GAP2_CAEEL
ID GAP2_CAEEL Reviewed; 1207 AA.
AC Q8MLZ5; A6ZJ45; K8ERX6; K8ERY0; K8ESF6; K8ESL7; K8F7Z7; K8FE04; M1ZJ21;
AC M1ZMJ4; O44239; O44240; O44241; O44242; O44243; O44244; O44245; Q3S1K5;
AC Q9TVD9; Q9TVE0; Q9TVE1; Q9TVE2; Q9TVE3; Q9TVE4; Q9U991; Q9UAH9; Q9UAI0;
DT 19-JUL-2003, integrated into UniProtKB/Swiss-Prot.
DT 19-JUL-2003, sequence version 2.
DT 03-AUG-2022, entry version 138.
DE RecName: Full=Ras GTPase-activating protein gap-2;
DE Short=GTPase-activating protein 2;
GN Name=gap-2; ORFNames=ZK899.8;
OS Caenorhabditis elegans.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC Caenorhabditis.
OX NCBI_TaxID=6239;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM D), PARTIAL NUCLEOTIDE SEQUENCE [MRNA]
RP (ISOFORMS A; B; C; E; F AND G), TISSUE SPECIFICITY, AND FUNCTION.
RC STRAIN=Bristol N2;
RX PubMed=9619631; DOI=10.1046/j.1365-2443.1998.00179.x;
RA Hayashizaki S., Iino Y., Yamamoto M.;
RT "Characterization of the C. elegans gap-2 gene encoding a novel Ras-GTPase
RT activating protein and its possible role in larval development.";
RL Genes Cells 3:189-202(1998).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Bristol N2;
RX PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG The C. elegans sequencing consortium;
RT "Genome sequence of the nematode C. elegans: a platform for investigating
RT biology.";
RL Science 282:2012-2018(1998).
CC -!- FUNCTION: GTPase-activating protein, which acts as a negative regulator
CC for the member of the Ras family let-60. Probably decreases the
CC signaling activity of Ras by stimulating its intrinsic GTPase activity,
CC thereby lowering the levels of GTP-bound, active Ras. The different
CC isoforms may play a distinct role in specific tissues.
CC {ECO:0000269|PubMed:9619631}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=12;
CC Name=a {ECO:0000312|WormBase:ZK899.8a}; Synonyms=GAP-2-1
CC {ECO:0000303|PubMed:9619631};
CC IsoId=Q8MLZ5-1; Sequence=Displayed;
CC Name=b {ECO:0000312|WormBase:ZK899.8b}; Synonyms=GAP-2-2
CC {ECO:0000303|PubMed:9619631};
CC IsoId=Q8MLZ5-2; Sequence=VSP_007788, VSP_007789;
CC Name=c {ECO:0000312|WormBase:ZK899.8c}; Synonyms=GAP-2-3
CC {ECO:0000303|PubMed:9619631};
CC IsoId=Q8MLZ5-3; Sequence=VSP_007790, VSP_007789;
CC Name=d {ECO:0000312|WormBase:ZK899.8d}; Synonyms=GAP-2-4
CC {ECO:0000303|PubMed:9619631};
CC IsoId=Q8MLZ5-4; Sequence=VSP_007791, VSP_007792, VSP_007789;
CC Name=e {ECO:0000312|WormBase:ZK899.8e}; Synonyms=GAP-2-5
CC {ECO:0000303|PubMed:9619631};
CC IsoId=Q8MLZ5-5; Sequence=VSP_007793, VSP_007794;
CC Name=f {ECO:0000312|WormBase:ZK899.8f}; Synonyms=GAP-2-7
CC {ECO:0000303|PubMed:9619631};
CC IsoId=Q8MLZ5-6; Sequence=VSP_007795, VSP_007796;
CC Name=g {ECO:0000312|WormBase:ZK899.8e}; Synonyms=GAP-2-9
CC {ECO:0000303|PubMed:9619631};
CC IsoId=Q8MLZ5-7; Sequence=VSP_007797, VSP_007798;
CC Name=h;
CC IsoId=Q8MLZ5-8; Sequence=VSP_007799, VSP_007800, VSP_007789;
CC Name=i {ECO:0000312|WormBase:ZK899.8i};
CC IsoId=Q8MLZ5-9; Sequence=VSP_058284;
CC Name=j {ECO:0000312|WormBase:ZK899.8j};
CC IsoId=Q8MLZ5-10; Sequence=VSP_058283;
CC Name=k {ECO:0000312|WormBase:ZK899.8k};
CC IsoId=Q8MLZ5-11; Sequence=VSP_058286;
CC Name=l {ECO:0000312|WormBase:ZK899.8l};
CC IsoId=Q8MLZ5-12; Sequence=VSP_058285;
CC -!- TISSUE SPECIFICITY: Mainly expressed in gonads and vulval cells.
