GALU_HAEIN
ID GALU_HAEIN Reviewed; 295 AA.
AC P44878;
DT 01-NOV-1995, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1995, sequence version 1.
DT 03-AUG-2022, entry version 115.
DE RecName: Full=UTP--glucose-1-phosphate uridylyltransferase;
DE EC=2.7.7.9;
DE AltName: Full=Alpha-D-glucosyl-1-phosphate uridylyltransferase;
DE AltName: Full=UDP-glucose pyrophosphorylase;
DE Short=UDPGP;
DE AltName: Full=Uridine diphosphoglucose pyrophosphorylase;
GN Name=galU; OrderedLocusNames=HI_0812;
OS Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd).
OC Bacteria; Proteobacteria; Gammaproteobacteria; Pasteurellales;
OC Pasteurellaceae; Haemophilus.
OX NCBI_TaxID=71421;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 51907 / DSM 11121 / KW20 / Rd;
RX PubMed=7542800; DOI=10.1126/science.7542800;
RA Fleischmann R.D., Adams M.D., White O., Clayton R.A., Kirkness E.F.,
RA Kerlavage A.R., Bult C.J., Tomb J.-F., Dougherty B.A., Merrick J.M.,
RA McKenney K., Sutton G.G., FitzHugh W., Fields C.A., Gocayne J.D.,
RA Scott J.D., Shirley R., Liu L.-I., Glodek A., Kelley J.M., Weidman J.F.,
RA Phillips C.A., Spriggs T., Hedblom E., Cotton M.D., Utterback T.R.,
RA Hanna M.C., Nguyen D.T., Saudek D.M., Brandon R.C., Fine L.D.,
RA Fritchman J.L., Fuhrmann J.L., Geoghagen N.S.M., Gnehm C.L., McDonald L.A.,
RA Small K.V., Fraser C.M., Smith H.O., Venter J.C.;
RT "Whole-genome random sequencing and assembly of Haemophilus influenzae
RT Rd.";
RL Science 269:496-512(1995).
CC -!- FUNCTION: May play a role in stationary phase survival. {ECO:0000250}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=alpha-D-glucose 1-phosphate + H(+) + UTP = diphosphate + UDP-
CC alpha-D-glucose; Xref=Rhea:RHEA:19889, ChEBI:CHEBI:15378,
CC ChEBI:CHEBI:33019, ChEBI:CHEBI:46398, ChEBI:CHEBI:58601,
CC ChEBI:CHEBI:58885; EC=2.7.7.9;
CC -!- SIMILARITY: Belongs to the UDPGP type 2 family. {ECO:0000305}.
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DR EMBL; L42023; AAC22471.1; -; Genomic_DNA.
DR PIR; G64095; G64095.
DR RefSeq; NP_438972.1; NC_000907.1.
DR RefSeq; WP_005693178.1; NC_000907.1.
DR AlphaFoldDB; P44878; -.
DR SMR; P44878; -.
DR STRING; 71421.HI_0812; -.
DR EnsemblBacteria; AAC22471; AAC22471; HI_0812.
DR KEGG; hin:HI_0812; -.
DR PATRIC; fig|71421.8.peg.853; -.
DR eggNOG; COG1210; Bacteria.
DR HOGENOM; CLU_029499_1_1_6; -.
DR OMA; FSATIWD; -.
DR PhylomeDB; P44878; -.
DR BioCyc; HINF71421:G1GJ1-853-MON; -.
DR Proteomes; UP000000579; Chromosome.
DR GO; GO:0003983; F:UTP:glucose-1-phosphate uridylyltransferase activity; IEA:UniProtKB-EC.
DR GO; GO:0009058; P:biosynthetic process; IEA:InterPro.
DR GO; GO:0006011; P:UDP-glucose metabolic process; IEA:InterPro.
DR CDD; cd02541; UGPase_prokaryotic; 1.
DR Gene3D; 3.90.550.10; -; 1.
DR InterPro; IPR005771; GalU_uridylyltTrfase_bac/arc.
DR InterPro; IPR005835; NTP_transferase_dom.
DR InterPro; IPR029044; Nucleotide-diphossugar_trans.
DR PANTHER; PTHR43197; PTHR43197; 1.
DR Pfam; PF00483; NTP_transferase; 1.
DR SUPFAM; SSF53448; SSF53448; 1.
DR TIGRFAMs; TIGR01099; galU; 1.
PE 3: Inferred from homology;
KW Nucleotidyltransferase; Reference proteome; Transferase.
FT CHAIN 1..295
FT /note="UTP--glucose-1-phosphate uridylyltransferase"
FT /id="PRO_0000201358"
SQ SEQUENCE 295 AA; 32279 MW; FED84173957E571B CRC64;
MKAVIPVAGL GTRMLPATKA IPKEMLTLVD KPLIQYVVNE CVAAGIKEIV LVTHSSKNAI
ENHFDTSFEL ETMLEKRVKR QLLEEVRSIC PKNVTIMHVR QGNAKGLGHA VLCGRPLVGN
ESFAVMLPDV LLAEFSADQK KENLAAMIQR FNETGASQIM VTPVPQENVS SYGVADCGGI
ELNGGESAKI NSIVEKPSIE DAPSNLAVVG RYVFSAAIWD LLEKTPIGVG DEIQLTDAID
MLIEKETVEA FHMTGETFDC GDKIGYMEAF VEYGIRHEKL GKEFKSFIKN LAKTL
