ID   GAP5_CANAL              Reviewed;         618 AA.
AC   A0A1D8PMB1;
DT   10-MAY-2017, integrated into UniProtKB/Swiss-Prot.
DT   18-JAN-2017, sequence version 1.
DT   25-MAY-2022, entry version 25.
DE   RecName: Full=Amino-acid permease GAP5;
GN   Name=GAP5; OrderedLocusNames=CAALFM_C405430CA;
OS   Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Debaryomycetaceae; Candida/Lodderomyces clade; Candida.
OX   NCBI_TaxID=237561;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=SC5314 / ATCC MYA-2876;
RX   PubMed=15123810; DOI=10.1073/pnas.0401648101;
RA   Jones T., Federspiel N.A., Chibana H., Dungan J., Kalman S., Magee B.B.,
RA   Newport G., Thorstenson Y.R., Agabian N., Magee P.T., Davis R.W.,
RA   Scherer S.;
RT   "The diploid genome sequence of Candida albicans.";
RL   Proc. Natl. Acad. Sci. U.S.A. 101:7329-7334(2004).
RN   [2]
RP   GENOME REANNOTATION.
RC   STRAIN=SC5314 / ATCC MYA-2876;
RX   PubMed=17419877; DOI=10.1186/gb-2007-8-4-r52;
RA   van het Hoog M., Rast T.J., Martchenko M., Grindle S., Dignard D.,
RA   Hogues H., Cuomo C., Berriman M., Scherer S., Magee B.B., Whiteway M.,
RA   Chibana H., Nantel A., Magee P.T.;
RT   "Assembly of the Candida albicans genome into sixteen supercontigs aligned
RT   on the eight chromosomes.";
RL   Genome Biol. 8:RESEARCH52.1-RESEARCH52.12(2007).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], AND GENOME REANNOTATION.
RC   STRAIN=SC5314 / ATCC MYA-2876;
RX   PubMed=24025428; DOI=10.1186/gb-2013-14-9-r97;
RA   Muzzey D., Schwartz K., Weissman J.S., Sherlock G.;
RT   "Assembly of a phased diploid Candida albicans genome facilitates allele-
RT   specific measurements and provides a simple model for repeat and indel
RT   structure.";
RL   Genome Biol. 14:RESEARCH97.1-RESEARCH97.14(2013).
RN   [4]
RP   FUNCTION, AND SUBCELLULAR LOCATION.
RX   PubMed=21764911; DOI=10.1128/ec.05026-11;
RA   Kraidlova L., Van Zeebroeck G., Van Dijck P., Sychrova H.;
RT   "The Candida albicans GAP gene family encodes permeases involved in general
RT   and specific amino acid uptake and sensing.";
RL   Eukaryot. Cell 10:1219-1229(2011).
RN   [5]
RP   FUNCTION, INDUCTION, AND SUBCELLULAR LOCATION.
RX   PubMed=28028545; DOI=10.1128/msphere.00284-16;
RA   Kraidlova L., Schrevens S., Tournu H., Van Zeebroeck G., Sychrova H.,
RA   Van Dijck P.;
RT   "Characterization of the Candida albicans amino acid permease family: Gap2
RT   is the only general amino acid permease and Gap4 is an S-adenosylmethionine
RT   (SAM) transporter required for SAM-induced morphogenesis.";
RL   MSphere 1:0-0(2016).
CC   -!- FUNCTION: Amino-acid permease that is able to transport phenylalanine
CC       (PubMed:21764911, PubMed:28028545). {ECO:0000269|PubMed:21764911,
CC       ECO:0000269|PubMed:28028545}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:21764911,
CC       ECO:0000269|PubMed:28028545}; Multi-pass membrane protein
CC       {ECO:0000255}.
CC   -!- INDUCTION: Expression is under control of the CSY1 amino-acid sensor
CC       (PubMed:28028545). {ECO:0000269|PubMed:28028545}.
