GAR1_DROME
ID GAR1_DROME Reviewed; 237 AA.
AC Q7KVQ0; Q24345; Q86R95; Q9W2L8;
DT 05-JUL-2005, integrated into UniProtKB/Swiss-Prot.
DT 05-JUL-2004, sequence version 1.
DT 03-AUG-2022, entry version 139.
DE RecName: Full=Probable H/ACA ribonucleoprotein complex subunit 1;
DE AltName: Full=GCR 101 snRNP;
DE AltName: Full=Nucleolar protein family A member 1;
GN ORFNames=CG4038;
OS Drosophila melanogaster (Fruit fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC Drosophilidae; Drosophila; Sophophora.
OX NCBI_TaxID=7227;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RA Parchment C., Hughes D.M., Lloyd P., Flavell A.J.;
RT "A variety of different glycine repeats in Drosophila gene.";
RL Submitted (JUL-1994) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Berkeley;
RX PubMed=10731132; DOI=10.1126/science.287.5461.2185;
RA Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D.,
RA Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F.,
RA George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N.,
RA Sutton G.G., Wortman J.R., Yandell M.D., Zhang Q., Chen L.X., Brandon R.C.,
RA Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C.,
RA Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A.,
RA An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A.,
RA Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V.,
RA Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J.,
RA Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E.,
RA Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B.,
RA Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I.,
RA Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C.,
RA Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S.,
RA Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M.,
RA Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M.,
RA Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D.,
RA Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F.,
RA Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D.,
RA Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A.,
RA Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C.,
RA McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C.,
RA Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L.,
RA Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R.,
RA Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V.,
RA Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F.,
RA Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J.,
RA Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R.,
RA Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y.,
RA Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T.,
RA Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S.,
RA Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W.,
RA Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M.,
RA Venter J.C.;
RT "The genome sequence of Drosophila melanogaster.";
RL Science 287:2185-2195(2000).
RN [3]
RP GENOME REANNOTATION.
RC STRAIN=Berkeley;
RX PubMed=12537572; DOI=10.1186/gb-2002-3-12-research0083;
RA Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S.,
RA Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E.,
RA Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P.,
RA Bettencourt B.R., Celniker S.E., de Grey A.D.N.J., Drysdale R.A.,
RA Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., Stapleton M.,
RA Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., Lewis S.E.;
RT "Annotation of the Drosophila melanogaster euchromatic genome: a systematic
RT review.";
RL Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=Berkeley; TISSUE=Embryo;
RX PubMed=12537569; DOI=10.1186/gb-2002-3-12-research0080;
RA Stapleton M., Carlson J.W., Brokstein P., Yu C., Champe M., George R.A.,
RA Guarin H., Kronmiller B., Pacleb J.M., Park S., Wan K.H., Rubin G.M.,
RA Celniker S.E.;
RT "A Drosophila full-length cDNA resource.";
RL Genome Biol. 3:RESEARCH0080.1-RESEARCH0080.8(2002).
CC -!- FUNCTION: Required for ribosome biogenesis. Part of a complex which
CC catalyzes pseudouridylation of rRNA. This involves the isomerization of
CC uridine such that the ribose is subsequently attached to C5, instead of
CC the normal N1. Pseudouridine ('psi') residues may serve to stabilize
CC the conformation of rRNAs (By similarity). {ECO:0000250}.
CC -!- SUBUNIT: Component of the small nucleolar ribonucleoprotein particle
CC containing H/ACA-type snoRNAs (H/ACA snoRNPs). {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Nucleus, nucleolus {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the GAR1 family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAO39496.1; Type=Frameshift; Evidence={ECO:0000305};
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DR EMBL; X71975; CAA50795.1; -; mRNA.
DR EMBL; AE013599; AAF46672.1; -; Genomic_DNA.
DR EMBL; AY075501; AAO39496.1; ALT_FRAME; mRNA.
DR PIR; S49193; S49193.
DR RefSeq; NP_477043.1; NM_057695.4.
DR AlphaFoldDB; Q7KVQ0; -.
DR SMR; Q7KVQ0; -.
DR BioGRID; 63034; 18.
DR IntAct; Q7KVQ0; 16.
DR STRING; 7227.FBpp0071562; -.
DR PaxDb; Q7KVQ0; -.
