ID   GAR2_MOUSE              Reviewed;         440 AA.
AC   D3YV92;
DT   25-MAY-2022, integrated into UniProtKB/Swiss-Prot.
DT   20-APR-2010, sequence version 1.
DT   03-AUG-2022, entry version 74.
DE   RecName: Full=Golgi associated RAB2 interactor protein 2 {ECO:0000305};
GN   Name=Garin2; Synonyms=Fam71d {ECO:0000312|MGI:MGI:1918147};
OS   Mus musculus (Mouse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Mus; Mus.
OX   NCBI_TaxID=10090;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=C57BL/6J;
RX   PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA   Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA   Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA   Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA   Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA   Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA   Eichler E.E., Ponting C.P.;
RT   "Lineage-specific biology revealed by a finished genome assembly of the
RT   mouse.";
RL   PLoS Biol. 7:E1000112-E1000112(2009).
RN   [2]
RP   FUNCTION, TISSUE SPECIFICITY, SUBCELLULAR LOCATION, DEVELOPMENTAL STAGE,
RP   AND INTERACTION WITH CALM1.
RX   PubMed=29025071; DOI=10.1093/humrep/dex290;
RA   Ma Q., Li Y., Luo M., Guo H., Lin S., Chen J., Du Y., Jiang Z., Gui Y.;
RT   "The expression characteristics of FAM71D and its association with sperm
RT   motility.";
RL   Hum. Reprod. 32:2178-2187(2017).
CC   -!- FUNCTION: Seems to play a role in sperm motility.
CC       {ECO:0000269|PubMed:29025071}.
CC   -!- SUBUNIT: Interacts with CALM1. {ECO:0000269|PubMed:29025071}.
CC   -!- SUBCELLULAR LOCATION: Cell projection, cilium, flagellum
CC       {ECO:0000269|PubMed:29025071}. Note=In mature sperm, localizes in the
CC       midpiece of flagella. {ECO:0000269|PubMed:29025071}.
CC   -!- TISSUE SPECIFICITY: Expressed in testis (at protein level).
CC       {ECO:0000269|PubMed:29025071}.
CC   -!- DEVELOPMENTAL STAGE: Expression increases from 3 weeks to 6 months
CC       (PubMed:29025071). In mouse testis, mainly localized in the cytoplasm
CC       of round spermatids and elongated spermatids. In the cap phase, remains
CC       close to the acrosomes but begins to migrate to other regions around
CC       the nuclei. As spermiogenesis progresses, further separates from the
CC       acrosomes. In the acrosome phase, while the acrosomes formed hook-like
CC       structures and move toward one end of the nuclei, GARIN2 moveS to the
CC       opposite end. In the maturation phase, moves to the end opposite to the
CC       acrosomes and, at the end of spermiogenesis, is removed to the residue
CC       body together with most of the other cytosolic components. Finally, in
CC       caudal sperm, is retained in sperm flagella. In mature sperm, GARIN2
CC       localizes in the midpiece of flagella (PubMed:29025071).
CC       {ECO:0000269|PubMed:29025071}.
CC   -!- SIMILARITY: Belongs to the GARIN family. {ECO:0000305}.
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DR   RefSeq; NP_083345.1; NM_029069.1.
DR   RefSeq; XP_006516290.1; XM_006516227.2.
DR   RefSeq; XP_011242474.1; XM_011244172.1.
DR   RefSeq; XP_011242475.1; XM_011244173.1.
DR   RefSeq; XP_017170684.1; XM_017315195.1.
DR   RefSeq; XP_017170685.1; XM_017315196.1.
DR   AlphaFoldDB; D3YV92; -.
DR   STRING; 10090.ENSMUSP00000077119; -.
DR   iPTMnet; D3YV92; -.
DR   PhosphoSitePlus; D3YV92; -.
DR   PaxDb; D3YV92; -.
DR   PRIDE; D3YV92; -.
DR   ProteomicsDB; 332720; -.
DR   Antibodypedia; 68; 41 antibodies from 12 providers.
DR   DNASU; 70897; -.
DR   Ensembl; ENSMUST00000077968; ENSMUSP00000077119; ENSMUSG00000056987.
DR   GeneID; 70897; -.
DR   UCSC; uc007nzf.2; mouse.
DR   CTD; 161142; -.
DR   MGI; MGI:1918147; Fam71d.
DR   VEuPathDB; HostDB:ENSMUSG00000056987; -.
DR   eggNOG; ENOG502S1VC; Eukaryota.
DR   GeneTree; ENSGT00940000161537; -.
DR   HOGENOM; CLU_055234_0_0_1; -.
DR   InParanoid; D3YV92; -.
DR   OMA; STMRINK; -.
DR   OrthoDB; 1402381at2759; -.
DR   PhylomeDB; D3YV92; -.
DR   TreeFam; TF336050; -.
DR   BioGRID-ORCS; 70897; 2 hits in 71 CRISPR screens.
DR   Proteomes; UP000000589; Chromosome 12.
DR   RNAct; D3YV92; protein.
DR   Bgee; ENSMUSG00000056987; Expressed in spermatid and 43 other tissues.
DR   ExpressionAtlas; D3YV92; baseline and differential.
DR   GO; GO:0097225; C:sperm midpiece; IDA:UniProtKB.
DR   GO; GO:0030317; P:flagellated sperm motility; IDA:UniProtKB.
DR   InterPro; IPR022168; DUF3699.
DR   Pfam; PF12480; DUF3699; 1.
PE   1: Evidence at protein level;
KW   Cell projection; Cilium; Flagellum; Reference proteome.
FT   CHAIN           1..440
FT                   /note="Golgi associated RAB2 interactor protein 2"
FT                   /id="PRO_0000455124"
SQ   SEQUENCE   440 AA;  50108 MW;  7C861A11F6699D1A CRC64;
     MMKKNRNKKA MNKQEALFIP HYYRLGHLKN ILDGGEYAPY VSPPILESNF IQVNRRGESI
     YLHNRANWVT VGICSSNPIF KTPNMMLLAH LTPEARKEPE PLFKTLLKSS SSGTLVLTRF
     IPLQFVTLSV HSAKNMRLKV KLINGRSYYL QLCAPVYKQD IIFSQWVDLI PLLNQEKIKN
     TKVSEVSSLS ELTNSTDIAG SMDITDITAF RELRPRHPKT HRYPCNIMES ADFSEYTDVT
     DVTDVTDVTD MLDNGITDVQ DIKIVTEVTE VTEVTEVTEV SEVSDVKMAT NISGVKIVFE
     NDDIIKTKQE EKEYTLKHRS LQDTKTKSDY QDSPNPVTMS NIALALQDEG CFQTTQTPVK
     SKEDIYKEIC DETSEENMIR LQNIHLKATE SRSTRTDSDI SDGELKLGRY LHKQCSSREQ
     SFIHSLGSLP RGFVFLHLLL