ID   GAR3_RAT                Reviewed;         647 AA.
AC   Q66H38;
DT   01-MAY-2007, integrated into UniProtKB/Swiss-Prot.
DT   11-OCT-2004, sequence version 1.
DT   03-AUG-2022, entry version 85.
DE   RecName: Full=Golgi associated RAB2B interactor protein 3;
DE   AltName: Full=Protein FAM71B;
GN   Name=Garin3; Synonyms=Fam71b;
OS   Rattus norvegicus (Rat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Rattus.
OX   NCBI_TaxID=10116;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Testis;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
RN   [2]
RP   PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-378; SER-634 AND SER-636, AND
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX   PubMed=22673903; DOI=10.1038/ncomms1871;
RA   Lundby A., Secher A., Lage K., Nordsborg N.B., Dmytriyev A., Lundby C.,
RA   Olsen J.V.;
RT   "Quantitative maps of protein phosphorylation sites across 14 different rat
RT   organs and tissues.";
RL   Nat. Commun. 3:876-876(2012).
CC   -!- FUNCTION: May be involved in RNA biogenesis.
CC       {ECO:0000250|UniProtKB:Q8TC56}.
CC   -!- SUBUNIT: Interacts (via N-terminus) with RAB2B (in GTP-bound form) (By
CC       similarity). Interacts with FRG1 (By similarity).
CC       {ECO:0000250|UniProtKB:Q5STT6, ECO:0000250|UniProtKB:Q8TC56}.
CC   -!- SUBCELLULAR LOCATION: Golgi apparatus {ECO:0000250|UniProtKB:Q5STT6}.
CC       Nucleus, Cajal body {ECO:0000250|UniProtKB:Q8TC56}.
CC   -!- SIMILARITY: Belongs to the GARIN family. {ECO:0000305}.
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DR   EMBL; BC082044; AAH82044.1; -; mRNA.
DR   RefSeq; NP_001020202.2; NM_001025031.1.
DR   AlphaFoldDB; Q66H38; -.
DR   STRING; 10116.ENSRNOP00000030691; -.
DR   iPTMnet; Q66H38; -.
DR   PhosphoSitePlus; Q66H38; -.
DR   PaxDb; Q66H38; -.
DR   PRIDE; Q66H38; -.
DR   GeneID; 497888; -.
DR   KEGG; rno:497888; -.
DR   UCSC; RGD:1563555; rat.
DR   CTD; 153745; -.
DR   RGD; 1563555; Fam71b.
DR   eggNOG; ENOG502S0XQ; Eukaryota.
DR   HOGENOM; CLU_035424_0_0_1; -.
DR   InParanoid; Q66H38; -.
DR   OrthoDB; 982161at2759; -.
DR   PhylomeDB; Q66H38; -.
DR   PRO; PR:Q66H38; -.
DR   Proteomes; UP000002494; Unplaced.
DR   GO; GO:0015030; C:Cajal body; IEA:UniProtKB-SubCell.
DR   GO; GO:0005794; C:Golgi apparatus; ISS:UniProtKB.
DR   InterPro; IPR022168; DUF3699.
DR   InterPro; IPR000048; IQ_motif_EF-hand-BS.
DR   Pfam; PF12480; DUF3699; 1.
PE   1: Evidence at protein level;
KW   Golgi apparatus; Nucleus; Phosphoprotein; Reference proteome.
FT   CHAIN           1..647
FT                   /note="Golgi associated RAB2B interactor protein 3"
FT                   /id="PRO_0000285645"
FT   REGION          188..220
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          267..296
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          361..384
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          465..573
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOTIF           494..511
FT                   /note="Bipartite nuclear localization signal"
FT                   /evidence="ECO:0000255"
FT   COMPBIAS        188..202
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        203..217
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        361..380
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        475..494
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        505..560
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOD_RES         378
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0007744|PubMed:22673903"
FT   MOD_RES         634
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0007744|PubMed:22673903"
FT   MOD_RES         636
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0007744|PubMed:22673903"
SQ   SEQUENCE   647 AA;  68071 MW;  B04129C913FA9B06 CRC64;
     MSSECLLPYY TAHSYRSMGV FNTSMGNLQR QLYKGGEYDI FKYAPMFESD FIQISKKGEV
     IDVHNRVRMV TVCIASTSPV LPLPDVMLLA RPAKVCEEHA RRARFIKGRG YKPSKTLELT
     RLLPLKFVKI SIHDHEKQQL RLKLATGRTF YLQLCPSSDA REDLFCYWEK LVYLLRPPVN
     SCISNPSIPT ADTSTETKST LVSEIHGEGD RDSKFQTSQD VSEATSAAFA GGERTQPNIA
     AILTTGLAKA RAAGAAAGTG AAGTAGTAGA AGATGAAGAT GAAGSARAAG GAGSARAAGA
     TGSARAAGAT GSARAAGATG SARAAGGNTA AAVMTPLAGL ARAGTPTSPV SGVISIAATT
     SKSPGSGQVA TGLTGTASKD QERSESSKAM AVVANITTES VDVVLAGAAS FTSESPSAEG
     DAYGSPDTGL NVAFAGSITT KGPAEDKPEA PLVSTLQSEG YMCERDGSQK VSHTSSETQK
     EKRERRESDR KGSRKSSHHQ RTGASRHSSS KDKGRKTSSY RSVSGHGKTR EDKKEKGRGS
     LRDQRHSSSY RSESRTGHKS RKNRPAASGG FVSKRATKIR SFFRAFLVRP TLKTENTSGE
     RGGVDIVTKL VEKQDIETTV EKSKDLEFSD TMASESMEKI ILETKPI