GAR1_CAEBR
ID GAR1_CAEBR Reviewed; 246 AA.
AC Q61B10; A8XI51;
DT 05-JUL-2005, integrated into UniProtKB/Swiss-Prot.
DT 23-NOV-2004, sequence version 1.
DT 03-AUG-2022, entry version 81.
DE RecName: Full=Probable H/ACA ribonucleoprotein complex subunit 1-like protein;
GN ORFNames=CBG13541;
OS Caenorhabditis briggsae.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC Caenorhabditis.
OX NCBI_TaxID=6238;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AF16;
RX PubMed=14624247; DOI=10.1371/journal.pbio.0000045;
RA Stein L.D., Bao Z., Blasiar D., Blumenthal T., Brent M.R., Chen N.,
RA Chinwalla A., Clarke L., Clee C., Coghlan A., Coulson A., D'Eustachio P.,
RA Fitch D.H.A., Fulton L.A., Fulton R.E., Griffiths-Jones S., Harris T.W.,
RA Hillier L.W., Kamath R., Kuwabara P.E., Mardis E.R., Marra M.A.,
RA Miner T.L., Minx P., Mullikin J.C., Plumb R.W., Rogers J., Schein J.E.,
RA Sohrmann M., Spieth J., Stajich J.E., Wei C., Willey D., Wilson R.K.,
RA Durbin R.M., Waterston R.H.;
RT "The genome sequence of Caenorhabditis briggsae: a platform for comparative
RT genomics.";
RL PLoS Biol. 1:166-192(2003).
CC -!- FUNCTION: Required for ribosome biogenesis. Part of a complex which
CC catalyzes pseudouridylation of rRNA. This involves the isomerization of
CC uridine such that the ribose is subsequently attached to C5, instead of
CC the normal N1. Pseudouridine ('psi') residues may serve to stabilize
CC the conformation of rRNAs (By similarity). {ECO:0000250}.
CC -!- SUBUNIT: Component of the small nucleolar ribonucleoprotein particle
CC containing H/ACA-type snoRNAs (H/ACA snoRNPs). {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Nucleus, nucleolus {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the GAR1 family. {ECO:0000305}.
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DR EMBL; HE600980; CAP32325.1; -; Genomic_DNA.
DR RefSeq; XP_002635001.1; XM_002634955.1.
DR AlphaFoldDB; Q61B10; -.
DR SMR; Q61B10; -.
DR STRING; 6238.CBG13541; -.
DR EnsemblMetazoa; CBG13541.1; CBG13541.1; WBGene00034295.
DR GeneID; 8576996; -.
DR KEGG; cbr:CBG_13541; -.
DR CTD; 8576996; -.
DR WormBase; CBG13541; CBP03265; WBGene00034295; -.
DR eggNOG; KOG3262; Eukaryota.
DR HOGENOM; CLU_080002_0_0_1; -.
DR InParanoid; Q61B10; -.
DR OMA; VCKVDIQ; -.
DR OrthoDB; 1530008at2759; -.
DR Proteomes; UP000008549; Chromosome IV.
DR GO; GO:0031429; C:box H/ACA snoRNP complex; IBA:GO_Central.
DR GO; GO:0034513; F:box H/ACA snoRNA binding; IBA:GO_Central.
DR GO; GO:0000454; P:snoRNA guided rRNA pseudouridine synthesis; IBA:GO_Central.
DR Gene3D; 2.40.10.230; -; 1.
DR InterPro; IPR038664; Gar1/Naf1_Cbf5-bd_sf.
DR InterPro; IPR007504; H/ACA_rnp_Gar1/Naf1.
DR InterPro; IPR009000; Transl_B-barrel_sf.
DR Pfam; PF04410; Gar1; 1.
DR SUPFAM; SSF50447; SSF50447; 1.
PE 3: Inferred from homology;
KW Nucleus; Reference proteome; Repeat; Ribonucleoprotein;
KW Ribosome biogenesis; RNA-binding; rRNA processing.
FT CHAIN 1..246
FT /note="Probable H/ACA ribonucleoprotein complex subunit 1-
FT like protein"
FT /id="PRO_0000208557"
FT REGION 1..61
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 4..59
FT /note="RGG-box 1"
FT REGION 155..246
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 161..223
FT /note="RGG-box 2"
FT COMPBIAS 165..179
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 246 AA; 24385 MW; 3688788B9EBAB04A CRC64;
MSFRGGRGGG GGGGFRGGRG GGGGGGFRGG RGGDRGGGGF RGGRGGGGRG GFGGGGRGGY
DQGPPEEVVL VGVFSHKCQD DIVCNNTSGK IPYFNAPIYF ENKEQVGKID EIFGSPGENG
FSVTLSQGVK ASSFKSGSEL YIDPGKLLPV ERFLPQVGGG RGRGGRGRGG DRGRGGDRGR
GGFGGRGGGG GGFRGGSRGG FGGGDRGGFR GGRGGDFGGR GRGGDFKRSY DGGGYGGNSN
KRTKFD