CC Isoform c in expressed in pharyngeal epithelial cells and several
CC rectal/blast cells in the tail region. Isoform f is weakly expressed in
CC four cells symmetrically located in the vulval region. Isoform g is
CC strongly expressed in the pharyngeal muscle cells m6 in addition to
CC several cells in the tail region. {ECO:0000269|PubMed:9619631}.
CC -!- SEQUENCE CAUTION:
CC Sequence=BAA24960.1; Type=Frameshift; Evidence={ECO:0000305};
CC Sequence=BAA24962.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};
CC Sequence=BAA24964.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};
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DR EMBL; AB011277; BAA24957.1; -; mRNA.
DR EMBL; AB011278; BAA24958.1; -; mRNA.
DR EMBL; AB011279; BAA24959.1; -; mRNA.
DR EMBL; AB011280; BAA24960.1; ALT_FRAME; mRNA.
DR EMBL; AB011281; BAA24961.1; -; mRNA.
DR EMBL; AB011282; BAA24962.1; ALT_INIT; mRNA.
DR EMBL; AB011283; BAA24963.1; -; mRNA.
DR EMBL; AB011284; BAA24964.1; ALT_INIT; mRNA.
DR EMBL; AB011285; BAA24965.1; -; mRNA.
DR EMBL; Z37140; CAA85503.1; -; Genomic_DNA.
DR EMBL; Z37979; CAA85503.1; JOINED; Genomic_DNA.
DR EMBL; Z46266; CAA85503.1; JOINED; Genomic_DNA.
DR EMBL; Z46266; CAA86414.2; -; Genomic_DNA.
DR EMBL; BX284606; CAJ30221.1; -; Genomic_DNA.
DR EMBL; BX284606; CAO78710.1; -; Genomic_DNA.
DR EMBL; BX284606; CCO25886.1; -; Genomic_DNA.
DR EMBL; BX284606; CCO25887.1; -; Genomic_DNA.
DR EMBL; BX284606; CCO25888.1; -; Genomic_DNA.
DR EMBL; BX284606; CCO25889.1; -; Genomic_DNA.
DR EMBL; BX284606; CCO25890.1; -; Genomic_DNA.
DR EMBL; BX284606; CCO25891.1; -; Genomic_DNA.
DR EMBL; BX284606; CCU83306.1; -; Genomic_DNA.
DR EMBL; BX284606; CCU83365.1; -; Genomic_DNA.
DR PIR; D89610; D89610.
DR PIR; T19040; T19040.
DR PIR; T19041; T19041.
DR PIR; T19042; T19042.
DR PIR; T19043; T19043.
DR PIR; T19045; T19045.
DR PIR; T19046; T19046.
DR PIR; T37279; T37279.
DR PIR; T37300; T37300.
DR PIR; T37302; T37302.
DR PIR; T37304; T37304.
DR RefSeq; NP_001033580.1; NM_001038491.3.
DR RefSeq; NP_001123198.1; NM_001129726.1. [Q8MLZ5-10]
DR RefSeq; NP_001294843.1; NM_001307914.1. [Q8MLZ5-12]
DR RefSeq; NP_001294845.1; NM_001307916.1. [Q8MLZ5-11]
DR RefSeq; NP_509594.3; NM_077193.4. [Q8MLZ5-1]
DR RefSeq; NP_509595.1; NM_077194.3. [Q8MLZ5-2]
DR RefSeq; NP_509596.1; NM_077195.4. [Q8MLZ5-3]
DR RefSeq; NP_509597.1; NM_077196.3. [Q8MLZ5-4]
DR RefSeq; NP_509598.1; NM_077197.3. [Q8MLZ5-5]
DR RefSeq; NP_509599.1; NM_077198.3. [Q8MLZ5-6]
DR RefSeq; NP_741873.1; NM_171753.3. [Q8MLZ5-8]
DR RefSeq; NP_741874.1; NM_171754.3. [Q8MLZ5-7]
DR AlphaFoldDB; Q8MLZ5; -.
