GAR1_DEBHA
ID GAR1_DEBHA Reviewed; 215 AA.
AC Q6BVF9;
DT 08-APR-2008, integrated into UniProtKB/Swiss-Prot.
DT 16-AUG-2004, sequence version 1.
DT 25-MAY-2022, entry version 93.
DE RecName: Full=H/ACA ribonucleoprotein complex subunit GAR1;
DE AltName: Full=snoRNP protein GAR1;
GN Name=GAR1; OrderedLocusNames=DEHA2C02992g;
OS Debaryomyces hansenii (strain ATCC 36239 / CBS 767 / BCRC 21394 / JCM 1990
OS / NBRC 0083 / IGC 2968) (Yeast) (Torulaspora hansenii).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Debaryomycetaceae; Debaryomyces.
OX NCBI_TaxID=284592;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 36239 / CBS 767 / BCRC 21394 / JCM 1990 / NBRC 0083 / IGC 2968;
RX PubMed=15229592; DOI=10.1038/nature02579;
RA Dujon B., Sherman D., Fischer G., Durrens P., Casaregola S., Lafontaine I.,
RA de Montigny J., Marck C., Neuveglise C., Talla E., Goffard N., Frangeul L.,
RA Aigle M., Anthouard V., Babour A., Barbe V., Barnay S., Blanchin S.,
RA Beckerich J.-M., Beyne E., Bleykasten C., Boisrame A., Boyer J.,
RA Cattolico L., Confanioleri F., de Daruvar A., Despons L., Fabre E.,
RA Fairhead C., Ferry-Dumazet H., Groppi A., Hantraye F., Hennequin C.,
RA Jauniaux N., Joyet P., Kachouri R., Kerrest A., Koszul R., Lemaire M.,
RA Lesur I., Ma L., Muller H., Nicaud J.-M., Nikolski M., Oztas S.,
RA Ozier-Kalogeropoulos O., Pellenz S., Potier S., Richard G.-F.,
RA Straub M.-L., Suleau A., Swennen D., Tekaia F., Wesolowski-Louvel M.,
RA Westhof E., Wirth B., Zeniou-Meyer M., Zivanovic Y., Bolotin-Fukuhara M.,
RA Thierry A., Bouchier C., Caudron B., Scarpelli C., Gaillardin C.,
RA Weissenbach J., Wincker P., Souciet J.-L.;
RT "Genome evolution in yeasts.";
RL Nature 430:35-44(2004).
CC -!- FUNCTION: Non-catalytic component of the H/ACA small nucleolar
CC ribonucleoprotein (H/ACA snoRNP), which catalyzes pseudouridylation of
CC rRNA and is required for ribosome biogenesis. This involves the
CC isomerization of uridine such that the ribose is subsequently attached
CC to C5, instead of the normal N1. Pseudouridine ('psi') residues may
CC serve to stabilize the conformation of rRNAs. The H/ACA snoRNP complex
CC also mediates pseudouridylation of other types of RNAs. The H/ACA
CC snoRNP complex mediates pseudouridylation at position 93 in U2 snRNA.
CC {ECO:0000250|UniProtKB:P28007}.
CC -!- SUBUNIT: Component of the small nucleolar ribonucleoprotein particles
CC containing H/ACA-type snoRNAs (H/ACA snoRNPs).
CC {ECO:0000250|UniProtKB:P28007}.
CC -!- SUBCELLULAR LOCATION: Nucleus, nucleolus
CC {ECO:0000250|UniProtKB:P28007}.
CC -!- SIMILARITY: Belongs to the GAR1 family. {ECO:0000305}.
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DR EMBL; CR382135; CAG85850.1; -; Genomic_DNA.
DR RefSeq; XP_457810.1; XM_457810.1.
DR AlphaFoldDB; Q6BVF9; -.
DR SMR; Q6BVF9; -.
DR STRING; 4959.XP_457810.1; -.
DR EnsemblFungi; CAG85850; CAG85850; DEHA2C02992g.
DR GeneID; 2900261; -.
DR KEGG; dha:DEHA2C02992g; -.
DR VEuPathDB; FungiDB:DEHA2C02992g; -.
DR eggNOG; KOG3262; Eukaryota.
DR HOGENOM; CLU_080002_1_0_1; -.
DR InParanoid; Q6BVF9; -.
DR OMA; HSCEGEM; -.
DR OrthoDB; 1530008at2759; -.
DR Proteomes; UP000000599; Chromosome C.
DR GO; GO:0005730; C:nucleolus; IEA:UniProtKB-SubCell.
DR GO; GO:0003723; F:RNA binding; IEA:UniProtKB-KW.
DR GO; GO:0001522; P:pseudouridine synthesis; IEA:InterPro.
DR GO; GO:0006364; P:rRNA processing; IEA:UniProtKB-KW.
DR Gene3D; 2.40.10.230; -; 1.
DR InterPro; IPR038664; Gar1/Naf1_Cbf5-bd_sf.
DR InterPro; IPR007504; H/ACA_rnp_Gar1/Naf1.
DR InterPro; IPR009000; Transl_B-barrel_sf.
DR Pfam; PF04410; Gar1; 1.
DR SUPFAM; SSF50447; SSF50447; 1.
PE 3: Inferred from homology;
KW Nucleus; Reference proteome; Repeat; Ribonucleoprotein;
KW Ribosome biogenesis; RNA-binding; rRNA processing.
FT CHAIN 1..215
FT /note="H/ACA ribonucleoprotein complex subunit GAR1"
FT /id="PRO_0000327528"
FT REGION 1..26
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 5..17
FT /note="RGG-box 1"
FT REGION 117..215
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 135..213
FT /note="RGG-box 2"
SQ SEQUENCE 215 AA; 22109 MW; 2EB2753715F27FFB CRC64;
MNRGRGGFRG GRGGRTGPSQ FQQGPPDTVL EMGAFMQSCE GDIVCRSINV KIPYFNAPIY
LENKTQVGKV DEILGPVNEV FFTIKPSEGV QADSFKDGDK FYIGPDKLLP LERFLPKPKE
FGTKPKKKSA GGAGRGGFGG RGGARGGRGG FGGRGGSRGG FGDRGGRGGS RGGFGGRGGS
RGGFGDRGGF GGRGGSRGGF GDRGGRGGGF RGGRF
