ID   GAR1_DANRE              Reviewed;         226 AA.
AC   Q7ZVE0;
DT   31-AUG-2004, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-2003, sequence version 1.
DT   03-AUG-2022, entry version 90.
DE   RecName: Full=H/ACA ribonucleoprotein complex subunit 1;
DE   AltName: Full=Nucleolar protein family A member 1;
DE   AltName: Full=snoRNP protein GAR1;
GN   Name=gar1; Synonyms=nola1; ORFNames=zgc:56086;
OS   Danio rerio (Zebrafish) (Brachydanio rerio).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC   Danionidae; Danioninae; Danio.
OX   NCBI_TaxID=7955;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RG   NIH - Zebrafish Gene Collection (ZGC) project;
RL   Submitted (JAN-2003) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Required for ribosome biogenesis. Part of a complex which
CC       catalyzes pseudouridylation of rRNA. This involves the isomerization of
CC       uridine such that the ribose is subsequently attached to C5, instead of
CC       the normal N1. Pseudouridine ('psi') residues may serve to stabilize
CC       the conformation of rRNAs (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Component of the small nucleolar ribonucleoprotein particle
CC       containing H/ACA-type snoRNAs (H/ACA snoRNPs) (By similarity).
CC       Component of the telomerase holoenzyme complex (By similarity).
CC       {ECO:0000250|UniProtKB:Q9NY12}.
CC   -!- SUBCELLULAR LOCATION: Nucleus, nucleolus {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the GAR1 family. {ECO:0000305}.
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DR   EMBL; BC045900; AAH45900.1; -; mRNA.
DR   AlphaFoldDB; Q7ZVE0; -.
DR   SMR; Q7ZVE0; -.
DR   STRING; 7955.ENSDARP00000101401; -.
DR   PaxDb; Q7ZVE0; -.
DR   ZFIN; ZDB-GENE-040426-893; gar1.
DR   eggNOG; KOG3262; Eukaryota.
DR   InParanoid; Q7ZVE0; -.
DR   Reactome; R-DRE-171319; Telomere Extension By Telomerase.
DR   PRO; PR:Q7ZVE0; -.
DR   Proteomes; UP000000437; Genome assembly.
DR   Proteomes; UP000814640; Unplaced.
DR   GO; GO:0031429; C:box H/ACA snoRNP complex; IBA:GO_Central.
DR   GO; GO:0005697; C:telomerase holoenzyme complex; ISS:UniProtKB.
DR   GO; GO:0034513; F:box H/ACA snoRNA binding; IBA:GO_Central.
DR   GO; GO:0060216; P:definitive hemopoiesis; IMP:ZFIN.
DR   GO; GO:0006364; P:rRNA processing; IMP:ZFIN.
DR   GO; GO:0000454; P:snoRNA guided rRNA pseudouridine synthesis; IBA:GO_Central.
DR   GO; GO:0007004; P:telomere maintenance via telomerase; ISS:UniProtKB.
DR   Gene3D; 2.40.10.230; -; 1.
DR   InterPro; IPR038664; Gar1/Naf1_Cbf5-bd_sf.
DR   InterPro; IPR007504; H/ACA_rnp_Gar1/Naf1.
DR   InterPro; IPR009000; Transl_B-barrel_sf.
DR   Pfam; PF04410; Gar1; 1.
DR   SUPFAM; SSF50447; SSF50447; 1.
PE   2: Evidence at transcript level;
KW   Nucleus; Reference proteome; Repeat; Ribonucleoprotein;
KW   Ribosome biogenesis; RNA-binding; rRNA processing.
FT   CHAIN           1..226
FT                   /note="H/ACA ribonucleoprotein complex subunit 1"
FT                   /id="PRO_0000208555"
FT   REGION          1..30
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          4..51
FT                   /note="RGG-box 1"
FT   REGION          150..226
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          163..226
FT                   /note="RGG-box 2"
SQ   SEQUENCE   226 AA;  22813 MW;  DA107232EABE842B CRC64;
     MSFRGGGGGR GGGFNRGGGG GRGGGFGGGR GGGFGGGRGG GFGGGRGGRG GFNRNQDYGP
     PEYVVALGEF MHPCEDEIVC KCVTEENKVP YFNAPVYLEN KEQIGKVDEI FGQLRDFYFS
     VKLSDNMKAS SFKKLQKFYI DPMKLLPLQR FLPRPPGEKG PPRGGRGGGG GRGGRGGGFR
     GGRGANGGGR GGFGGRGGGF GGRGGGGGGF RGGRGGGGGR GFRGGR