ID   GAR1_BOTFB              Reviewed;         221 AA.
AC   A6SDR8;
DT   08-APR-2008, integrated into UniProtKB/Swiss-Prot.
DT   21-AUG-2007, sequence version 1.
DT   25-MAY-2022, entry version 73.
DE   RecName: Full=H/ACA ribonucleoprotein complex subunit GAR1;
DE   AltName: Full=snoRNP protein GAR1;
GN   Name=GAR1; ORFNames=BC1G_11335;
OS   Botryotinia fuckeliana (strain B05.10) (Noble rot fungus) (Botrytis
OS   cinerea).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Leotiomycetes;
OC   Helotiales; Sclerotiniaceae; Botrytis.
OX   NCBI_TaxID=332648;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=B05.10;
RX   PubMed=21876677; DOI=10.1371/journal.pgen.1002230;
RA   Amselem J., Cuomo C.A., van Kan J.A.L., Viaud M., Benito E.P., Couloux A.,
RA   Coutinho P.M., de Vries R.P., Dyer P.S., Fillinger S., Fournier E.,
RA   Gout L., Hahn M., Kohn L., Lapalu N., Plummer K.M., Pradier J.-M.,
RA   Quevillon E., Sharon A., Simon A., ten Have A., Tudzynski B., Tudzynski P.,
RA   Wincker P., Andrew M., Anthouard V., Beever R.E., Beffa R., Benoit I.,
RA   Bouzid O., Brault B., Chen Z., Choquer M., Collemare J., Cotton P.,
RA   Danchin E.G., Da Silva C., Gautier A., Giraud C., Giraud T., Gonzalez C.,
RA   Grossetete S., Gueldener U., Henrissat B., Howlett B.J., Kodira C.,
RA   Kretschmer M., Lappartient A., Leroch M., Levis C., Mauceli E.,
RA   Neuveglise C., Oeser B., Pearson M., Poulain J., Poussereau N.,
RA   Quesneville H., Rascle C., Schumacher J., Segurens B., Sexton A., Silva E.,
RA   Sirven C., Soanes D.M., Talbot N.J., Templeton M., Yandava C., Yarden O.,
RA   Zeng Q., Rollins J.A., Lebrun M.-H., Dickman M.;
RT   "Genomic analysis of the necrotrophic fungal pathogens Sclerotinia
RT   sclerotiorum and Botrytis cinerea.";
RL   PLoS Genet. 7:E1002230-E1002230(2011).
CC   -!- FUNCTION: Non-catalytic component of the H/ACA small nucleolar
CC       ribonucleoprotein (H/ACA snoRNP), which catalyzes pseudouridylation of
CC       rRNA and is required for ribosome biogenesis. This involves the
CC       isomerization of uridine such that the ribose is subsequently attached
CC       to C5, instead of the normal N1. Pseudouridine ('psi') residues may
CC       serve to stabilize the conformation of rRNAs. The H/ACA snoRNP complex
CC       also mediates pseudouridylation of other types of RNAs. The H/ACA
CC       snoRNP complex mediates pseudouridylation at position 93 in U2 snRNA.
CC       {ECO:0000250|UniProtKB:P28007}.
CC   -!- SUBUNIT: Component of the small nucleolar ribonucleoprotein particles
CC       containing H/ACA-type snoRNAs (H/ACA snoRNPs).
CC       {ECO:0000250|UniProtKB:P28007}.
CC   -!- SUBCELLULAR LOCATION: Nucleus, nucleolus
CC       {ECO:0000250|UniProtKB:P28007}.
CC   -!- SIMILARITY: Belongs to the GAR1 family. {ECO:0000305}.
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DR   EMBL; CH476918; EDN31850.1; -; Genomic_DNA.
DR   RefSeq; XP_001550562.1; XM_001550512.1.
DR   AlphaFoldDB; A6SDR8; -.
DR   SMR; A6SDR8; -.
DR   GeneID; 5431046; -.
DR   KEGG; bfu:BCIN_02g06650; -.
DR   VEuPathDB; FungiDB:Bcin02g06650; -.
DR   OMA; HSCEGEM; -.
DR   OrthoDB; 1508842at2759; -.
DR   GO; GO:0031429; C:box H/ACA snoRNP complex; IEA:EnsemblFungi.
DR   GO; GO:0034513; F:box H/ACA snoRNA binding; IEA:EnsemblFungi.
DR   GO; GO:0000454; P:snoRNA guided rRNA pseudouridine synthesis; IEA:EnsemblFungi.
DR   GO; GO:0031120; P:snRNA pseudouridine synthesis; IEA:EnsemblFungi.
DR   Gene3D; 2.40.10.230; -; 1.
DR   InterPro; IPR038664; Gar1/Naf1_Cbf5-bd_sf.
DR   InterPro; IPR007504; H/ACA_rnp_Gar1/Naf1.
DR   InterPro; IPR009000; Transl_B-barrel_sf.
DR   Pfam; PF04410; Gar1; 1.
DR   SUPFAM; SSF50447; SSF50447; 1.
PE   3: Inferred from homology;
KW   Nucleus; Repeat; Ribonucleoprotein; Ribosome biogenesis; RNA-binding;
KW   rRNA processing.
FT   CHAIN           1..221
FT                   /note="H/ACA ribonucleoprotein complex subunit GAR1"
FT                   /id="PRO_0000327524"
FT   REGION          1..42
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          4..35
FT                   /note="RGG-box 1"
FT   REGION          130..221
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          152..220
FT                   /note="RGG-box 2"
SQ   SEQUENCE   221 AA;  22195 MW;  123C7E1334F99E5B CRC64;
     MSFRGGSRGG RGTGANAGFS GGRGGFGGRG GGRGGFQQRD NGPPADVFAM GSFLHASEGE
     IVCESINTKI PYFNAPIYLE NKTSIGKVDE ILGPINQVYF TIKPTEGIQA TSFKTGDKFY
     IGGDKLLPLE KFLPKPKPPP GAPKPKRAGG ARGGRGGPMR GGRGGGRGAP RGGRGGFTPR
     GGSGGFSRGG GGGGFSRGGG GFTPRGGARG GSRGGFSRGG R