DR SMR; Q8MLZ5; -.
DR BioGRID; 46088; 3.
DR IntAct; Q8MLZ5; 1.
DR STRING; 6239.ZK899.8c; -.
DR PaxDb; Q8MLZ5; -.
DR PeptideAtlas; Q8MLZ5; -.
DR EnsemblMetazoa; ZK899.8a.1; ZK899.8a.1; WBGene00001516. [Q8MLZ5-1]
DR EnsemblMetazoa; ZK899.8b.1; ZK899.8b.1; WBGene00001516. [Q8MLZ5-2]
DR EnsemblMetazoa; ZK899.8c.1; ZK899.8c.1; WBGene00001516. [Q8MLZ5-3]
DR EnsemblMetazoa; ZK899.8d.1; ZK899.8d.1; WBGene00001516. [Q8MLZ5-4]
DR EnsemblMetazoa; ZK899.8e.1; ZK899.8e.1; WBGene00001516. [Q8MLZ5-5]
DR EnsemblMetazoa; ZK899.8f.1; ZK899.8f.1; WBGene00001516. [Q8MLZ5-6]
DR EnsemblMetazoa; ZK899.8g.1; ZK899.8g.1; WBGene00001516. [Q8MLZ5-7]
DR EnsemblMetazoa; ZK899.8h.1; ZK899.8h.1; WBGene00001516. [Q8MLZ5-8]
DR EnsemblMetazoa; ZK899.8i.1; ZK899.8i.1; WBGene00001516. [Q8MLZ5-9]
DR EnsemblMetazoa; ZK899.8i.2; ZK899.8i.2; WBGene00001516. [Q8MLZ5-9]
DR EnsemblMetazoa; ZK899.8i.3; ZK899.8i.3; WBGene00001516. [Q8MLZ5-9]
DR EnsemblMetazoa; ZK899.8i.4; ZK899.8i.4; WBGene00001516. [Q8MLZ5-9]
DR EnsemblMetazoa; ZK899.8i.5; ZK899.8i.5; WBGene00001516. [Q8MLZ5-9]
DR EnsemblMetazoa; ZK899.8j.1; ZK899.8j.1; WBGene00001516. [Q8MLZ5-10]
DR EnsemblMetazoa; ZK899.8k.1; ZK899.8k.1; WBGene00001516. [Q8MLZ5-11]
DR EnsemblMetazoa; ZK899.8l.1; ZK899.8l.1; WBGene00001516. [Q8MLZ5-12]
DR GeneID; 181172; -.
DR KEGG; cel:CELE_ZK899.8; -.
DR UCSC; ZK899.8a; c. elegans.
DR CTD; 181172; -.
DR WormBase; ZK899.8a; CE23470; WBGene00001516; gap-2. [Q8MLZ5-1]
DR WormBase; ZK899.8b; CE23471; WBGene00001516; gap-2. [Q8MLZ5-2]
DR WormBase; ZK899.8c; CE23472; WBGene00001516; gap-2. [Q8MLZ5-3]
DR WormBase; ZK899.8d; CE23473; WBGene00001516; gap-2. [Q8MLZ5-4]
DR WormBase; ZK899.8e; CE23474; WBGene00001516; gap-2. [Q8MLZ5-5]
DR WormBase; ZK899.8f; CE23475; WBGene00001516; gap-2. [Q8MLZ5-6]
DR WormBase; ZK899.8g; CE28277; WBGene00001516; gap-2. [Q8MLZ5-7]
DR WormBase; ZK899.8h; CE31677; WBGene00001516; gap-2. [Q8MLZ5-8]
DR WormBase; ZK899.8i; CE39119; WBGene00001516; gap-2. [Q8MLZ5-9]
DR WormBase; ZK899.8j; CE23476; WBGene00001516; gap-2. [Q8MLZ5-10]
DR WormBase; ZK899.8k; CE48260; WBGene00001516; gap-2. [Q8MLZ5-11]
DR WormBase; ZK899.8l; CE48295; WBGene00001516; gap-2. [Q8MLZ5-12]
DR eggNOG; KOG3508; Eukaryota.
DR GeneTree; ENSGT00940000172132; -.
DR InParanoid; Q8MLZ5; -.
