ID   GAR1_CRYNJ              Reviewed;         203 AA.
AC   P0CN78; Q55MQ5; Q5KB30;
DT   28-JUN-2011, integrated into UniProtKB/Swiss-Prot.
DT   28-JUN-2011, sequence version 1.
DT   25-MAY-2022, entry version 53.
DE   RecName: Full=H/ACA ribonucleoprotein complex subunit GAR1;
DE   AltName: Full=snoRNP protein GAR1;
GN   Name=GAR1; OrderedLocusNames=CNI03970;
OS   Cryptococcus neoformans var. neoformans serotype D (strain JEC21 / ATCC
OS   MYA-565) (Filobasidiella neoformans).
OC   Eukaryota; Fungi; Dikarya; Basidiomycota; Agaricomycotina; Tremellomycetes;
OC   Tremellales; Cryptococcaceae; Cryptococcus;
OC   Cryptococcus neoformans species complex.
OX   NCBI_TaxID=214684;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=JEC21 / ATCC MYA-565;
RX   PubMed=15653466; DOI=10.1126/science.1103773;
RA   Loftus B.J., Fung E., Roncaglia P., Rowley D., Amedeo P., Bruno D.,
RA   Vamathevan J., Miranda M., Anderson I.J., Fraser J.A., Allen J.E.,
RA   Bosdet I.E., Brent M.R., Chiu R., Doering T.L., Donlin M.J., D'Souza C.A.,
RA   Fox D.S., Grinberg V., Fu J., Fukushima M., Haas B.J., Huang J.C.,
RA   Janbon G., Jones S.J.M., Koo H.L., Krzywinski M.I., Kwon-Chung K.J.,
RA   Lengeler K.B., Maiti R., Marra M.A., Marra R.E., Mathewson C.A.,
RA   Mitchell T.G., Pertea M., Riggs F.R., Salzberg S.L., Schein J.E.,
RA   Shvartsbeyn A., Shin H., Shumway M., Specht C.A., Suh B.B., Tenney A.,
RA   Utterback T.R., Wickes B.L., Wortman J.R., Wye N.H., Kronstad J.W.,
RA   Lodge J.K., Heitman J., Davis R.W., Fraser C.M., Hyman R.W.;
RT   "The genome of the basidiomycetous yeast and human pathogen Cryptococcus
RT   neoformans.";
RL   Science 307:1321-1324(2005).
CC   -!- FUNCTION: Non-catalytic component of the H/ACA small nucleolar
CC       ribonucleoprotein (H/ACA snoRNP), which catalyzes pseudouridylation of
CC       rRNA and is required for ribosome biogenesis. This involves the
CC       isomerization of uridine such that the ribose is subsequently attached
CC       to C5, instead of the normal N1. Pseudouridine ('psi') residues may
CC       serve to stabilize the conformation of rRNAs. The H/ACA snoRNP complex
CC       also mediates pseudouridylation of other types of RNAs. The H/ACA
CC       snoRNP complex mediates pseudouridylation at position 93 in U2 snRNA.
CC       {ECO:0000250|UniProtKB:P28007}.
CC   -!- SUBUNIT: Component of the small nucleolar ribonucleoprotein particles
CC       containing H/ACA-type snoRNAs (H/ACA snoRNPs).
CC       {ECO:0000250|UniProtKB:P28007}.
CC   -!- SUBCELLULAR LOCATION: Nucleus, nucleolus
CC       {ECO:0000250|UniProtKB:P28007}.
CC   -!- SIMILARITY: Belongs to the GAR1 family. {ECO:0000305}.
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DR   EMBL; AE017349; AAW45593.1; -; Genomic_DNA.
DR   RefSeq; XP_572900.1; XM_572900.1.
DR   AlphaFoldDB; P0CN78; -.
DR   SMR; P0CN78; -.
DR   STRING; 5207.AAW45593; -.
DR   PaxDb; P0CN78; -.
DR   EnsemblFungi; AAW45593; AAW45593; CNI03970.
DR   eggNOG; KOG3262; Eukaryota.
DR   HOGENOM; CLU_080002_1_0_1; -.
DR   InParanoid; P0CN78; -.
DR   OMA; HSCEGEM; -.
DR   OrthoDB; 1530008at2759; -.
DR   Proteomes; UP000002149; Chromosome 9.
DR   GO; GO:0031429; C:box H/ACA snoRNP complex; IBA:GO_Central.
DR   GO; GO:0034513; F:box H/ACA snoRNA binding; IBA:GO_Central.
DR   GO; GO:0000454; P:snoRNA guided rRNA pseudouridine synthesis; IBA:GO_Central.
DR   GO; GO:0031120; P:snRNA pseudouridine synthesis; IEA:EnsemblFungi.
DR   Gene3D; 2.40.10.230; -; 1.
DR   InterPro; IPR038664; Gar1/Naf1_Cbf5-bd_sf.
DR   InterPro; IPR007504; H/ACA_rnp_Gar1/Naf1.
DR   InterPro; IPR009000; Transl_B-barrel_sf.
DR   Pfam; PF04410; Gar1; 1.
DR   SUPFAM; SSF50447; SSF50447; 1.
PE   3: Inferred from homology;
KW   Nucleus; Reference proteome; Repeat; Ribonucleoprotein;
KW   Ribosome biogenesis; RNA-binding; rRNA processing.
FT   CHAIN           1..203
FT                   /note="H/ACA ribonucleoprotein complex subunit GAR1"
FT                   /id="PRO_0000327527"
FT   REGION          1..38
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          4..28
FT                   /note="RGG-box 1"
FT   REGION          131..203
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          150..202
FT                   /note="RGG-box 2"
SQ   SEQUENCE   203 AA;  20819 MW;  43352D9FD1EC406D CRC64;
     MSGRGFSRGG GGGFRGGARG GRGGGRGGFQ QRDMGPPDTV LEIGSFQHDV ESEMLCSLTA
     PTKIPYFNAP IYLQNKTQIG KVDEILGPIN EVYFTVKMEQ GMLASSFKKE DKVYISGEKL
     LPIERFLPKP KVAGGKERGA QGGRGAPRGR GGAGSRGGRG GFSSRGGPGG RGGARGGAGG
     RGGFSSRGGG APRGRGGFRG RGQ