ID   GAR1_CANGA              Reviewed;         222 AA.
AC   Q6FSB0;
DT   31-AUG-2004, integrated into UniProtKB/Swiss-Prot.
DT   19-JUL-2004, sequence version 1.
DT   25-MAY-2022, entry version 99.
DE   RecName: Full=H/ACA ribonucleoprotein complex subunit GAR1;
DE   AltName: Full=snoRNP protein GAR1;
GN   Name=GAR1; OrderedLocusNames=CAGL0H02057g;
OS   Candida glabrata (strain ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL
OS   Y-65) (Yeast) (Torulopsis glabrata).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Saccharomycetaceae; Nakaseomyces;
OC   Nakaseomyces/Candida clade.
OX   NCBI_TaxID=284593;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL Y-65;
RX   PubMed=15229592; DOI=10.1038/nature02579;
RA   Dujon B., Sherman D., Fischer G., Durrens P., Casaregola S., Lafontaine I.,
RA   de Montigny J., Marck C., Neuveglise C., Talla E., Goffard N., Frangeul L.,
RA   Aigle M., Anthouard V., Babour A., Barbe V., Barnay S., Blanchin S.,
RA   Beckerich J.-M., Beyne E., Bleykasten C., Boisrame A., Boyer J.,
RA   Cattolico L., Confanioleri F., de Daruvar A., Despons L., Fabre E.,
RA   Fairhead C., Ferry-Dumazet H., Groppi A., Hantraye F., Hennequin C.,
RA   Jauniaux N., Joyet P., Kachouri R., Kerrest A., Koszul R., Lemaire M.,
RA   Lesur I., Ma L., Muller H., Nicaud J.-M., Nikolski M., Oztas S.,
RA   Ozier-Kalogeropoulos O., Pellenz S., Potier S., Richard G.-F.,
RA   Straub M.-L., Suleau A., Swennen D., Tekaia F., Wesolowski-Louvel M.,
RA   Westhof E., Wirth B., Zeniou-Meyer M., Zivanovic Y., Bolotin-Fukuhara M.,
RA   Thierry A., Bouchier C., Caudron B., Scarpelli C., Gaillardin C.,
RA   Weissenbach J., Wincker P., Souciet J.-L.;
RT   "Genome evolution in yeasts.";
RL   Nature 430:35-44(2004).
CC   -!- FUNCTION: Non-catalytic component of the H/ACA small nucleolar
CC       ribonucleoprotein (H/ACA snoRNP), which catalyzes pseudouridylation of
CC       rRNA and is required for ribosome biogenesis. This involves the
CC       isomerization of uridine such that the ribose is subsequently attached
CC       to C5, instead of the normal N1. Pseudouridine ('psi') residues may
CC       serve to stabilize the conformation of rRNAs. The H/ACA snoRNP complex
CC       also mediates pseudouridylation of other types of RNAs. The H/ACA
CC       snoRNP complex mediates pseudouridylation at position 93 in U2 snRNA.
CC       {ECO:0000250|UniProtKB:P28007}.
CC   -!- SUBUNIT: Component of the small nucleolar ribonucleoprotein particles
CC       containing H/ACA-type snoRNAs (H/ACA snoRNPs).
CC       {ECO:0000250|UniProtKB:P28007}.
CC   -!- SUBCELLULAR LOCATION: Nucleus, nucleolus
CC       {ECO:0000250|UniProtKB:P28007}.
CC   -!- SIMILARITY: Belongs to the GAR1 family. {ECO:0000305}.
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DR   EMBL; CR380954; CAG59817.1; -; Genomic_DNA.
DR   RefSeq; XP_446884.1; XM_446884.1.
DR   AlphaFoldDB; Q6FSB0; -.
DR   SMR; Q6FSB0; -.
DR   STRING; 5478.XP_446884.1; -.
DR   EnsemblFungi; CAG59817; CAG59817; CAGL0H02057g.
DR   GeneID; 2888567; -.
DR   KEGG; cgr:CAGL0H02057g; -.
DR   CGD; CAL0131932; CAGL0H02057g.
DR   VEuPathDB; FungiDB:CAGL0H02057g; -.
DR   eggNOG; KOG3262; Eukaryota.
DR   HOGENOM; CLU_080002_1_0_1; -.
DR   InParanoid; Q6FSB0; -.
DR   OMA; HSCEGEM; -.
DR   Proteomes; UP000002428; Chromosome H.
DR   GO; GO:0031429; C:box H/ACA snoRNP complex; IEA:EnsemblFungi.
DR   GO; GO:0034513; F:box H/ACA snoRNA binding; IEA:EnsemblFungi.
DR   GO; GO:0000454; P:snoRNA guided rRNA pseudouridine synthesis; IEA:EnsemblFungi.
DR   GO; GO:0031120; P:snRNA pseudouridine synthesis; IEA:EnsemblFungi.
DR   Gene3D; 2.40.10.230; -; 1.
DR   InterPro; IPR038664; Gar1/Naf1_Cbf5-bd_sf.
DR   InterPro; IPR007504; H/ACA_rnp_Gar1/Naf1.
DR   InterPro; IPR009000; Transl_B-barrel_sf.
DR   Pfam; PF04410; Gar1; 1.
DR   SUPFAM; SSF50447; SSF50447; 1.
PE   3: Inferred from homology;
KW   Nucleus; Reference proteome; Repeat; Ribonucleoprotein;
KW   Ribosome biogenesis; RNA-binding; rRNA processing.
FT   CHAIN           1..222
FT                   /note="H/ACA ribonucleoprotein complex subunit GAR1"
FT                   /id="PRO_0000208563"
FT   REGION          1..35
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          4..27
FT                   /note="RGG-box 1"
FT   REGION          124..222
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          148..222
FT                   /note="RGG-box 2"
SQ   SEQUENCE   222 AA;  22530 MW;  83C8B3C2772C4955 CRC64;
     MSFRGGFRGG RGGSRGGFGG RGGARGGRPI QQGPPDTVLE MGEFMHPCEG DVVCRSINTK
     VPYFNAPIYL ENKTQVGKVD EILGPLNEVY FTIKCGEGVQ ATSFKEGDKF YIAPDKLLPI
     ERFIPKPKVA GPPKPKNKKK RSGAPAGRGG ARGGFGGRGG SRGGFGGRGG SRGGFGGRGG
     SRGGFGGRGG SRGGFGGRGG SRGGFGGRGG SRGGFGGRGG RS