DR OMA; ITGPHTI; -.
DR OrthoDB; 733775at2759; -.
DR PhylomeDB; Q8MLZ5; -.
DR SignaLink; Q8MLZ5; -.
DR PRO; PR:Q8MLZ5; -.
DR Proteomes; UP000001940; Chromosome X.
DR Bgee; WBGene00001516; Expressed in pharyngeal muscle cell (C elegans) and 7 other tissues.
DR GO; GO:0005737; C:cytoplasm; NAS:UniProtKB.
DR GO; GO:0005096; F:GTPase activator activity; NAS:UniProtKB.
DR GO; GO:0008306; P:associative learning; IGI:WormBase.
DR GO; GO:0007616; P:long-term memory; IMP:WormBase.
DR GO; GO:0046580; P:negative regulation of Ras protein signal transduction; IEP:UniProtKB.
DR GO; GO:0043087; P:regulation of GTPase activity; IEA:InterPro.
DR GO; GO:0007614; P:short-term memory; IMP:WormBase.
DR GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR Gene3D; 1.10.506.10; -; 2.
DR Gene3D; 2.60.40.150; -; 1.
DR InterPro; IPR000008; C2_dom.
DR InterPro; IPR035892; C2_domain_sf.
DR InterPro; IPR001849; PH_domain.
DR InterPro; IPR039360; Ras_GTPase.
DR InterPro; IPR023152; RasGAP_CS.
DR InterPro; IPR001936; RasGAP_dom.
DR InterPro; IPR008936; Rho_GTPase_activation_prot.
DR PANTHER; PTHR10194; PTHR10194; 1.
DR Pfam; PF00168; C2; 1.
DR Pfam; PF00616; RasGAP; 2.
DR SMART; SM00239; C2; 1.
DR SMART; SM00233; PH; 1.
DR SMART; SM00323; RasGAP; 1.
DR SUPFAM; SSF48350; SSF48350; 1.
DR SUPFAM; SSF49562; SSF49562; 1.
DR PROSITE; PS50004; C2; 1.
DR PROSITE; PS00509; RAS_GTPASE_ACTIV_1; 1.
DR PROSITE; PS50018; RAS_GTPASE_ACTIV_2; 1.
PE 2: Evidence at transcript level;
KW Alternative splicing; Cytoplasm; GTPase activation; Reference proteome.
FT CHAIN 1..1207
FT /note="Ras GTPase-activating protein gap-2"
FT /id="PRO_0000056664"
FT DOMAIN 40..383
FT /note="PH"
FT DOMAIN 374..490
FT /note="C2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00041"
FT DOMAIN 563..757
FT /note="Ras-GAP"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00167"
FT REGION 1..29
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 221..316
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 495..516
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 856..903
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 923..1013
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1086..1107
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1163..1207
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..20
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 221..262
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 281..296
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 858..879
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 889..903
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 923..950
