GAR2_MACFA
ID GAR2_MACFA Reviewed; 346 AA.
AC Q95K27;
DT 16-JAN-2004, integrated into UniProtKB/Swiss-Prot.
DT 16-JAN-2004, sequence version 2.
DT 25-MAY-2022, entry version 43.
DE RecName: Full=Golgi associated RAB2 interactor protein 2;
DE Flags: Fragment;
GN Name=GARIN2; Synonyms=FAM71D; ORFNames=QtsA-10859;
OS Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC Cercopithecidae; Cercopithecinae; Macaca.
OX NCBI_TaxID=9541;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Testis;
RX PubMed=12498619; DOI=10.1186/1471-2164-3-36;
RA Osada N., Hida M., Kusuda J., Tanuma R., Hirata M., Suto Y., Hirai M.,
RA Terao K., Sugano S., Hashimoto K.;
RT "Cynomolgus monkey testicular cDNAs for discovery of novel human genes in
RT the human genome sequence.";
RL BMC Genomics 3:36-36(2002).
CC -!- FUNCTION: Seems to play a role in sperm motility.
CC {ECO:0000250|UniProtKB:D3YV92}.
CC -!- SUBUNIT: Interacts with CALM1. {ECO:0000250|UniProtKB:D3YV92}.
CC -!- SUBCELLULAR LOCATION: Cell projection, cilium, flagellum
CC {ECO:0000250|UniProtKB:D3YV92}. Note=In mature sperm, localizes in the
CC midpiece of flagella. {ECO:0000250|UniProtKB:D3YV92}.
CC -!- SIMILARITY: Belongs to the GARIN family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=BAB62945.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};
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DR EMBL; AB070000; BAB62945.1; ALT_INIT; mRNA.
DR AlphaFoldDB; Q95K27; -.
DR STRING; 9541.XP_005561596.1; -.
DR eggNOG; ENOG502S1VC; Eukaryota.
DR Proteomes; UP000233100; Unplaced.
DR GO; GO:0097225; C:sperm midpiece; ISS:UniProtKB.
DR GO; GO:0030317; P:flagellated sperm motility; ISS:UniProtKB.
DR InterPro; IPR022168; DUF3699.
DR Pfam; PF12480; DUF3699; 1.
PE 2: Evidence at transcript level;
KW Cell projection; Cilium; Flagellum; Reference proteome.
FT CHAIN <1..346
FT /note="Golgi associated RAB2 interactor protein 2"
FT /id="PRO_0000089896"
FT REGION 275..346
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 296..318
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT NON_TER 1
SQ SEQUENCE 346 AA; 38766 MW; 6687DC3F85CEB2FF CRC64;
SSTHKIPNVM LLAHLTPGSR KDTEPLFKSL LTSPPAEKLV LTRFLPLQFV TLSVHDAENM
RLKVKLVSGR AYYLQLCTSA CKQDTLFSQW VALISLLNQE KAKVSKVSEV SSLSGITNST
DVTGSTDVMD ITAFTAILTP YMYAGRGPEH VRDSIDFSEF TDITDITDVT DLPENEVPEV
PDIRIVTEVI EVREATEVTD HSDITNCSGV TVVFENNDLI RAKQEEKEKL KNILKPGCLQ
DTKSKSELKE SSKHVTISNI TLTFEGKRYF QTTLTPVESE ANTSKEMENK TSEEKTPDFQ
STALEAEESR SLRTESNTSG NECEERKVKQ KKTKLVEKHV RQPKDF