ID   GANC_MACFA              Reviewed;         769 AA.
AC   Q9BE70;
DT   07-JUN-2004, integrated into UniProtKB/Swiss-Prot.
DT   07-JUN-2004, sequence version 2.
DT   25-MAY-2022, entry version 66.
DE   RecName: Full=Neutral alpha-glucosidase C;
DE            EC=3.2.1.20;
DE   Flags: Fragment;
GN   Name=GANC; ORFNames=QflA-12512;
OS   Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC   Cercopithecidae; Cercopithecinae; Macaca.
OX   NCBI_TaxID=9541;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Frontal cortex;
RX   PubMed=11806829; DOI=10.1186/gb-2001-3-1-research0006;
RA   Osada N., Hida M., Kusuda J., Tanuma R., Hirata M., Hirai M., Terao K.,
RA   Suzuki Y., Sugano S., Hashimoto K.;
RT   "Prediction of unidentified human genes on the basis of sequence similarity
RT   to novel cDNAs from cynomolgus monkey brain.";
RL   Genome Biol. 3:RESEARCH0006.1-RESEARCH0006.5(2002).
CC   -!- FUNCTION: Has alpha-glucosidase activity. {ECO:0000250}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=Hydrolysis of terminal, non-reducing (1->4)-linked alpha-D-
CC         glucose residues with release of alpha-D-glucose.; EC=3.2.1.20;
CC   -!- SIMILARITY: Belongs to the glycosyl hydrolase 31 family. {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=BAB39324.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR   EMBL; AB056800; BAB39324.1; ALT_INIT; mRNA.
DR   AlphaFoldDB; Q9BE70; -.
DR   SMR; Q9BE70; -.
DR   STRING; 9541.XP_005559352.1; -.
DR   CAZy; GH31; Glycoside Hydrolase Family 31.
DR   eggNOG; KOG1066; Eukaryota.
DR   Proteomes; UP000233100; Unplaced.
DR   GO; GO:0030246; F:carbohydrate binding; IEA:InterPro.
DR   GO; GO:0032450; F:maltose alpha-glucosidase activity; IEA:UniProtKB-EC.
DR   Gene3D; 2.60.40.1180; -; 2.
DR   InterPro; IPR011013; Gal_mutarotase_sf_dom.
DR   InterPro; IPR000322; Glyco_hydro_31.
DR   InterPro; IPR030458; Glyco_hydro_31_AS.
DR   InterPro; IPR025887; Glyco_hydro_31_N_dom.
DR   InterPro; IPR013780; Glyco_hydro_b.
DR   InterPro; IPR017853; Glycoside_hydrolase_SF.
DR   Pfam; PF13802; Gal_mutarotas_2; 1.
DR   Pfam; PF01055; Glyco_hydro_31; 1.
DR   SUPFAM; SSF51445; SSF51445; 1.
DR   SUPFAM; SSF74650; SSF74650; 1.
DR   PROSITE; PS00129; GLYCOSYL_HYDROL_F31_1; 1.
PE   2: Evidence at transcript level;
KW   Glycosidase; Hydrolase; Reference proteome.
FT   CHAIN           <1..769
FT                   /note="Neutral alpha-glucosidase C"
FT                   /id="PRO_0000185365"
FT   ACT_SITE        366
FT                   /note="Nucleophile"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU10066"
FT   ACT_SITE        369
FT                   /evidence="ECO:0000250"
FT   ACT_SITE        442
FT                   /note="Proton donor"
FT                   /evidence="ECO:0000250"
FT   NON_TER         1
SQ   SEQUENCE   769 AA;  88087 MW;  5F930351BC58C45A CRC64;
     EEEVVISINS LGQLYFEHLQ ILHKQRAAKE NEEEASVDTS QENQEDLGLW EEKFGKFVDI
     KANGPSSIGL DFSLHGFEHL YGIPQHAESH QLKNTGDEDA YRLYNLDVYG YQIYDKMGIY
     GSVPYLLAHK LGRTIGIFWL NASETLVEIN TEPAVEYTLS QMGPVAAKQK VRSRTHVHWM
     SESGIIDVFL LTGPTPSDVF KQYSHLTGTQ AMPPLFSLGY HQCRWNYEDE QDVKAVDAGF
     DEHDIPYDAM WLDIEHTEGK RYFTWDKKRF PNPERMQELL RSKKRKLVVI SDPHIKIDPD
     YSVYVKAKDQ GFFVKNQEGE DFEGVCWPGL SSYLDFTNPK VREWYSSLFA FPVYQGSTDI
     LFLWNDMNEP SVFRRPEQTM QKNAIHHGNW EHRELHNIYG FYHQMATAEG LIQRSGGKER
     PFVLTRSFFA GSQKYGAVWT GDNTAEWSYL KISIPMLLTL SITGISFCGA DIGGFIGNPE
     TELLVRWYQA GAYQPFFRGH ATMNAKRREP WLFGKEHTRL IREAIRERYG LLPYWYSLFY
     HAHVASQPVM RPLWVEFPDE LKTFDMEDEY MLGSALLVHP VTEPKATTVD VFLPGSNEVW
     YDYKTFAHWE GGCTVKIPVA LDTIPVFQRG GSVVPIKTTV GKSTGWMTES SYGLRVALST
     KGSSVGELYL DDGHSFQYLH QKQFLHRKFS FCSSVLINSS ADQRGHYPSK CVVEQILVLG
     LRKEPSFVTT HSSDGKDQPV AFTYCAKTSS LSLEKLSLNI ATDWEVRII