ID   GAR1_XENTR              Reviewed;         218 AA.
AC   Q5RJV1;
DT   05-JUL-2005, integrated into UniProtKB/Swiss-Prot.
DT   21-DEC-2004, sequence version 1.
DT   03-AUG-2022, entry version 91.
DE   RecName: Full=H/ACA ribonucleoprotein complex subunit 1;
DE   AltName: Full=Nucleolar protein family A member 1;
DE   AltName: Full=snoRNP protein GAR1;
GN   Name=gar1; Synonyms=nola1;
OS   Xenopus tropicalis (Western clawed frog) (Silurana tropicalis).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana.
OX   NCBI_TaxID=8364;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Embryo;
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (NOV-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Required for ribosome biogenesis. Part of a complex which
CC       catalyzes pseudouridylation of rRNA. This involves the isomerization of
CC       uridine such that the ribose is subsequently attached to C5, instead of
CC       the normal N1. Pseudouridine ('psi') residues may serve to stabilize
CC       the conformation of rRNAs (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Component of the small nucleolar ribonucleoprotein particle
CC       containing H/ACA-type snoRNAs (H/ACA snoRNPs). Component of the
CC       telomerase holoenzyme complex. {ECO:0000250|UniProtKB:Q9NY12}.
CC   -!- SUBCELLULAR LOCATION: Nucleus, nucleolus {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the GAR1 family. {ECO:0000305}.
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DR   EMBL; BC086493; AAH86493.1; -; mRNA.
DR   RefSeq; NP_001011252.1; NM_001011252.1.
DR   AlphaFoldDB; Q5RJV1; -.
DR   SMR; Q5RJV1; -.
DR   STRING; 8364.ENSXETP00000052038; -.
DR   PaxDb; Q5RJV1; -.
DR   DNASU; 496698; -.
DR   GeneID; 496698; -.
DR   KEGG; xtr:496698; -.
DR   CTD; 54433; -.
DR   Xenbase; XB-GENE-6258514; gar1.
DR   eggNOG; KOG3262; Eukaryota.
DR   HOGENOM; CLU_080002_0_1_1; -.
DR   InParanoid; Q5RJV1; -.
DR   OrthoDB; 1530008at2759; -.
DR   Reactome; R-XTR-171319; Telomere Extension By Telomerase.
DR   Proteomes; UP000008143; Chromosome 1.
DR   Proteomes; UP000790000; Unplaced.
DR   GO; GO:0031429; C:box H/ACA snoRNP complex; IBA:GO_Central.
DR   GO; GO:0005697; C:telomerase holoenzyme complex; ISS:UniProtKB.
DR   GO; GO:0034513; F:box H/ACA snoRNA binding; IBA:GO_Central.
DR   GO; GO:0000454; P:snoRNA guided rRNA pseudouridine synthesis; IBA:GO_Central.
DR   GO; GO:0007004; P:telomere maintenance via telomerase; ISS:UniProtKB.
DR   Gene3D; 2.40.10.230; -; 1.
DR   InterPro; IPR038664; Gar1/Naf1_Cbf5-bd_sf.
DR   InterPro; IPR007504; H/ACA_rnp_Gar1/Naf1.
DR   InterPro; IPR009000; Transl_B-barrel_sf.
DR   Pfam; PF04410; Gar1; 1.
DR   SUPFAM; SSF50447; SSF50447; 1.
PE   2: Evidence at transcript level;
KW   Nucleus; Reference proteome; Repeat; Ribonucleoprotein;
KW   Ribosome biogenesis; RNA-binding; rRNA processing.
FT   CHAIN           1..218
FT                   /note="H/ACA ribonucleoprotein complex subunit 1"
FT                   /id="PRO_0000208556"
FT   REGION          1..57
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          4..49
FT                   /note="RGG-box 1"
FT   REGION          149..218
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          162..214
FT                   /note="RGG-box 2"
SQ   SEQUENCE   218 AA;  22408 MW;  C2686AAF42819BDC CRC64;
     MSFRGRGGFN RGGGGGRGGG GFGGRGGGRG GYGQGGGRGG FGRGGGRGGF NRGGYDQGPP
     ESVVEVGEFM HPCEDDVVCK CITQENRVPY FNAPIYLENK EQIGKVDEIF GQLRDFYFSI
     KLSENMKASS FKKLQKFYID PAKLLPLQRF LPRPPGEKGP PRGGGRGGGR GGGRGRGGGR
     GGGGGFRGGR GGGFGGGGGF RGSRGGGFRG GRGFRGGR