DR PRIDE; Q7KVQ0; -.
DR DNASU; 37397; -.
DR EnsemblMetazoa; FBtr0071639; FBpp0071562; FBgn0011824.
DR GeneID; 37397; -.
DR KEGG; dme:Dmel_CG4038; -.
DR FlyBase; FBgn0011824; CG4038.
DR VEuPathDB; VectorBase:FBgn0011824; -.
DR eggNOG; KOG3262; Eukaryota.
DR GeneTree; ENSGT00730000111223; -.
DR HOGENOM; CLU_080002_0_1_1; -.
DR InParanoid; Q7KVQ0; -.
DR OMA; VCKVDIQ; -.
DR OrthoDB; 1530008at2759; -.
DR PhylomeDB; Q7KVQ0; -.
DR BioGRID-ORCS; 37397; 0 hits in 1 CRISPR screen.
DR GenomeRNAi; 37397; -.
DR PRO; PR:Q7KVQ0; -.
DR Proteomes; UP000000803; Chromosome 2R.
DR Bgee; FBgn0011824; Expressed in cleaving embryo and 38 other tissues.
DR ExpressionAtlas; Q7KVQ0; baseline and differential.
DR Genevisible; Q7KVQ0; DM.
DR GO; GO:0031429; C:box H/ACA snoRNP complex; IBA:GO_Central.
DR GO; GO:0005730; C:nucleolus; HDA:FlyBase.
DR GO; GO:0005654; C:nucleoplasm; HDA:FlyBase.
DR GO; GO:0005732; C:sno(s)RNA-containing ribonucleoprotein complex; ISS:UniProtKB.
DR GO; GO:0034513; F:box H/ACA snoRNA binding; IBA:GO_Central.
DR GO; GO:0031118; P:rRNA pseudouridine synthesis; ISS:UniProtKB.
DR GO; GO:0000454; P:snoRNA guided rRNA pseudouridine synthesis; IBA:GO_Central.
DR Gene3D; 2.40.10.230; -; 1.
DR InterPro; IPR038664; Gar1/Naf1_Cbf5-bd_sf.
DR InterPro; IPR007504; H/ACA_rnp_Gar1/Naf1.
DR InterPro; IPR009000; Transl_B-barrel_sf.
DR Pfam; PF04410; Gar1; 1.
DR SUPFAM; SSF50447; SSF50447; 1.
PE 2: Evidence at transcript level;
KW Nucleus; Reference proteome; Repeat; Ribonucleoprotein;
KW Ribosome biogenesis; RNA-binding; rRNA processing.
FT CHAIN 1..237
FT /note="Probable H/ACA ribonucleoprotein complex subunit 1"
FT /id="PRO_0000208559"
FT REGION 1..64
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 4..56
FT /note="RGG-box 1"
FT REGION 157..237
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 166..236
FT /note="RGG-box 2"
FT CONFLICT 18..19
FT /note="Missing (in Ref. 1; CAA50795)"
FT /evidence="ECO:0000305"
FT CONFLICT 100
FT /note="F -> V (in Ref. 1; CAA50795)"
FT /evidence="ECO:0000305"
FT CONFLICT 138
FT /note="N -> K (in Ref. 1; CAA50795)"
FT /evidence="ECO:0000305"
FT CONFLICT 186
FT /note="G -> GRGG (in Ref. 1; CAA50795)"
FT /evidence="ECO:0000305"
FT CONFLICT 219
FT /note="G -> GG (in Ref. 1; CAA50795)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 237 AA; 22665 MW; C3FF642FE6B61E8D CRC64;
MGFGKPRGGG GGGGRGFGGG GGGGGRGFGG GGGGRGGGGG RGGGGGFGRG GGGRGGGRGA
FDTGPPERVI PLGNYVYSCQ NDLVCKVDIQ DVPYFNAPIF LENKEQVGKI DEIFGTVRDY
SVSIKLSDNV YANSFKPNQK LFIDPGKLLP IARFLPKPPQ PKGAKKAFTN NRGGGGGGGG
FGGRGGGRGG GGRGGGGGRG GGGFRGGAGR NGGGGGGGGF NRGRGGGGGG GGGRGRW
