ID   GALU_MYCPN              Reviewed;         291 AA.
AC   P75124;
DT   01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT   01-FEB-1997, sequence version 1.
DT   03-AUG-2022, entry version 100.
DE   RecName: Full=UTP--glucose-1-phosphate uridylyltransferase;
DE            EC=2.7.7.9;
DE   AltName: Full=Alpha-D-glucosyl-1-phosphate uridylyltransferase;
DE   AltName: Full=UDP-glucose pyrophosphorylase;
DE            Short=UDPGP;
DE   AltName: Full=Uridine diphosphoglucose pyrophosphorylase;
GN   Name=galU; Synonyms=gtaB; OrderedLocusNames=MPN_667; ORFNames=MP175;
OS   Mycoplasma pneumoniae (strain ATCC 29342 / M129) (Mycoplasmoides
OS   pneumoniae).
OC   Bacteria; Tenericutes; Mollicutes; Mycoplasmataceae; Mycoplasma.
OX   NCBI_TaxID=272634;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 29342 / M129;
RX   PubMed=8948633; DOI=10.1093/nar/24.22.4420;
RA   Himmelreich R., Hilbert H., Plagens H., Pirkl E., Li B.-C., Herrmann R.;
RT   "Complete sequence analysis of the genome of the bacterium Mycoplasma
RT   pneumoniae.";
RL   Nucleic Acids Res. 24:4420-4449(1996).
CC   -!- FUNCTION: May play a role in stationary phase survival. {ECO:0000250}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=alpha-D-glucose 1-phosphate + H(+) + UTP = diphosphate + UDP-
CC         alpha-D-glucose; Xref=Rhea:RHEA:19889, ChEBI:CHEBI:15378,
CC         ChEBI:CHEBI:33019, ChEBI:CHEBI:46398, ChEBI:CHEBI:58601,
CC         ChEBI:CHEBI:58885; EC=2.7.7.9;
CC   -!- SIMILARITY: Belongs to the UDPGP type 2 family. {ECO:0000305}.
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DR   EMBL; U00089; AAB95823.1; -; Genomic_DNA.
DR   PIR; S73501; S73501.
DR   RefSeq; NP_110356.1; NC_000912.1.
DR   RefSeq; WP_010875024.1; NC_000912.1.
DR   AlphaFoldDB; P75124; -.
DR   SMR; P75124; -.
DR   STRING; 272634.MPN_667; -.
DR   EnsemblBacteria; AAB95823; AAB95823; MPN_667.
DR   KEGG; mpn:MPN_667; -.
DR   PATRIC; fig|272634.6.peg.732; -.
DR   HOGENOM; CLU_029499_1_0_14; -.
DR   OMA; MHYVRQG; -.
DR   BioCyc; MetaCyc:MON-642; -.
DR   BioCyc; MPNE272634:G1GJ3-1069-MON; -.
DR   Proteomes; UP000000808; Chromosome.
DR   GO; GO:0003983; F:UTP:glucose-1-phosphate uridylyltransferase activity; IEA:UniProtKB-EC.
DR   GO; GO:0009058; P:biosynthetic process; IEA:InterPro.
DR   GO; GO:0006011; P:UDP-glucose metabolic process; IEA:InterPro.
DR   CDD; cd02541; UGPase_prokaryotic; 1.
DR   Gene3D; 3.90.550.10; -; 1.
DR   InterPro; IPR005771; GalU_uridylyltTrfase_bac/arc.
DR   InterPro; IPR005835; NTP_transferase_dom.
DR   InterPro; IPR029044; Nucleotide-diphossugar_trans.
DR   PANTHER; PTHR43197; PTHR43197; 1.
DR   Pfam; PF00483; NTP_transferase; 1.
DR   SUPFAM; SSF53448; SSF53448; 1.
DR   TIGRFAMs; TIGR01099; galU; 1.
PE   3: Inferred from homology;
KW   Nucleotidyltransferase; Reference proteome; Transferase.
FT   CHAIN           1..291
FT                   /note="UTP--glucose-1-phosphate uridylyltransferase"
FT                   /id="PRO_0000201360"
SQ   SEQUENCE   291 AA;  32168 MW;  B422FF63FD64F1CF CRC64;
     MPKIRKAVIP AAGLGTRLLP ATKAIPKEML PLVNKPTIQY IVEEAVASGI KEILVIVSSK
     KEAIIDHFDY DFILENALLQ KHKDQEHQEI KDIANLAHIY FVRQKHQHGL GDAILHAKSF
     VGNEDFAVLL GDDVVFGEQP ALAQCIQAYE QTDCQVIGVQ EVPHDQVNKY GIVTPEANWQ
     KQALVKILGM VEKPAVNEAK SNLAILSRYI LKPSIFTALK QVPFGVGGEL QLTDGLNYCL
     QQGEPFFAKH FGGTRFDVGT KNGFIKANLY TALKTDAITK DEVLAILKEF A