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 951..982
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 983..1013
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1185..1200
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VAR_SEQ 1..489
FT /note="MKVIDEKPEDEEEEKDSGSKCKTPSSCTKKRVREKEEDLPPICHGWLIVCEG
FT NPTKMMNKEVKLPWHAGYCVFEPRQSTMSCYKQEYPFIAGRMLHRNRTVRMDGDRSAFA
FT RHWGLLPEHYPSPPITGPHTIARSYTRPPKDRLPTKERFFSISRIPSRLTKFSTVRGMS
FT IEFFDAIHDETNSGGAQVGGESLDRRGWSGASTGNRTTLTASVHNNLMNGRMSSSSHNL
FT STRLSGSTQNLNQPTNAYGNLLSRPFRSNPLKRTKSVSKMEKSLAEANQHSLHRVDASN
FT TPSRDSSLYAQPPARRHLSQPAREGSLRACRSHESLLSSAHSTHMIELNEDNRLHPVHP
FT SIFEVPNCFRLASTYYSCRTPLERAKWMENLRKTMNPRRDQQRRTENSMLIWILEAKGL
FT PAKRKYYCEMTLDKTLYAKTSSKARTDNVFWGENFEFMMLPKIDEVCVSLFRESDSKKK
FT KDTLIGYVTIGIDQLSSRSPVERW -> MRGEYDPWDPSFHNSSMIPYSLASIYPSIEN
FT LPEEFSNENNKIKNVLKNFIWSFKLKKNYVRVSSLFGEYCR (in isoform j)"
FT /evidence="ECO:0000305"
FT /id="VSP_058283"
FT VAR_SEQ 1..420
FT /note="Missing (in isoform g)"
FT /evidence="ECO:0000305"
FT /id="VSP_007797"
FT VAR_SEQ 1..381
FT /note="Missing (in isoform i)"
FT /id="VSP_058284"
FT VAR_SEQ 1..279
FT /note="MKVIDEKPEDEEEEKDSGSKCKTPSSCTKKRVREKEEDLPPICHGWLIVCEG
FT NPTKMMNKEVKLPWHAGYCVFEPRQSTMSCYKQEYPFIAGRMLHRNRTVRMDGDRSAFA
FT RHWGLLPEHYPSPPITGPHTIARSYTRPPKDRLPTKERFFSISRIPSRLTKFSTVRGMS
FT IEFFDAIHDETNSGGAQVGGESLDRRGWSGASTGNRTTLTASVHNNLMNGRMSSSSHNL
FT STRLSGSTQNLNQPTNAYGNLLSRPFRSNPLKRTKSVSKMEKSLAEANQH -> MKHMF
FT SIRSSSYTVNIPNQP (in isoform l)"
FT /evidence="ECO:0000305"
FT /id="VSP_058285"
FT VAR_SEQ 1..251
FT /note="Missing (in isoform f)"
FT /evidence="ECO:0000305"
FT /id="VSP_007795"
FT VAR_SEQ 1..174
FT /note="MKVIDEKPEDEEEEKDSGSKCKTPSSCTKKRVREKEEDLPPICHGWLIVCEG
FT NPTKMMNKEVKLPWHAGYCVFEPRQSTMSCYKQEYPFIAGRMLHRNRTVRMDGDRSAFA
FT RHWGLLPEHYPSPPITGPHTIARSYTRPPKDRLPTKERFFSISRIPSRLTKFSTVRGMS
FT IEFF -> MHRQGVHPNALHHLLLANKKRSNTTTCAHSTSSTPRSTYSSGSATSSLPLY
FT VNTHAVTEQPKAEKRVSFKDLDMSGRLPVTAQQPSSSSNHLRTGGGLHARKLHRCDTGN
FT MSLLERYLSRENMHTPSPIPQEYQPQANYSSRHVHFAQSQSRRPFQRDQRNENASIRKR
FT LSRSCDHLSDHNFSPRLPPIRRKPTKHVPSTLSLVIH (in isoform c)"
FT /evidence="ECO:0000305"
FT /id="VSP_007790"
FT VAR_SEQ 1..159
FT /note="Missing (in isoform e)"
FT /evidence="ECO:0000305"
FT /id="VSP_007793"
FT VAR_SEQ 1..119
FT /note="Missing (in isoform h)"
FT /evidence="ECO:0000305"
FT /id="VSP_007799"
FT VAR_SEQ 1..90
FT /note="Missing (in isoform d)"
FT /evidence="ECO:0000303|PubMed:9619631"
FT /id="VSP_007791"
FT VAR_SEQ 1..57
FT /note="Missing (in isoform b)"
FT /evidence="ECO:0000305"
FT /id="VSP_007788"
FT VAR_SEQ 91..174
FT /note="AGRMLHRNRTVRMDGDRSAFARHWGLLPEHYPSPPITGPHTIARSYTRPPKD
FT RLPTKERFFSISRIPSRLTKFSTVRGMSIEFF -> MHTPSPIPQEYQPQANYSSRHVH