CC   -!- SIMILARITY: Belongs to the amino acid-polyamine-organocation (APC)
CC       superfamily. YAT (TC 2.A.3.10) family. {ECO:0000305}.
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DR   EMBL; CP017626; AOW29281.1; -; Genomic_DNA.
DR   RefSeq; XP_711447.2; XM_706355.2.
DR   AlphaFoldDB; A0A1D8PMB1; -.
DR   SMR; A0A1D8PMB1; -.
DR   STRING; 237561.A0A1D8PMB1; -.
DR   GeneID; 3646954; -.
DR   KEGG; cal:CAALFM_C405430CA; -.
DR   CGD; CAL0000182050; GAP5.
DR   VEuPathDB; FungiDB:C4_05430C_A; -.
DR   OMA; YIGWEPA; -.
DR   OrthoDB; 600052at2759; -.
DR   Proteomes; UP000000559; Chromosome 4.
DR   GO; GO:0016021; C:integral component of membrane; IBA:GO_Central.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0015171; F:amino acid transmembrane transporter activity; IDA:CGD.
DR   GO; GO:0003333; P:amino acid transmembrane transport; IMP:CGD.
DR   InterPro; IPR004841; AA-permease/SLC12A_dom.
DR   InterPro; IPR004762; Amino_acid_permease_fungi.
DR   InterPro; IPR004840; Amoino_acid_permease_CS.
DR   Pfam; PF00324; AA_permease; 1.
DR   TIGRFAMs; TIGR00913; 2A0310; 1.
DR   PROSITE; PS00218; AMINO_ACID_PERMEASE_1; 1.
PE   2: Evidence at transcript level;
KW   Amino-acid transport; Cell membrane; Glycoprotein; Membrane;
KW   Reference proteome; Transmembrane; Transmembrane helix; Transport.
FT   CHAIN           1..618
FT                   /note="Amino-acid permease GAP5"
FT                   /id="PRO_0000439810"
FT   TRANSMEM        121..143
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        148..170
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        193..213
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        229..249
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        254..274
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        302..322
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        341..361
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        397..419
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        439..459
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        465..485
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        517..537
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        546..566
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   REGION          1..55
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   CARBOHYD        9
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00498"
FT   CARBOHYD        90
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00498"
FT   CARBOHYD        104
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00498"
SQ   SEQUENCE   618 AA;  68203 MW;  703BD24D43CA16B0 CRC64;
     MSKKYSEENT SSIPLTDLTS PSTGETSSQQ QRQRASQQQP PQQPESNTAT GSRWSNFVDS
     FKPAIENEKL AMRYRDANAD VEEDAGGYYN STDQLTEIQR ININSSKSNL KRKLKNRHLQ
     MIAIASSIGS GLLIGTGGAL ATGGPGGILI AWILSGISIL CTIQAMAELA VTFPVSGGFN
     VLFSRFIDPS VGFSVAWNYV LQYLVLLPLE LVAASMTIQY WNTDINPDVW VIIFYVTVTS
     INFFGVRLYG EVEFILSSLK VIAVVGFIIL SIVLAAGGAP NGVHHGTKYW HDPGAFANGF
     KGVSSTFITA AFSFAGTELT GLTSAEAENP RKALPKACKQ VFWRILLFYV VSIILITFLV
     PYDNPRLLGA SDVSASPFVI AIQDGGISGL ASVMNSVILI SVISVGSSSV YATSRTLVSL
     AEQNLAPKIC GYVDRAGRPL VAILITNVFG LLSFIAASGK EDEVFTWLLS ISGLSSIFTW
     LCICISHIRF RRALHVQGRN TDELTFVSQT GVIGSWFGIL LNVLVLVAEF WLAIFPLGEK
     SNAKSFFETY LGFVILIIFY FGHKLWRNNW ILFIRSRDID IDSGRRETDL EALKRELQEE
     REVLRNKPFW YRAYHFWC