ID   GAR1B_BOVIN             Reviewed;         345 AA.
AC   Q2KIP3;
DT   13-NOV-2007, integrated into UniProtKB/Swiss-Prot.
DT   07-MAR-2006, sequence version 1.
DT   03-AUG-2022, entry version 69.
DE   RecName: Full=Golgi associated RAB2 interactor protein 1B;
GN   Name=GARIN1B; Synonyms=FAM137A, FAM71F1;
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=Hereford; TISSUE=Testis;
RG   NIH - Mammalian Gene Collection (MGC) project;
RL   Submitted (JAN-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: RAB2B effector protein required for accurate acrosome
CC       formation and normal male fertility. In complex with RAB2A/RAB2B, seems
CC       to suppress excessive vesicle trafficking during acrosome formation.
CC       {ECO:0000250|UniProtKB:Q3UZD7}.
CC   -!- SUBCELLULAR LOCATION: Golgi apparatus {ECO:0000250|UniProtKB:Q3UZD7}.
CC   -!- SIMILARITY: Belongs to the GARIN family. {ECO:0000305}.
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DR   EMBL; BC112564; AAI12565.1; -; mRNA.
DR   RefSeq; NP_001039922.1; NM_001046457.2.
DR   AlphaFoldDB; Q2KIP3; -.
DR   STRING; 9913.ENSBTAP00000013015; -.
DR   PaxDb; Q2KIP3; -.
DR   PRIDE; Q2KIP3; -.
DR   Ensembl; ENSBTAT00000013015; ENSBTAP00000013015; ENSBTAG00000009867.
DR   GeneID; 539444; -.
DR   KEGG; bta:539444; -.
DR   CTD; 84691; -.
DR   VEuPathDB; HostDB:ENSBTAG00000009867; -.
DR   VGNC; VGNC:50157; GARIN1B.
DR   eggNOG; ENOG502S7XV; Eukaryota.
DR   GeneTree; ENSGT00940000161477; -.
DR   HOGENOM; CLU_069391_0_0_1; -.
DR   InParanoid; Q2KIP3; -.
DR   OMA; PDHPQTV; -.
DR   OrthoDB; 1360447at2759; -.
DR   TreeFam; TF336050; -.
DR   Proteomes; UP000009136; Chromosome 4.
DR   Bgee; ENSBTAG00000009867; Expressed in semen and 33 other tissues.
DR   ExpressionAtlas; Q2KIP3; baseline.
DR   GO; GO:0005794; C:Golgi apparatus; ISS:UniProtKB.
DR   GO; GO:0001675; P:acrosome assembly; ISS:UniProtKB.
DR   GO; GO:0007340; P:acrosome reaction; ISS:UniProtKB.
DR   InterPro; IPR022168; DUF3699.
DR   Pfam; PF12480; DUF3699; 1.
PE   2: Evidence at transcript level;
KW   Golgi apparatus; Reference proteome.
FT   CHAIN           1..345
FT                   /note="Golgi associated RAB2 interactor protein 1B"
FT                   /id="PRO_0000311686"
FT   REGION          222..241
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          271..299
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        271..288
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   345 AA;  38852 MW;  67249D2444D84916 CRC64;
     MLSSVPHRKT WNKSKKTVKV TRSYPTFPSL NAWEEFRGLF PVDGEPNPGV GLGVEEGLLG
     QMVHSPEFNL FPESVVFESN FVQVRKGRDW IDIYKTYNTM ALGVTSSVPC LPLPNILLMA
     SVKWHHGQNQ TWNKPSTAPK IILKRILPLK FVELQVSDHL QRVLRLRTVT EKIYYLKLHP
     DHPKTVFHFW IRLIQILQKG LSITTKDPRI LVTHCLVPKN SCSPSGDSQL VQKKPQASQP
     SESLMQLMAK GESEALCQIF VDLHQHNLFS SRSSKKTENK KDSSGKKTSP SEDSIPCTRD
     LSWRDSFTYG EWERENPSGP QSLSLLSTLA ASTGPQLAPL IGSSI