FT FAQSQSRRPFQRDQRNENASIRKRLSRSCDHLSDHNFSPRLPPIRRKPTKHVPSTLSLV
FT IH (in isoform d)"
FT /evidence="ECO:0000303|PubMed:9619631"
FT /id="VSP_007792"
FT VAR_SEQ 120..174
FT /note="HYPSPPITGPHTIARSYTRPPKDRLPTKERFFSISRIPSRLTKFSTVRGMSI
FT EFF -> MRRYGISPWYSQSTYSLNIIPEEYVPPVDYDIDFR (in isoform h)"
FT /evidence="ECO:0000305"
FT /id="VSP_007800"
FT VAR_SEQ 160..174
FT /note="LTKFSTVRGMSIEFF -> METFDIRPSKYGSVR (in isoform e)"
FT /evidence="ECO:0000305"
FT /id="VSP_007794"
FT VAR_SEQ 248
FT /note="G -> GFPIVPPANNPSDSSASGRIA (in isoform b, isoform c,
FT isoform d and isoform h)"
FT /evidence="ECO:0000303|PubMed:9619631"
FT /id="VSP_007789"
FT VAR_SEQ 252..279
FT /note="SRPFRSNPLKRTKSVSKMEKSLAEANQH -> MQCLSPNREKHNANPRLVRG
FT RIVYKSKR (in isoform f)"
FT /evidence="ECO:0000305"
FT /id="VSP_007796"
FT VAR_SEQ 421..489
FT /note="TLYAKTSSKARTDNVFWGENFEFMMLPKIDEVCVSLFRESDSKKKKDTLIGY
FT VTIGIDQLSSRSPVERW -> MRGEYDPWDPSFHNSSMIPYSLASIYPSIENLPEEFSN
FT ENNKIKNVLKNFIWSFKLKKNYVRVSSLFGE (in isoform g)"
FT /evidence="ECO:0000305"
FT /id="VSP_007798"
FT VAR_SEQ 1069..1070
FT /note="Missing (in isoform k)"
FT /evidence="ECO:0000305"
FT /id="VSP_058286"
FT CONFLICT 1028
FT /note="V -> C (in Ref. 1; BAA24960)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 1207 AA; 136247 MW; EA222578D689795F CRC64;
MKVIDEKPED EEEEKDSGSK CKTPSSCTKK RVREKEEDLP PICHGWLIVC EGNPTKMMNK
EVKLPWHAGY CVFEPRQSTM SCYKQEYPFI AGRMLHRNRT VRMDGDRSAF ARHWGLLPEH
YPSPPITGPH TIARSYTRPP KDRLPTKERF FSISRIPSRL TKFSTVRGMS IEFFDAIHDE
TNSGGAQVGG ESLDRRGWSG ASTGNRTTLT ASVHNNLMNG RMSSSSHNLS TRLSGSTQNL
NQPTNAYGNL LSRPFRSNPL KRTKSVSKME KSLAEANQHS LHRVDASNTP SRDSSLYAQP
PARRHLSQPA REGSLRACRS HESLLSSAHS THMIELNEDN RLHPVHPSIF EVPNCFRLAS
TYYSCRTPLE RAKWMENLRK TMNPRRDQQR RTENSMLIWI LEAKGLPAKR KYYCEMTLDK
TLYAKTSSKA RTDNVFWGEN FEFMMLPKID EVCVSLFRES DSKKKKDTLI GYVTIGIDQL
SSRSPVERWY TVNTSHSDSG TSRIASALGG KSSSQESPSL RIKARWQSVH ILPLRAYDNL
LETLCYNYLP LCEQLEPVLN VRDKEDLATS LVRVMYKHNL AKEFLCDLIM KEVEKLDNDH
LMFRGNTLAT KAMESFMKLV ADDYLDSTLS DFIKTVLQCE DSCEVDPQKL GNVSNSSLEK
NRALLMRYVE VAWTKILNNV HQLPKNLRDV FSALRCRLEA QNREALADTL ISSSIFLRFL
CPAILSPSLF NLVSEYPSPT NARNLTLIAK TLQNLANFSK FGGKEPHMEF MNEFVDREWH
RMKDFLLRIS SESKSGPEKN ADAIVDAGKE LSLIATYLEE AWTPLLQEKN GNKHPLSNVK
SVLSELAECK RRSDNGVFHS PMVQQPSSDY ENSPQQHVVP RHENVPAYRS TPPTGQATVL
GRSTNRPATH LLTSDDYVLS SAFQTPSLRP GGTRLSDETG TSSSRTSDKT TSSAEIRDDT
DSDFELREDR GRGGRNRKRL PRTDASPSSS QQASSGYLSN NPSRSSYSNS SSSSPVERMA
ALSIANPVFG PGPSSGYAIP AEPKEIVYQK RASPPPYDPD VHNYHYQPMQ VYAVPPDCQV
SPRTQATGGV NAQNRLSLPR TNPRASRNST LLRPSVVNVP DDWDRTSDYW RDRGENNYRS
QLESQVESQA REIERLMREN IELKSKMMSS TKTVDSKRSD SGASEDSYDS LSSLDRPSRQ
SLVVVPN
