ID   GAR1_KLULA              Reviewed;         219 AA.
AC   Q6CJ45;
DT   08-APR-2008, integrated into UniProtKB/Swiss-Prot.
DT   16-AUG-2004, sequence version 1.
DT   25-MAY-2022, entry version 95.
DE   RecName: Full=H/ACA ribonucleoprotein complex subunit GAR1;
DE   AltName: Full=snoRNP protein GAR1;
GN   Name=GAR1; OrderedLocusNames=KLLA0F21604g;
OS   Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 /
OS   NRRL Y-1140 / WM37) (Yeast) (Candida sphaerica).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Saccharomycetaceae; Kluyveromyces.
OX   NCBI_TaxID=284590;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37;
RX   PubMed=15229592; DOI=10.1038/nature02579;
RA   Dujon B., Sherman D., Fischer G., Durrens P., Casaregola S., Lafontaine I.,
RA   de Montigny J., Marck C., Neuveglise C., Talla E., Goffard N., Frangeul L.,
RA   Aigle M., Anthouard V., Babour A., Barbe V., Barnay S., Blanchin S.,
RA   Beckerich J.-M., Beyne E., Bleykasten C., Boisrame A., Boyer J.,
RA   Cattolico L., Confanioleri F., de Daruvar A., Despons L., Fabre E.,
RA   Fairhead C., Ferry-Dumazet H., Groppi A., Hantraye F., Hennequin C.,
RA   Jauniaux N., Joyet P., Kachouri R., Kerrest A., Koszul R., Lemaire M.,
RA   Lesur I., Ma L., Muller H., Nicaud J.-M., Nikolski M., Oztas S.,
RA   Ozier-Kalogeropoulos O., Pellenz S., Potier S., Richard G.-F.,
RA   Straub M.-L., Suleau A., Swennen D., Tekaia F., Wesolowski-Louvel M.,
RA   Westhof E., Wirth B., Zeniou-Meyer M., Zivanovic Y., Bolotin-Fukuhara M.,
RA   Thierry A., Bouchier C., Caudron B., Scarpelli C., Gaillardin C.,
RA   Weissenbach J., Wincker P., Souciet J.-L.;
RT   "Genome evolution in yeasts.";
RL   Nature 430:35-44(2004).
CC   -!- FUNCTION: Non-catalytic component of the H/ACA small nucleolar
CC       ribonucleoprotein (H/ACA snoRNP), which catalyzes pseudouridylation of
CC       rRNA and is required for ribosome biogenesis. This involves the
CC       isomerization of uridine such that the ribose is subsequently attached
CC       to C5, instead of the normal N1. Pseudouridine ('psi') residues may
CC       serve to stabilize the conformation of rRNAs. The H/ACA snoRNP complex
CC       also mediates pseudouridylation of other types of RNAs. The H/ACA
CC       snoRNP complex mediates pseudouridylation at position 93 in U2 snRNA.
CC       {ECO:0000250|UniProtKB:P28007}.
CC   -!- SUBUNIT: Component of the small nucleolar ribonucleoprotein particles
CC       containing H/ACA-type snoRNAs (H/ACA snoRNPs).
CC       {ECO:0000250|UniProtKB:P28007}.
CC   -!- SUBCELLULAR LOCATION: Nucleus, nucleolus
CC       {ECO:0000250|UniProtKB:P28007}.
CC   -!- SIMILARITY: Belongs to the GAR1 family. {ECO:0000305}.
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DR   EMBL; CR382126; CAG98752.1; -; Genomic_DNA.
DR   RefSeq; XP_456044.1; XM_456044.1.
DR   AlphaFoldDB; Q6CJ45; -.
DR   SMR; Q6CJ45; -.
DR   STRING; 28985.XP_456044.1; -.
DR   EnsemblFungi; CAG98752; CAG98752; KLLA0_F21604g.
DR   GeneID; 2895429; -.
DR   KEGG; kla:KLLA0_F21604g; -.
DR   eggNOG; KOG3262; Eukaryota.
DR   HOGENOM; CLU_080002_1_0_1; -.
DR   InParanoid; Q6CJ45; -.
DR   OMA; HSCEGEM; -.
DR   Proteomes; UP000000598; Chromosome F.
DR   GO; GO:0031429; C:box H/ACA snoRNP complex; IEA:EnsemblFungi.
DR   GO; GO:0034513; F:box H/ACA snoRNA binding; IEA:EnsemblFungi.
DR   GO; GO:0000454; P:snoRNA guided rRNA pseudouridine synthesis; IEA:EnsemblFungi.
DR   GO; GO:0031120; P:snRNA pseudouridine synthesis; IEA:EnsemblFungi.
DR   Gene3D; 2.40.10.230; -; 1.
DR   InterPro; IPR038664; Gar1/Naf1_Cbf5-bd_sf.
DR   InterPro; IPR007504; H/ACA_rnp_Gar1/Naf1.
DR   InterPro; IPR009000; Transl_B-barrel_sf.
DR   Pfam; PF04410; Gar1; 1.
DR   SUPFAM; SSF50447; SSF50447; 1.
PE   3: Inferred from homology;
KW   Nucleus; Reference proteome; Repeat; Ribonucleoprotein;
KW   Ribosome biogenesis; RNA-binding; rRNA processing.
FT   CHAIN           1..219
FT                   /note="H/ACA ribonucleoprotein complex subunit GAR1"
FT                   /id="PRO_0000327529"
FT   REGION          1..29
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          4..24
FT                   /note="RGG-box 1"
FT   REGION          120..219
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          143..212
FT                   /note="RGG-box 2"
SQ   SEQUENCE   219 AA;  22169 MW;  ED42CA1F3EF1C5A0 CRC64;
     MSFRGGNRGS RGGFRGNSRG GFGGRAAPQG PPDSVLEMGA FLHPCEGDIV CRSINTKIPY
     FNAPIYLENK TQVGKVDEIL GPLNEVFFTV KCSDGVKAES FSEGDKFYIA PDKLLPIERF
     LPKPKVAGPP KPKRKRSGAP GGRGGFGGGR GGARGGSRGG FGGGRGGSRG GFGGSRGGFS
     GGRGGFSGGS RGGSRGGSRG GFGGSRGGSR GGFGGGRRF