK IFQEWRQYSD SSVQILAETD GTPHHTITPI ARKRDGQFEL
     DLVLRDNQTS AEHPDGIYHP HKDVQHIKKE NIGLIEVMGL AILPPRLKEE VEQVASYLVG
     EAVTVADYHQ EWADQLKSQH PDLTDKEKAL AIVKDSVGAI FVRVLEDAGV YKQTEQGQTA
     FMRFVEQVGI LLD