ID   GAL_GALME               Reviewed;          76 AA.
AC   Q8MVY9;
DT   23-FEB-2022, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-2002, sequence version 1.
DT   03-AUG-2022, entry version 27.
DE   RecName: Full=Gallerimycin {ECO:0000303|PubMed:12811766};
DE   AltName: Full=Defensin-like peptide gallerimycin {ECO:0000303|PubMed:12811766};
DE   Flags: Precursor;
GN   Name=LOC113523440 {ECO:0000312|RefSeq:XP_026765221.1};
OS   Galleria mellonella (Greater wax moth).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Lepidoptera; Glossata; Ditrysia; Pyraloidea;
OC   Pyralidae; Galleriinae; Galleria.
OX   NCBI_TaxID=7137 {ECO:0000312|Proteomes:UP000504614};
RN   [1] {ECO:0000312|EMBL:AAM46728.1}
RP   NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, AND INDUCTION BY LPS.
RX   PubMed=12811766; DOI=10.1002/arch.10091;
RA   Schuhmann B., Seitz V., Vilcinskas A., Podsiadlowski L.;
RT   "Cloning and expression of gallerimycin, an antifungal peptide expressed in
RT   immune response of greater wax moth larvae, Galleria mellonella.";
RL   Arch. Insect Biochem. Physiol. 53:125-133(2003).
RN   [2] {ECO:0000305}
RP   DEVELOPMENTAL STAGE, AND INDUCTION BY A.NIGER ALPHA-1,3-GLUCAN.
RX   PubMed=34443685; DOI=10.3390/molecules26165097;
RA   Staczek S., Zdybicka-Barabas A., Wojda I., Wiater A., Mak P., Suder P.,
RA   Skrzypiec K., Cytrynska M.;
RT   "Fungal alpha-1,3-Glucan as a New Pathogen-Associated Molecular Pattern in
RT   the Insect Model Host Galleria mellonella.";
RL   Molecules 26:5097-5097(2021).
CC   -!- FUNCTION: Has antifungal activity against the entomopathogenic fungus
CC       M.nisopliae, but does not display any antifungal activity against
CC       S.cerevisiae nor any antimicrobial acivity against M.luteus,
CC       B.subtilis, and E.coli. {ECO:0000269|PubMed:12811766}.
CC   -!- DEVELOPMENTAL STAGE: Expressed in fat body of last instar larvae.
CC       {ECO:0000269|PubMed:34443685}.
CC   -!- INDUCTION: Induced by lipopolysaccharides (LSP) (PubMed:12811766).
CC       Induced by A.niger alpha-1,3-glucan (PubMed:34443685).
CC       {ECO:0000269|PubMed:12811766, ECO:0000269|PubMed:34443685}.
CC   -!- SIMILARITY: Belongs to the invertebrate defensin family. {ECO:0000305}.
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DR   EMBL; AF453824; AAM46728.1; -; mRNA.
DR   RefSeq; XP_026765221.1; XM_026909420.2.
DR   SMR; Q8MVY9; -.
DR   Proteomes; UP000504614; Unplaced.
DR   GO; GO:0006952; P:defense response; IEA:UniProtKB-KW.
PE   2: Evidence at transcript level;
KW   Antimicrobial; Defensin; Reference proteome; Signal.
FT   SIGNAL          1..19
FT                   /evidence="ECO:0000255"
FT   CHAIN           20..76
FT                   /note="Gallerimycin"
FT                   /evidence="ECO:0000255"
FT                   /id="PRO_5029322080"
SQ   SEQUENCE   76 AA;  8400 MW;  652EDA004A279410 CRC64;
     MKIAFIVAIS LAFLAVTSCI EFEKSTESHD IQKRGVTITV KPPFPGCVFY ECIANCRSRG
     YKNGGYCTIN GCQCLR