GAPR1_MOUSE
ID GAPR1_MOUSE Reviewed; 154 AA.
AC Q9CYL5; Q3TJ42; Q8BTK4;
DT 29-MAR-2004, integrated into UniProtKB/Swiss-Prot.
DT 23-JAN-2007, sequence version 3.
DT 03-AUG-2022, entry version 135.
DE RecName: Full=Golgi-associated plant pathogenesis-related protein 1;
DE Short=GAPR-1;
DE Short=Golgi-associated PR-1 protein;
DE AltName: Full=Glioma pathogenesis-related protein 2;
DE Short=GliPR 2;
GN Name=Glipr2; Synonyms=Gapr1;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J, and NOD; TISSUE=Embryo;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Mammary tumor;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [3]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Brown adipose tissue, Heart, Kidney, Liver, Lung, Pancreas, and
RC Spleen;
RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL Cell 143:1174-1189(2010).
CC -!- SUBUNIT: Homodimer. Interacts with CAV1 (By similarity). {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Golgi apparatus membrane; Lipid-anchor.
CC Note=Binds lipid-enriched microdomains of Golgi membranes not only by
CC ionic interactions but also through the myristate.
CC {ECO:0000250|UniProtKB:Q9H4G4}.
CC -!- SIMILARITY: Belongs to the CRISP family. {ECO:0000305}.
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DR EMBL; AK017557; BAB30803.1; -; mRNA.
DR EMBL; AK089960; BAC41014.1; -; mRNA.
DR EMBL; AK154433; BAE32583.1; -; mRNA.
DR EMBL; AK167595; BAE39653.1; -; mRNA.
DR EMBL; BC031750; AAH31750.1; -; mRNA.
DR CCDS; CCDS18117.1; -.
DR RefSeq; NP_081726.1; NM_027450.3.
DR AlphaFoldDB; Q9CYL5; -.
DR SMR; Q9CYL5; -.
DR BioGRID; 239009; 5.
DR IntAct; Q9CYL5; 2.
DR STRING; 10090.ENSMUSP00000030202; -.
DR iPTMnet; Q9CYL5; -.
DR PhosphoSitePlus; Q9CYL5; -.
DR SwissPalm; Q9CYL5; -.
DR EPD; Q9CYL5; -.
DR MaxQB; Q9CYL5; -.
DR PaxDb; Q9CYL5; -.
DR PeptideAtlas; Q9CYL5; -.
DR PRIDE; Q9CYL5; -.
DR ProteomicsDB; 273027; -.
DR Antibodypedia; 26141; 165 antibodies from 19 providers.
DR DNASU; 384009; -.
DR Ensembl; ENSMUST00000030202; ENSMUSP00000030202; ENSMUSG00000028480.
DR GeneID; 384009; -.
DR KEGG; mmu:384009; -.
DR UCSC; uc008srf.1; mouse.
DR CTD; 152007; -.
DR MGI; MGI:1917770; Glipr2.
DR VEuPathDB; HostDB:ENSMUSG00000028480; -.
DR eggNOG; KOG3017; Eukaryota.
DR GeneTree; ENSGT00390000020276; -.
DR HOGENOM; CLU_035730_9_2_1; -.
DR InParanoid; Q9CYL5; -.
DR OMA; NTCAWNK; -.
DR OrthoDB; 1528782at2759; -.
DR PhylomeDB; Q9CYL5; -.
DR TreeFam; TF313138; -.
DR BioGRID-ORCS; 384009; 1 hit in 74 CRISPR screens.
DR PRO; PR:Q9CYL5; -.
DR Proteomes; UP000000589; Chromosome 4.
DR RNAct; Q9CYL5; protein.
DR Bgee; ENSMUSG00000028480; Expressed in granulocyte and 155 other tissues.
DR ExpressionAtlas; Q9CYL5; baseline and differential.
DR Genevisible; Q9CYL5; MM.
DR GO; GO:0005615; C:extracellular space; IBA:GO_Central.
DR GO; GO:0000139; C:Golgi membrane; ISO:MGI.
DR GO; GO:0042803; F:protein homodimerization activity; ISO:MGI.
DR GO; GO:0010634; P:positive regulation of epithelial cell migration; ISO:MGI.
DR GO; GO:0010718; P:positive regulation of epithelial to mesenchymal transition; ISO:MGI.
DR GO; GO:0070374; P:positive regulation of ERK1 and ERK2 cascade; ISO:MGI.
DR CDD; cd05382; CAP_GAPR1-like; 1.
DR Gene3D; 3.40.33.10; -; 1.
DR InterPro; IPR018244; Allrgn_V5/Tpx1_CS.
DR InterPro; IPR014044; CAP_domain.
DR InterPro; IPR035940; CAP_sf.
DR InterPro; IPR001283; CRISP-related.
DR InterPro; IPR034113; SCP_GAPR1-like.
DR PANTHER; PTHR10334; PTHR10334; 1.
DR Pfam; PF00188; CAP; 1.
DR PRINTS; PR00837; V5TPXLIKE.
DR SMART; SM00198; SCP; 1.
DR SUPFAM; SSF55797; SSF55797; 1.
DR PROSITE; PS01009; CRISP_1; 1.
PE 1: Evidence at protein level;
KW Coiled coil; Golgi apparatus; Lipoprotein; Membrane; Myristate;
KW Reference proteome.
FT INIT_MET 1
FT /note="Removed"
FT /evidence="ECO:0000250|UniProtKB:Q9H4G4"
FT CHAIN 2..154
FT /note="Golgi-associated plant pathogenesis-related protein
FT 1"
FT /id="PRO_0000211525"
FT DOMAIN 14..132
FT /note="SCP"
FT REGION 91..98
FT /note="Interaction with CAV1"
FT /evidence="ECO:0000250"
FT COILED 30..50
FT /evidence="ECO:0000255"
FT LIPID 2
FT /note="N-myristoyl glycine"
FT /evidence="ECO:0000250|UniProtKB:Q9H4G4"
FT CONFLICT 54
FT /note="H -> R (in Ref. 1; BAC41014)"
FT /evidence="ECO:0000305"
FT CONFLICT 75
FT /note="T -> A (in Ref. 1; BAC41014)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 154 AA; 17090 MW; 0F00D6180D0B5FFD CRC64;
MGKSASKQFN NEVLKAHNEY RAQHGVPPLK LCKKLNREAQ QYSEALASTR ILKHSPESSR
GQCGENLAWA SYDQTGKDVA DRWYSEIKSY NFQQPGFTSG TGHFTAMVWK NTKKIGVGKA
SASDGSSFVV ARYFPAGNIV NQGFFEENVP PPKK
