ID   GAP1_CAEEL              Reviewed;         629 AA.
AC   Q22720;
DT   19-JUL-2003, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1996, sequence version 1.
DT   03-AUG-2022, entry version 138.
DE   RecName: Full=Ras GTPase-activating protein gap-1;
DE            Short=GTPase-activating protein 1;
GN   Name=gap-1; ORFNames=T24C12.2;
OS   Caenorhabditis elegans.
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC   Caenorhabditis.
OX   NCBI_TaxID=6239;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA], AND FUNCTION.
RC   STRAIN=Bristol N2;
RX   PubMed=9334333; DOI=10.1101/gad.11.20.2715;
RA   Hajnal A., Whitfield C.W., Kim S.K.;
RT   "Inhibition of Caenorhabditis elegans vulval induction by gap-1 and by let-
RT   23 receptor tyrosine kinase.";
RL   Genes Dev. 11:2715-2728(1997).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Bristol N2;
RX   PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG   The C. elegans sequencing consortium;
RT   "Genome sequence of the nematode C. elegans: a platform for investigating
RT   biology.";
RL   Science 282:2012-2018(1998).
CC   -!- FUNCTION: GTPase-activating protein, which inhibits the vulval
CC       induction by acting as a negative regulator for the member of the Ras
CC       family let-60. Probably decreases the signaling activity of Ras by
CC       stimulating its intrinsic GTPase activity, thereby lowering the levels
CC       of GTP-bound, active Ras. {ECO:0000269|PubMed:9334333}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}.
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DR   EMBL; AF118123; AAD13781.1; -; mRNA.
DR   EMBL; FO081420; CCD71505.1; -; Genomic_DNA.
DR   PIR; T34370; T34370.
DR   RefSeq; NP_508404.1; NM_076003.1.
DR   AlphaFoldDB; Q22720; -.
DR   STRING; 6239.T24C12.2; -.
DR   PaxDb; Q22720; -.
DR   PeptideAtlas; Q22720; -.
DR   EnsemblMetazoa; T24C12.2.1; T24C12.2.1; WBGene00001515.
DR   GeneID; 180530; -.
DR   KEGG; cel:CELE_T24C12.2; -.
DR   UCSC; T24C12.2; c. elegans.
DR   CTD; 180530; -.
DR   WormBase; T24C12.2; CE05002; WBGene00001515; gap-1.
DR   eggNOG; KOG2059; Eukaryota.
DR   GeneTree; ENSGT00940000167058; -.
DR   HOGENOM; CLU_483347_0_0_1; -.
DR   InParanoid; Q22720; -.
DR   OMA; WLEMPCA; -.
DR   OrthoDB; 145372at2759; -.
DR   PhylomeDB; Q22720; -.
DR   SignaLink; Q22720; -.
DR   PRO; PR:Q22720; -.
DR   Proteomes; UP000001940; Chromosome X.
DR   Bgee; WBGene00001515; Expressed in pharyngeal muscle cell (C elegans) and 3 other tissues.
DR   GO; GO:0005737; C:cytoplasm; NAS:UniProtKB.
DR   GO; GO:0005096; F:GTPase activator activity; NAS:UniProtKB.
DR   GO; GO:0008306; P:associative learning; IMP:WormBase.
DR   GO; GO:0007635; P:chemosensory behavior; IGI:WormBase.
DR   GO; GO:0007616; P:long-term memory; IGI:WormBase.
DR   GO; GO:0046580; P:negative regulation of Ras protein signal transduction; IEP:UniProtKB.
DR   GO; GO:0043087; P:regulation of GTPase activity; IEA:InterPro.
DR   GO; GO:0007614; P:short-term memory; IGI:WormBase.
DR   GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR   Gene3D; 1.10.506.10; -; 1.
DR   Gene3D; 2.30.29.30; -; 1.
DR   InterPro; IPR011993; PH-like_dom_sf.
DR   InterPro; IPR001849; PH_domain.
DR   InterPro; IPR039360; Ras_GTPase.
DR   InterPro; IPR023152; RasGAP_CS.
DR   InterPro; IPR001936; RasGAP_dom.
DR   InterPro; IPR008936; Rho_GTPase_activation_prot.
DR   PANTHER; PTHR10194; PTHR10194; 1.
DR   Pfam; PF00616; RasGAP; 1.
DR   SMART; SM00233; PH; 1.
DR   SMART; SM00323; RasGAP; 1.
DR   SUPFAM; SSF48350; SSF48350; 1.
DR   PROSITE; PS50003; PH_DOMAIN; 1.
DR   PROSITE; PS00509; RAS_GTPASE_ACTIV_1; 1.
DR   PROSITE; PS50018; RAS_GTPASE_ACTIV_2; 1.
PE   2: Evidence at transcript level;
KW   Cytoplasm; GTPase activation; Reference proteome.
FT   CHAIN           1..629
FT                   /note="Ras GTPase-activating protein gap-1"
FT                   /id="PRO_0000056663"
FT   DOMAIN          167..360
FT                   /note="Ras-GAP"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00167"
FT   DOMAIN          411..507
FT                   /note="PH"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00145"
SQ   SEQUENCE   629 AA;  71316 MW;  E1EFF7868C6A2F98 CRC64;
     MVLSCRVVDC GGLKLKENQT LLLLVSTIHN SSEVGKLSID AEEKRSKEWL EMPCAEGMLS
     LKLTLWQDLL KGINSVFHGQ VRVDVDENWK SGPAKWFYLR SKANEDGEGG EDGGDIGDAT
     VKVTYQIDHI LRMQVYKPLL DLLFLAGDVQ PLTASLVAVI EALPKVELGP VSRSLVELMA
     QSDRIRPVLS SLYVNSILKC QDENTLFRGQ SLSGKMLFEI LTTYGKMYLI TTLKPVVDKI
     YKERKNCEVD PARVAVGASL EKNRNNLLVY FQMLFERVTT SSTNCPHLIK QLLYDLRNVV
     GTHSSRSGVQ RLAVSSFVIM RFFAAAILNP KAFEIRKDQP DLRVSRTLLL LSKLLQRLSN
     CSVSEGPLSS KEIWLNGVFE TVTSEQHKSV MASFLDNISL VGDRSEPQKC TVFKFGNLQQ
     VDRSRLAWKK VLHYKKRYVQ LTNTHLIWQK DVQCAPKGTV PLSDIKFVNV DNKNIITIVC
     ETMQLQFEAP GGVEATDWLN AIERQRNRAA HEIAETPGEH FFVDAERHVD KIHTLLYKYR
     ETMIEWRDQL QSNVELDEKT APELLKASYV VEEERQSHKD SLIATLCSTI DVTDAIQLAH
     TEYEKENKVS RRIDAIITAK KRQKSFSVK