ID   GAR1_COCIM              Reviewed;         203 AA.
AC   Q1E6M1; A0A0D6K9Q3; J3KKB4;
DT   08-APR-2008, integrated into UniProtKB/Swiss-Prot.
DT   11-JUL-2006, sequence version 1.
DT   25-MAY-2022, entry version 75.
DE   RecName: Full=H/ACA ribonucleoprotein complex subunit GAR1;
DE   AltName: Full=snoRNP protein GAR1;
GN   Name=GAR1; ORFNames=CIMG_01792;
OS   Coccidioides immitis (strain RS) (Valley fever fungus).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC   Eurotiomycetidae; Onygenales; Onygenaceae; Coccidioides.
OX   NCBI_TaxID=246410;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=RS;
RX   PubMed=19717792; DOI=10.1101/gr.087551.108;
RA   Sharpton T.J., Stajich J.E., Rounsley S.D., Gardner M.J., Wortman J.R.,
RA   Jordar V.S., Maiti R., Kodira C.D., Neafsey D.E., Zeng Q., Hung C.-Y.,
RA   McMahan C., Muszewska A., Grynberg M., Mandel M.A., Kellner E.M.,
RA   Barker B.M., Galgiani J.N., Orbach M.J., Kirkland T.N., Cole G.T.,
RA   Henn M.R., Birren B.W., Taylor J.W.;
RT   "Comparative genomic analyses of the human fungal pathogens Coccidioides
RT   and their relatives.";
RL   Genome Res. 19:1722-1731(2009).
RN   [2]
RP   GENOME REANNOTATION.
RC   STRAIN=RS;
RX   PubMed=20516208; DOI=10.1101/gr.103911.109;
RA   Neafsey D.E., Barker B.M., Sharpton T.J., Stajich J.E., Park D.J.,
RA   Whiston E., Hung C.-Y., McMahan C., White J., Sykes S., Heiman D.,
RA   Young S., Zeng Q., Abouelleil A., Aftuck L., Bessette D., Brown A.,
RA   FitzGerald M., Lui A., Macdonald J.P., Priest M., Orbach M.J.,
RA   Galgiani J.N., Kirkland T.N., Cole G.T., Birren B.W., Henn M.R.,
RA   Taylor J.W., Rounsley S.D.;
RT   "Population genomic sequencing of Coccidioides fungi reveals recent
RT   hybridization and transposon control.";
RL   Genome Res. 20:938-946(2010).
CC   -!- FUNCTION: Non-catalytic component of the H/ACA small nucleolar
CC       ribonucleoprotein (H/ACA snoRNP), which catalyzes pseudouridylation of
CC       rRNA and is required for ribosome biogenesis. This involves the
CC       isomerization of uridine such that the ribose is subsequently attached
CC       to C5, instead of the normal N1. Pseudouridine ('psi') residues may
CC       serve to stabilize the conformation of rRNAs. The H/ACA snoRNP complex
CC       also mediates pseudouridylation of other types of RNAs. The H/ACA
CC       snoRNP complex mediates pseudouridylation at position 93 in U2 snRNA.
CC       {ECO:0000250|UniProtKB:P28007}.
CC   -!- SUBUNIT: Component of the small nucleolar ribonucleoprotein particles
CC       containing H/ACA-type snoRNAs (H/ACA snoRNPs).
CC       {ECO:0000250|UniProtKB:P28007}.
CC   -!- SUBCELLULAR LOCATION: Nucleus, nucleolus
CC       {ECO:0000250|UniProtKB:P28007}.
CC   -!- SIMILARITY: Belongs to the GAR1 family. {ECO:0000305}.
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DR   EMBL; GG704911; EAS36438.1; -; Genomic_DNA.
DR   RefSeq; XP_001248021.1; XM_001248020.2.
DR   AlphaFoldDB; Q1E6M1; -.
DR   SMR; Q1E6M1; -.
DR   STRING; 246410.Q1E6M1; -.
DR   EnsemblFungi; EAS36438; EAS36438; CIMG_01792.
DR   GeneID; 4566723; -.
DR   KEGG; cim:CIMG_01792; -.
DR   VEuPathDB; FungiDB:CIMG_01792; -.
DR   InParanoid; Q1E6M1; -.
DR   OMA; HSCEGEM; -.
DR   OrthoDB; 1530008at2759; -.
DR   Proteomes; UP000001261; Unassembled WGS sequence.
DR   GO; GO:0005730; C:nucleolus; IEA:UniProtKB-SubCell.
DR   GO; GO:0003723; F:RNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0001522; P:pseudouridine synthesis; IEA:InterPro.
DR   GO; GO:0006364; P:rRNA processing; IEA:UniProtKB-KW.
DR   Gene3D; 2.40.10.230; -; 1.
DR   InterPro; IPR038664; Gar1/Naf1_Cbf5-bd_sf.
DR   InterPro; IPR007504; H/ACA_rnp_Gar1/Naf1.
DR   InterPro; IPR009000; Transl_B-barrel_sf.
DR   Pfam; PF04410; Gar1; 1.
DR   SUPFAM; SSF50447; SSF50447; 1.
PE   3: Inferred from homology;
KW   Nucleus; Reference proteome; Repeat; Ribonucleoprotein;
KW   Ribosome biogenesis; RNA-binding; rRNA processing.
FT   CHAIN           1..203
FT                   /note="H/ACA ribonucleoprotein complex subunit GAR1"
FT                   /id="PRO_0000327526"
FT   REGION          1..32
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          4..29
FT                   /note="RGG-box 1"
FT   REGION          124..203
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          146..198
FT                   /note="RGG-box 2"
SQ   SEQUENCE   203 AA;  20653 MW;  F3EA1D6BBC7F54C4 CRC64;
     MASRGGSRGR GFGTGANRGG FSARGGRGGM QQSFGPPTTV LEMGSFMHAC EGEMVCESIN
     PKIPYFNAPI YLENKTPVGK VDEVLGPINQ VYFTIKPQEG IVATSFKPGD KFYIGGDKLL
     PLEKFLPKPK PPPGVSKPKK AAGTGRGGVR GGRGGARGGR GAPRGRGGFG GRGGGGARGG
     RGGGFSSRGG PRGGSRGGFR GRG