GAR1_DICDI
ID GAR1_DICDI Reviewed; 230 AA.
AC Q54XE6;
DT 08-APR-2008, integrated into UniProtKB/Swiss-Prot.
DT 24-MAY-2005, sequence version 1.
DT 25-MAY-2022, entry version 89.
DE RecName: Full=Probable H/ACA ribonucleoprotein complex subunit 1;
DE AltName: Full=Nucleolar protein family A member 1;
DE AltName: Full=snoRNP protein GAR1;
GN Name=gar1; Synonyms=nola1; ORFNames=DDB_G0279013;
OS Dictyostelium discoideum (Slime mold).
OC Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales;
OC Dictyosteliaceae; Dictyostelium.
OX NCBI_TaxID=44689;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AX4;
RX PubMed=15875012; DOI=10.1038/nature03481;
RA Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R.,
RA Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B.,
RA Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T.,
RA Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P., Pilcher K., Chen G.,
RA Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N.,
RA Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E.,
RA Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N.,
RA Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D.,
RA Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T.,
RA Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D.,
RA Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A.,
RA Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M.,
RA Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A.,
RA Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y.,
RA Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C.,
RA Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R.,
RA Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.;
RT "The genome of the social amoeba Dictyostelium discoideum.";
RL Nature 435:43-57(2005).
CC -!- FUNCTION: Required for ribosome biogenesis. Part of a complex which
CC catalyzes pseudouridylation of rRNA. This involves the isomerization of
CC uridine such that the ribose is subsequently attached to C5, instead of
CC the normal N1. Pseudouridine ('psi') residues may serve to stabilize
CC the conformation of rRNAs (By similarity). {ECO:0000250}.
CC -!- SUBUNIT: Component of the small nucleolar ribonucleoprotein particles
CC containing H/ACA-type snoRNAs (H/ACA snoRNPs). {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Nucleus, nucleolus {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the GAR1 family. {ECO:0000305}.
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DR EMBL; AAFI02000026; EAL67928.1; -; Genomic_DNA.
DR RefSeq; XP_641906.1; XM_636814.1.
DR AlphaFoldDB; Q54XE6; -.
DR SMR; Q54XE6; -.
DR STRING; 44689.DDB0235390; -.
DR PaxDb; Q54XE6; -.
DR EnsemblProtists; EAL67928; EAL67928; DDB_G0279013.
DR GeneID; 8621829; -.
DR KEGG; ddi:DDB_G0279013; -.
DR dictyBase; DDB_G0279013; nola1.
DR eggNOG; KOG3262; Eukaryota.
DR HOGENOM; CLU_080002_0_0_1; -.
DR InParanoid; Q54XE6; -.
DR OMA; VCKVDIQ; -.
DR PRO; PR:Q54XE6; -.
DR Proteomes; UP000002195; Chromosome 3.
DR GO; GO:0031429; C:box H/ACA snoRNP complex; IBA:GO_Central.
DR GO; GO:0034513; F:box H/ACA snoRNA binding; IBA:GO_Central.
DR GO; GO:0000454; P:snoRNA guided rRNA pseudouridine synthesis; IBA:GO_Central.
DR Gene3D; 2.40.10.230; -; 1.
DR InterPro; IPR038664; Gar1/Naf1_Cbf5-bd_sf.
DR InterPro; IPR007504; H/ACA_rnp_Gar1/Naf1.
DR InterPro; IPR009000; Transl_B-barrel_sf.
DR Pfam; PF04410; Gar1; 1.
DR SUPFAM; SSF50447; SSF50447; 1.
PE 3: Inferred from homology;
KW Nucleus; Reference proteome; Repeat; Ribonucleoprotein;
KW Ribosome biogenesis; RNA-binding; rRNA processing.
FT CHAIN 1..230
FT /note="Probable H/ACA ribonucleoprotein complex subunit 1"
FT /id="PRO_0000327523"
FT REGION 1..53
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 4..56
FT /note="RGG-box 1"
FT REGION 158..230
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 169..229
FT /note="RGG-box 2"
SQ SEQUENCE 230 AA; 22373 MW; B22343A1C4078AA3 CRC64;
MSFRGGRGGF GGGDRGGRGG GRGGFGGGDR GGRGGFGGGR GGGRGGFGGD RGDRGGYASG
ENIEIGVFSH VCEEQIVCKL TATEQVPKFN CKVLSSSKNT IGSVDEIFGP INKVFFSVKL
DSGVQATSFK ENDKIFVDSN SVLPIKIFLE EPKPIAKVPK TPGAGGAGRG GRGGARGGFG
GGRGGGAGRG GFGGGRGGSR GGFGGGRGGG SGFGGRGGSR GGRGGGRGGF
