GAR1_CAEEL
ID GAR1_CAEEL Reviewed; 244 AA.
AC Q9TYK1;
DT 31-AUG-2004, integrated into UniProtKB/Swiss-Prot.
DT 31-AUG-2004, sequence version 2.
DT 03-AUG-2022, entry version 116.
DE RecName: Full=Probable H/ACA ribonucleoprotein complex subunit 1-like protein;
GN ORFNames=Y66H1A.4;
OS Caenorhabditis elegans.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC Caenorhabditis.
OX NCBI_TaxID=6239;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Bristol N2;
RX PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG The C. elegans sequencing consortium;
RT "Genome sequence of the nematode C. elegans: a platform for investigating
RT biology.";
RL Science 282:2012-2018(1998).
CC -!- FUNCTION: Required for ribosome biogenesis. Part of a complex which
CC catalyzes pseudouridylation of rRNA. This involves the isomerization of
CC uridine such that the ribose is subsequently attached to C5, instead of
CC the normal N1. Pseudouridine ('psi') residues may serve to stabilize
CC the conformation of rRNAs (By similarity). {ECO:0000250}.
CC -!- SUBUNIT: Component of the small nucleolar ribonucleoprotein particle
CC containing H/ACA-type snoRNAs (H/ACA snoRNPs). {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Nucleus, nucleolus {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the GAR1 family. {ECO:0000305}.
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DR EMBL; FO081659; CCD73147.1; -; Genomic_DNA.
DR PIR; T33925; T33925.
DR RefSeq; NP_499927.2; NM_067526.3.
DR AlphaFoldDB; Q9TYK1; -.
DR SMR; Q9TYK1; -.
DR BioGRID; 42031; 21.
DR STRING; 6239.Y66H1A.4.2; -.
DR iPTMnet; Q9TYK1; -.
DR EPD; Q9TYK1; -.
DR PaxDb; Q9TYK1; -.
DR PeptideAtlas; Q9TYK1; -.
DR EnsemblMetazoa; Y66H1A.4.1; Y66H1A.4.1; WBGene00022046.
DR GeneID; 176870; -.
DR KEGG; cel:CELE_Y66H1A.4; -.
DR UCSC; Y66H1A.4.1; c. elegans.
DR CTD; 176870; -.
DR WormBase; Y66H1A.4; CE36757; WBGene00022046; -.
DR eggNOG; KOG3262; Eukaryota.
DR GeneTree; ENSGT00730000111223; -.
DR HOGENOM; CLU_080002_0_0_1; -.
DR InParanoid; Q9TYK1; -.
DR OMA; EVGYFTH; -.
DR OrthoDB; 1530008at2759; -.
DR PRO; PR:Q9TYK1; -.
DR Proteomes; UP000001940; Chromosome IV.
DR Bgee; WBGene00022046; Expressed in adult organism and 4 other tissues.
DR GO; GO:0031429; C:box H/ACA snoRNP complex; IBA:GO_Central.
DR GO; GO:0034513; F:box H/ACA snoRNA binding; IBA:GO_Central.
DR GO; GO:0000454; P:snoRNA guided rRNA pseudouridine synthesis; IBA:GO_Central.
DR Gene3D; 2.40.10.230; -; 1.
DR InterPro; IPR038664; Gar1/Naf1_Cbf5-bd_sf.
DR InterPro; IPR007504; H/ACA_rnp_Gar1/Naf1.
DR InterPro; IPR009000; Transl_B-barrel_sf.
DR Pfam; PF04410; Gar1; 1.
DR SUPFAM; SSF50447; SSF50447; 1.
PE 3: Inferred from homology;
KW Nucleus; Reference proteome; Repeat; Ribonucleoprotein;
KW Ribosome biogenesis; RNA-binding; rRNA processing.
FT CHAIN 1..244
FT /note="Probable H/ACA ribonucleoprotein complex subunit 1-
FT like protein"
FT /id="PRO_0000208558"
FT REGION 1..53
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 4..51
FT /note="RGG-box 1"
FT REGION 145..244
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 153..222
FT /note="RGG-box 2"
SQ SEQUENCE 244 AA; 24626 MW; ABC59931E20C6CE9 CRC64;
MSFRGGRGGG GGFRGGRGGG GGGGFRGGRG GDRGGGFRGG RGGFGGGGRG GYDQGPPEEV
VLVGVFSHQC QDDIVCNNTS GKIPYFNAPI YFKNKEQVGK IDEIFGSPGE NGFSVTLSQG
VKASSFEPES QLYIDPGKLL PVDRFLPQAG GGRGRGGRGR GGDRGGRGSD RGGRGGFGRG
GGGGFRGGDR GGFGGGRGGF RGGDRGGFRG GRGGDFGGRG RGDFKRSYDG GSFGGQNNKR
TKFE
