GAR3_MOUSE
ID GAR3_MOUSE Reviewed; 665 AA.
AC Q5STT6;
DT 01-MAY-2007, integrated into UniProtKB/Swiss-Prot.
DT 18-SEP-2013, sequence version 3.
DT 03-AUG-2022, entry version 102.
DE RecName: Full=Golgi associated RAB2B interactor protein 3;
DE AltName: Full=Protein FAM71B;
GN Name=Garin3; Synonyms=Fam71b;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J;
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
RN [2]
RP INTERACTION WITH RAB2B, AND SUBCELLULAR LOCATION.
RC STRAIN=BALB/cJ;
RX PubMed=18256213; DOI=10.1074/mcp.m700569-mcp200;
RA Fukuda M., Kanno E., Ishibashi K., Itoh T.;
RT "Large scale screening for novel rab effectors reveals unexpected broad Rab
RT binding specificity.";
RL Mol. Cell. Proteomics 7:1031-1042(2008).
RN [3]
RP TISSUE SPECIFICITY.
RX PubMed=25609838; DOI=10.1095/biolreprod.114.126250;
RA Petit F.G., Kervarrec C., Jamin S.P., Smagulova F., Hao C., Becker E.,
RA Jegou B., Chalmel F., Primig M.;
RT "Combining RNA and protein profiling data with network interactions
RT identifies genes associated with spermatogenesis in mouse and human.";
RL Biol. Reprod. 92:71-71(2015).
CC -!- FUNCTION: May be involved in RNA biogenesis.
CC {ECO:0000250|UniProtKB:Q8TC56}.
CC -!- SUBUNIT: Interacts (via N-terminus) with RAB2B (in GTP-bound form)
CC (PubMed:18256213). Interacts with FRG1. {ECO:0000250,
CC ECO:0000269|PubMed:18256213}.
CC -!- SUBCELLULAR LOCATION: Golgi apparatus {ECO:0000305|PubMed:18256213}.
CC Nucleus, Cajal body {ECO:0000250|UniProtKB:Q8TC56}.
CC -!- TISSUE SPECIFICITY: Expressed in adult spermatocytes and spermatids.
CC {ECO:0000269|PubMed:25609838}.
CC -!- SIMILARITY: Belongs to the GARIN family. {ECO:0000305}.
CC -!- CAUTION: It is uncertain whether Met-1 or Met-8 is the initiator.
CC {ECO:0000305}.
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DR EMBL; AL662806; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR CCDS; CCDS24576.1; -.
DR RefSeq; NP_001013805.1; NM_001013783.2.
DR AlphaFoldDB; Q5STT6; -.
DR STRING; 10090.ENSMUSP00000055079; -.
DR iPTMnet; Q5STT6; -.
DR PhosphoSitePlus; Q5STT6; -.
DR PaxDb; Q5STT6; -.
DR PRIDE; Q5STT6; -.
DR ProteomicsDB; 275581; -.
DR Antibodypedia; 28391; 45 antibodies from 11 providers.
DR DNASU; 432552; -.
DR Ensembl; ENSMUST00000063166; ENSMUSP00000055079; ENSMUSG00000020401.
DR GeneID; 432552; -.
DR KEGG; mmu:432552; -.
DR UCSC; uc007ioj.2; mouse.
DR CTD; 153745; -.
DR MGI; MGI:3650836; Fam71b.
DR VEuPathDB; HostDB:ENSMUSG00000020401; -.
DR eggNOG; ENOG502S0XQ; Eukaryota.
DR GeneTree; ENSGT00940000162063; -.
DR HOGENOM; CLU_035424_0_0_1; -.
DR InParanoid; Q5STT6; -.
DR OMA; TREDLFC; -.
DR OrthoDB; 982161at2759; -.
DR PhylomeDB; Q5STT6; -.
DR TreeFam; TF336050; -.
DR BioGRID-ORCS; 432552; 3 hits in 71 CRISPR screens.
DR ChiTaRS; Fam71b; mouse.
DR PRO; PR:Q5STT6; -.
DR Proteomes; UP000000589; Chromosome 11.
DR RNAct; Q5STT6; protein.
DR Bgee; ENSMUSG00000020401; Expressed in seminiferous tubule of testis and 15 other tissues.
DR Genevisible; Q5STT6; MM.
DR GO; GO:0015030; C:Cajal body; IEA:UniProtKB-SubCell.
DR GO; GO:0005794; C:Golgi apparatus; IDA:UniProtKB.
DR InterPro; IPR022168; DUF3699.
DR Pfam; PF12480; DUF3699; 1.
PE 1: Evidence at protein level;
KW Golgi apparatus; Nucleus; Phosphoprotein; Reference proteome.
FT CHAIN 1..665
FT /note="Golgi associated RAB2B interactor protein 3"
FT /id="PRO_0000285644"
FT REGION 211..240
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 272..296
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 480..590
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOTIF 515..531
FT /note="Bipartite nuclear localization signal"
FT /evidence="ECO:0000255"
FT COMPBIAS 211..232
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 497..512
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 513..529
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 530..554
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 555..579
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 652
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q66H38"
SQ SEQUENCE 665 AA; 68885 MW; 02CE329C22467ED5 CRC64;
MPGMKRTMSS ECLLPYYTAH SYRSMGVFNT SMGNLQRQLY KGGEYDIFKY APMFESDFIQ
ISKRGEVIDV HNRVRMVTVC IASTSPVLPL PDVMLLARPA KVCEEHARRA RFIKGKGCKP
SKTLELTRLL PLKFVKISVH DHEKQQLRLK LATGRTFYLQ LCPSSDARED LFCYWEKLVY
LLRPPMTNCI SNSTLPTGET SVDTKSTLVS EIRGEGDQNS RPQSSPTVSE ATSAAFAGGE
RTQPAAAAAV TPVSAKARAA GTAGAAAGTA GAAAGTAGPA AGPAAGTAGP AAGTAGAAAG
TAGAAAGTAG ATAGTAGATA GMAGATAGTA AETAGTAAET AGAARAAGGP MAAAVAAPSA
GMTKAETATS PTSGVISLAA TTTKPPGSGQ VAAAMIGSAA KDQVGGESSK AMALAANITL
ENVDVALAGA ANSISESPPA GGDASGSPDT GLNVAFAGSI KTKSPAEDKP EAPLVSTLQS
EGYMCERDGS QKVSQTSSEA KEKRERREKD RTSSRKSSHH RRTGMSRHSS KDKSRKTSSY
RSVSGKTRED KGKGHGRLRG KRHSSSHKSE SRTGHKTRKN RSPAGLGSVS KRATKITSFF
RSFLVRPTPK AGDTSCDRGG VDIVTKLVEK KQDIEAVMEK SKDSEFKDTV ISETMEKIIL
ETKSI
