GAR1_CHAGB
ID GAR1_CHAGB Reviewed; 210 AA.
AC Q2HH48;
DT 08-APR-2008, integrated into UniProtKB/Swiss-Prot.
DT 21-MAR-2006, sequence version 1.
DT 03-AUG-2022, entry version 64.
DE RecName: Full=H/ACA ribonucleoprotein complex subunit GAR1;
DE AltName: Full=snoRNP protein GAR1;
GN Name=GAR1; ORFNames=CHGG_00456;
OS Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 /
OS NRRL 1970) (Soil fungus).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC Sordariomycetidae; Sordariales; Chaetomiaceae; Chaetomium.
OX NCBI_TaxID=306901;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970;
RX PubMed=25720678; DOI=10.1128/genomea.00021-15;
RA Cuomo C.A., Untereiner W.A., Ma L.-J., Grabherr M., Birren B.W.;
RT "Draft genome sequence of the cellulolytic fungus Chaetomium globosum.";
RL Genome Announc. 3:E0002115-E0002115(2015).
CC -!- FUNCTION: Non-catalytic component of the H/ACA small nucleolar
CC ribonucleoprotein (H/ACA snoRNP), which catalyzes pseudouridylation of
CC rRNA and is required for ribosome biogenesis. This involves the
CC isomerization of uridine such that the ribose is subsequently attached
CC to C5, instead of the normal N1. Pseudouridine ('psi') residues may
CC serve to stabilize the conformation of rRNAs. The H/ACA snoRNP complex
CC also mediates pseudouridylation of other types of RNAs. The H/ACA
CC snoRNP complex mediates pseudouridylation at position 93 in U2 snRNA.
CC {ECO:0000250|UniProtKB:P28007}.
CC -!- SUBUNIT: Component of the small nucleolar ribonucleoprotein particles
CC containing H/ACA-type snoRNAs (H/ACA snoRNPs).
CC {ECO:0000250|UniProtKB:P28007}.
CC -!- SUBCELLULAR LOCATION: Nucleus, nucleolus
CC {ECO:0000250|UniProtKB:P28007}.
CC -!- SIMILARITY: Belongs to the GAR1 family. {ECO:0000305}.
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DR EMBL; CH408029; EAQ92221.1; -; Genomic_DNA.
DR RefSeq; XP_001219677.1; XM_001219676.1.
DR AlphaFoldDB; Q2HH48; -.
DR SMR; Q2HH48; -.
DR STRING; 38033.XP_001219677.1; -.
DR PRIDE; Q2HH48; -.
DR EnsemblFungi; EAQ92221; EAQ92221; CHGG_00456.
DR GeneID; 4387576; -.
DR eggNOG; KOG3262; Eukaryota.
DR HOGENOM; CLU_080002_1_0_1; -.
DR InParanoid; Q2HH48; -.
DR OMA; HSCEGEM; -.
DR OrthoDB; 1530008at2759; -.
DR Proteomes; UP000001056; Unassembled WGS sequence.
DR GO; GO:0005730; C:nucleolus; IEA:UniProtKB-SubCell.
DR GO; GO:0003723; F:RNA binding; IEA:UniProtKB-KW.
DR GO; GO:0001522; P:pseudouridine synthesis; IEA:InterPro.
DR GO; GO:0006364; P:rRNA processing; IEA:UniProtKB-KW.
DR Gene3D; 2.40.10.230; -; 1.
DR InterPro; IPR038664; Gar1/Naf1_Cbf5-bd_sf.
DR InterPro; IPR007504; H/ACA_rnp_Gar1/Naf1.
DR InterPro; IPR009000; Transl_B-barrel_sf.
DR Pfam; PF04410; Gar1; 1.
DR SUPFAM; SSF50447; SSF50447; 1.
PE 3: Inferred from homology;
KW Nucleus; Reference proteome; Repeat; Ribonucleoprotein;
KW Ribosome biogenesis; RNA-binding; rRNA processing.
FT CHAIN 1..210
FT /note="H/ACA ribonucleoprotein complex subunit GAR1"
FT /id="PRO_0000327525"
FT REGION 1..32
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 4..25
FT /note="RGG-box 1"
FT REGION 121..210
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 141..205
FT /note="RGG-box 2"
SQ SEQUENCE 210 AA; 21140 MW; 67B45A72FAD44A2D CRC64;
MSFRGAPRGR GGGGFGGGRG GGRGGFQQRD MGPPATVLEM GKFIHACEGE MVIESTNPKV
PHFNAPIYLE NKTAVGKVDE VLGPINQVYF TIKPSEGIQA TSFKYGDKFY IAGEKLLPLE
RFLPKPKPPP GTVSKVKKPS RGGAARGGRG GPGGGFSRGG GRGGGRGGFG GSRGGGGFGG
GFGGGRGGAP RGGRGGFSRG GGRGGGRGRF
